1. Forskolin (10-5 M), an activator of adenylate cyclase in many mammalian cell types, potentiated the positive inotropic effects of 5-hydroxytryptamine (5-HT) on the bivalve, Mercenaria mercenaria, myocardium. 2. Forskolin (10-5 M) also significantly increased intracellular cyclic AMP concentrations when compared to 5-HT controls. 3. Ro 20-1724 (10-5 M), a putative inhibitor of cyclic AMP phosphodiesterase, had no effect on myocardial contractility or cyclic AMP concentration. 4. A positive correlation between intracellular cyclic AMP concentration and the efficacy of 5-HT was obtained.
|Original language||English (US)|
|Number of pages||5|
|Journal||Comparative Biochemistry and Physiology. Part C, Comparative|
|State||Published - 1985|
ASJC Scopus subject areas