TY - JOUR
T1 - Predicting adherence to immunosuppressant therapy
T2 - A prospective analysis of the theory of planned behaviour
AU - Chisholm, Marie A.
AU - Williamson, Gail M.
AU - Lance, Charles E.
AU - Mulloy, Laura L.
N1 - Funding Information:
Acknowledgements. This research was partially funded by the Carlos and Marguerite Mason Trust Fund (M. A. C., principal investigator). Participation in this research was facilitated by a grant from the National Institute on Aging (AG15321, G. M. W., principal investigator; C. E. L., co-investigator) and by a fellowship from the Institute for Behavioral Research at the University of Georgia (G. M. W.). All of the authors listed had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analyses.
PY - 2007/8
Y1 - 2007/8
N2 - Background. The objective of this study was to increase the ability to predict renal transplant patients (RTPs) who are most likely to be non-adherent to their immunosuppressant therapy (IST). Methods. One hundred and fifty-eight RTPs completed questionnaires assessing Theory of Planned Behaviour (TPB) variables (attitudes, subjective norms and perceived behavioural control) relevant to intentions to adhere to their IST, with the addition of a general measure of past adherence to medical advice. In the full sample, intentions to adhere to IST was the outcome variable. In a subsample of 70 RTPs, the primary outcome was IST adherence. Results. TPB variables (attitudes, β = 0.32, P< 0.01; perceived behavioural control, β 0.37, P <0.01; but not subjective norms, β 0.001, ns) explained 41% of the variance in intentions to adhere to IST (P < 0.001). Past behaviour predicted perceived behavioural control (β = 0.67, P < 0.001). Subsample analyses explained 33% (P < 0.001) of the variance in adherence, with intentions and past behaviour being the primary factors (P < 0.05). Conclusions. RTPs particularly at risk may be those who have a history of non-adherence to medical advice, especially when they have negative attitudes about IST adherence and feel they have little control over their medication-taking behaviour. Interventions to improve attitudes about IST adherence and control of adherence behaviour are needed.
AB - Background. The objective of this study was to increase the ability to predict renal transplant patients (RTPs) who are most likely to be non-adherent to their immunosuppressant therapy (IST). Methods. One hundred and fifty-eight RTPs completed questionnaires assessing Theory of Planned Behaviour (TPB) variables (attitudes, subjective norms and perceived behavioural control) relevant to intentions to adhere to their IST, with the addition of a general measure of past adherence to medical advice. In the full sample, intentions to adhere to IST was the outcome variable. In a subsample of 70 RTPs, the primary outcome was IST adherence. Results. TPB variables (attitudes, β = 0.32, P< 0.01; perceived behavioural control, β 0.37, P <0.01; but not subjective norms, β 0.001, ns) explained 41% of the variance in intentions to adhere to IST (P < 0.001). Past behaviour predicted perceived behavioural control (β = 0.67, P < 0.001). Subsample analyses explained 33% (P < 0.001) of the variance in adherence, with intentions and past behaviour being the primary factors (P < 0.05). Conclusions. RTPs particularly at risk may be those who have a history of non-adherence to medical advice, especially when they have negative attitudes about IST adherence and feel they have little control over their medication-taking behaviour. Interventions to improve attitudes about IST adherence and control of adherence behaviour are needed.
KW - Adherence
KW - Immunosuppressant medications
KW - Renal transplant recipients
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U2 - 10.1093/ndt/gfm149
DO - 10.1093/ndt/gfm149
M3 - Article
C2 - 17442741
AN - SCOPUS:34547830304
VL - 22
SP - 2339
EP - 2348
JO - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
JF - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
SN - 0931-0509
IS - 8
ER -