Preconception ovarian reserve and placenta-mediated pregnancy complications among infertile women

for the NIH/NICHD Reproductive Medicine Network

Research output: Contribution to journalArticlepeer-review

Abstract

Research question: Are preconception ovarian reserve markers, such as Anti-Mullerian hormone and antral follicle count, associated with preeclampsia and placenta mediated pregnancy complications among women with unexplained infertility who conceive with superovulation? Design: This is a secondary analysis of women with unexplained infertility who had a singleton live birth after enrollment in the Analysis of Multiple Intrauterine Gestations after Ovarian Stimulation (AMIGOS) trial that randomized couples to superovulation with letrozole, clomiphene, or gonadotropins with insemination for up to 4 cycles. Results: Compared to controls (N = 156), women who developed preeclampsia (N = 17) had lower Anti-Mullerian hormone levels (2.24 ± 1.20 vs. 2.89 ± 2.32, p = 0.07) and lower antral follicle count (18 ± 7.67 vs. 21 ± 11.43, p = 0.16); though these differences were not statistically significant. There was no relationship between Anti-Mullerian hormone (OR: 1.00, 95% CI: 0.76–1.25) or antral follicle count (OR: 0.98, 95% CI 0.93–1.04) with preeclampsia and between Anti-Mullerian hormone (OR: 1.00, 95% CI: 0.83–1.17) and antral follicle count (OR: 1.00, 95% CI: 0.97–1.04) with placenta medicated pregnancy complications after adjusting for age, BMI and race. Conclusions: Preconception ovarian reserve markers are not associated with preeclampsia and placenta mediated pregnancy complications among women with unexplained infertility who conceive with superovulation with insemination.

Original languageEnglish (US)
Pages (from-to)193-196
Number of pages4
JournalPregnancy Hypertension
Volume27
DOIs
StatePublished - Mar 2022
Externally publishedYes

Keywords

  • AMH
  • Antral follicle count
  • Infertility
  • Ovarian reserve
  • Placenta complications
  • Preeclampsia

ASJC Scopus subject areas

  • Internal Medicine
  • Obstetrics and Gynecology

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