Abstract
Background. The objective of this study was to increase the ability to predict renal transplant patients (RTPs) who are most likely to be non-adherent to their immunosuppressant therapy (IST). Methods. One hundred and fifty-eight RTPs completed questionnaires assessing Theory of Planned Behaviour (TPB) variables (attitudes, subjective norms and perceived behavioural control) relevant to intentions to adhere to their IST, with the addition of a general measure of past adherence to medical advice. In the full sample, intentions to adhere to IST was the outcome variable. In a subsample of 70 RTPs, the primary outcome was IST adherence. Results. TPB variables (attitudes, β = 0.32, P< 0.01; perceived behavioural control, β 0.37, P <0.01; but not subjective norms, β 0.001, ns) explained 41% of the variance in intentions to adhere to IST (P < 0.001). Past behaviour predicted perceived behavioural control (β = 0.67, P < 0.001). Subsample analyses explained 33% (P < 0.001) of the variance in adherence, with intentions and past behaviour being the primary factors (P < 0.05). Conclusions. RTPs particularly at risk may be those who have a history of non-adherence to medical advice, especially when they have negative attitudes about IST adherence and feel they have little control over their medication-taking behaviour. Interventions to improve attitudes about IST adherence and control of adherence behaviour are needed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2339-2348 |
| Number of pages | 10 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 22 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2007 |
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Keywords
- Adherence
- Immunosuppressant medications
- Renal transplant recipients
ASJC Scopus subject areas
- Nephrology
- Transplantation
Cite this
Predicting adherence to immunosuppressant therapy : A prospective analysis of the theory of planned behaviour. / Chisholm, Marie A.; Williamson, Gail M.; Lance, Charles E.; Mulloy, Laura L.
In: Nephrology Dialysis Transplantation, Vol. 22, No. 8, 01.08.2007, p. 2339-2348.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predicting adherence to immunosuppressant therapy
T2 - A prospective analysis of the theory of planned behaviour
AU - Chisholm, Marie A.
AU - Williamson, Gail M.
AU - Lance, Charles E.
AU - Mulloy, Laura L
PY - 2007/8/1
Y1 - 2007/8/1
N2 - Background. The objective of this study was to increase the ability to predict renal transplant patients (RTPs) who are most likely to be non-adherent to their immunosuppressant therapy (IST). Methods. One hundred and fifty-eight RTPs completed questionnaires assessing Theory of Planned Behaviour (TPB) variables (attitudes, subjective norms and perceived behavioural control) relevant to intentions to adhere to their IST, with the addition of a general measure of past adherence to medical advice. In the full sample, intentions to adhere to IST was the outcome variable. In a subsample of 70 RTPs, the primary outcome was IST adherence. Results. TPB variables (attitudes, β = 0.32, P< 0.01; perceived behavioural control, β 0.37, P <0.01; but not subjective norms, β 0.001, ns) explained 41% of the variance in intentions to adhere to IST (P < 0.001). Past behaviour predicted perceived behavioural control (β = 0.67, P < 0.001). Subsample analyses explained 33% (P < 0.001) of the variance in adherence, with intentions and past behaviour being the primary factors (P < 0.05). Conclusions. RTPs particularly at risk may be those who have a history of non-adherence to medical advice, especially when they have negative attitudes about IST adherence and feel they have little control over their medication-taking behaviour. Interventions to improve attitudes about IST adherence and control of adherence behaviour are needed.
AB - Background. The objective of this study was to increase the ability to predict renal transplant patients (RTPs) who are most likely to be non-adherent to their immunosuppressant therapy (IST). Methods. One hundred and fifty-eight RTPs completed questionnaires assessing Theory of Planned Behaviour (TPB) variables (attitudes, subjective norms and perceived behavioural control) relevant to intentions to adhere to their IST, with the addition of a general measure of past adherence to medical advice. In the full sample, intentions to adhere to IST was the outcome variable. In a subsample of 70 RTPs, the primary outcome was IST adherence. Results. TPB variables (attitudes, β = 0.32, P< 0.01; perceived behavioural control, β 0.37, P <0.01; but not subjective norms, β 0.001, ns) explained 41% of the variance in intentions to adhere to IST (P < 0.001). Past behaviour predicted perceived behavioural control (β = 0.67, P < 0.001). Subsample analyses explained 33% (P < 0.001) of the variance in adherence, with intentions and past behaviour being the primary factors (P < 0.05). Conclusions. RTPs particularly at risk may be those who have a history of non-adherence to medical advice, especially when they have negative attitudes about IST adherence and feel they have little control over their medication-taking behaviour. Interventions to improve attitudes about IST adherence and control of adherence behaviour are needed.
KW - Adherence
KW - Immunosuppressant medications
KW - Renal transplant recipients
UR - http://www.scopus.com/inward/record.url?scp=34547830304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547830304&partnerID=8YFLogxK
U2 - 10.1093/ndt/gfm149
DO - 10.1093/ndt/gfm149
M3 - Article
C2 - 17442741
AN - SCOPUS:34547830304
VL - 22
SP - 2339
EP - 2348
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
SN - 0931-0509
IS - 8
ER -