Predicting bone scan positivity in non-metastatic castration-resistant prostate cancer

D. M. Moreira, L. E. Howard, K. N. Sourbeer, H. S. Amarasekara, L. C. Chow, D. C. Cockrell, B. T. Hanyok, C. L. Pratson, W. J. Aronson, C. J. Kane, M. K. Terris, C. L. Amling, M. R. Cooperberg, A. Liede, S. J. Freedland

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background:To evaluate PSA levels and kinetic cutoffs to predict positive bone scans for men with non-metastatic castration-resistant prostate cancer (CRPC) from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort.Methods:Retrospective analysis of 531 bone scans of 312 clinically CRPC patients with no known metastases at baseline treated with a variety of primary treatment types in the SEARCH database. The association of patients' demographics, pathological features, PSA levels and kinetics with risk of a positive scan was tested using generalized estimating equations.Results:A total of 149 (28%) scans were positive. Positive scans were associated with younger age (odds ratio (OR)=0.98; P=0.014), higher Gleason scores (relative to Gleason 2-6, Gleason 3+4: OR=2.03, P=0.035; Gleason 4+3 and 8-10: OR=1.76, P=0.059), higher prescan PSA (OR=2.11; P<0.001), shorter prescan PSA doubling time (PSADT; OR=0.53; P<0.001), higher PSA velocity (OR=1.74; P<0.001) and more remote scan year (OR=0.92; P=0.004). Scan positivity was 6, 14, 29 and 57% for men with PSA<5, 5-14.9, 15-49.9 and ≥50 ng ml -1, respectively (P-trend <0.001). Men with PSADT ≥15, 9-14.9, 3-8.9 and <3 months had a scan positivity of 11, 22, 34 and 47%, correspondingly (P-trend <0.001). Tables were constructed using PSA and PSADT to predict the likelihood of a positive bone scan.Conclusions:PSA levels and kinetics were associated with positive bone scans. We developed tables to predict the risk of positive bone scans by PSA and PSADT. Combining PSA levels and kinetics may help select patients with CRPC for bone scans.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalProstate Cancer and Prostatic Diseases
Volume18
Issue number4
DOIs
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

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    Moreira, D. M., Howard, L. E., Sourbeer, K. N., Amarasekara, H. S., Chow, L. C., Cockrell, D. C., Hanyok, B. T., Pratson, C. L., Aronson, W. J., Kane, C. J., Terris, M. K., Amling, C. L., Cooperberg, M. R., Liede, A., & Freedland, S. J. (2015). Predicting bone scan positivity in non-metastatic castration-resistant prostate cancer. Prostate Cancer and Prostatic Diseases, 18(4), 333-337. https://doi.org/10.1038/pcan.2015.25