Pre-diabetes, Diabetes, Hyperglycemia, and Stroke: Bittersweet Therapeutic Opportunities

Research output: Contribution to journalReview articlepeer-review


Purposeof Review: Diabetes mellitus (DM) causes systemic vascular complications. Chronic hyperglycemia is a hallmark of DM and appears to be at least partially responsible for the vascular complications. In addition, hyperglycemia during acute tissue injury has been postulated to augment the injury. This review addresses the potential therapeutic benefits related to ischemic stroke from lowering hyperglycemia in two settings, in chronic hyperglycemia and during acute ischemic stroke. Recent Findings: A recent efficacy trial to lower hyperglycemia during acute ischemic stroke showed no significant benefit overall as well as in patient subgroups. This finding helps to establish good clinical practice protocols for patients with acute ischemic stroke and hyperglycemia. Summary: Hyperglycemia appears to be a key mediator of the systemic vascular complications of DM. Despite current lack of evidence that lowering hyperglycemia during acute ischemic stroke improves functional outcome, unanswered questions remain in specific acute ischemic stroke settings that warrant additional research.

Original languageEnglish (US)
Pages (from-to)781-787
Number of pages7
JournalCurrent neurology and neuroscience reports
Issue number11
StatePublished - Nov 2022


  • Diabetes Mellitus
  • Hyperglycemia
  • Hypoglycemia
  • Ischemic Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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