Potentiation of the 5-hydroxytryptamine-induced increases in myocardial contractility in Mercenaria mercenaria ventricle by forskolin

Giulio Franco Paciotti, William Joseph Higgins

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

1. Forskolin (10-5 M), an activator of adenylate cyclase in many mammalian cell types, potentiated the positive inotropic effects of 5-hydroxytryptamine (5-HT) on the bivalve, Mercenaria mercenaria, myocardium. 2. Forskolin (10-5 M) also significantly increased intracellular cyclic AMP concentrations when compared to 5-HT controls. 3. Ro 20-1724 (10-5 M), a putative inhibitor of cyclic AMP phosphodiesterase, had no effect on myocardial contractility or cyclic AMP concentration. 4. A positive correlation between intracellular cyclic AMP concentration and the efficacy of 5-HT was obtained.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume80
Issue number2
DOIs
StatePublished - Jan 1 1985

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Mercenaria
Colforsin
Cyclic AMP
Serotonin
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
Bivalvia
Phosphoric Diester Hydrolases
Adenylyl Cyclases
Myocardium

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Potentiation of the 5-hydroxytryptamine-induced increases in myocardial contractility in Mercenaria mercenaria ventricle by forskolin. / Paciotti, Giulio Franco; Higgins, William Joseph.

In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 80, No. 2, 01.01.1985, p. 325-329.

Research output: Contribution to journalArticle

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