Potentiation of the 5-hydroxytryptamine-induced increases in myocardial contractility in Mercenaria mercenaria ventricle by forskolin

Giulio Franco Paciotti, William J. Higgins

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

1. Forskolin (10-5 M), an activator of adenylate cyclase in many mammalian cell types, potentiated the positive inotropic effects of 5-hydroxytryptamine (5-HT) on the bivalve, Mercenaria mercenaria, myocardium. 2. Forskolin (10-5 M) also significantly increased intracellular cyclic AMP concentrations when compared to 5-HT controls. 3. Ro 20-1724 (10-5 M), a putative inhibitor of cyclic AMP phosphodiesterase, had no effect on myocardial contractility or cyclic AMP concentration. 4. A positive correlation between intracellular cyclic AMP concentration and the efficacy of 5-HT was obtained.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume80
Issue number2
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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