TY - JOUR
T1 - Prediction of antidepressant response in both 2.25 × threshold RUL and fixed high dose RUL ECT
AU - Kimball, James N.
AU - Rosenquist, Peter B.
AU - Dunn, Aaron
AU - McCall, Vaughn
N1 - Funding Information:
Seizure duration was the earliest marker of treatment adequacy in ECT. By the 1970s, the field embraced seizure durations > 25 s as an indicator of treatment adequacy. This position was supported by the work of Cronholm and Ottosson in a 1960 paper which examined the effect of lidocaine pre-treatment in ECT. This study showed that “where seizures were shortened by lidocaine the depression-relieving effect of ECT is decreased.” The authors also inferred that since “reduction of seizure activity decreases the therapeutic efficiency of ECT…”, we “argue in favor of seizure activity as the sole, or at least a dominant factor” in efficacy ( Cronholm and Ottosson, 1960 ).
PY - 2009/1
Y1 - 2009/1
N2 - Some forms of electroconvulsive therapy (ECT) can result in generalized seizures that lack efficacy, therefore physiological markers of treatment adequacy would be helpful. EEG measures of seizure quality, such as EEG regularity and post-ictal suppression, have largely supplanted seizure duration as a marker for seizure adequacy, yet no predictive algorithm has gained wide clinical acceptance. Electrographic seizure durations of less than 25 s still prompt re-stimulation in many settings. We re-examined the utility of EEG seizure duration and other measures of EEG seizure as predictors of antidepressant response to right unilateral (RUL) ECT. Methods: Seventy-two adult patients with major depression were randomized to either titrated RUL ECT at 2.25 times initial seizure threshold or RUL ECT at a fixed dose of 403 mC. Intent-to-treat responder status (defined by 60% reduction in HRSD scores and final score of 12 or less after the last RUL ECT session) was identified as the dependent variable in a nominal logistic regression model including EEG seizure quality candidate variables, controlled for age and gender. Results: A model including EEG seizure duration, EEG regularity, post-ictal suppression, age and gender and randomization status was significantly predictive of intent-to-treat responder status at treatment 2 (R2 = .21 p < .003; N = 66) and treatment 4 (R2 = .27 p < .0004; N = 67). The model remained significant at these time points even when randomization status (titrated moderately suprathreshold vs. high fixed dosage) was removed (Treatment 2: R2 = .18 p < .007; Treatment 4: R2 = .23 p < .0007). Conclusion: EEG markers of seizure adequacy, including EEG seizure duration, are modestly predictive of antidepressant response for both titrated moderately suprathreshold and high fixed dosage RUL ECT.
AB - Some forms of electroconvulsive therapy (ECT) can result in generalized seizures that lack efficacy, therefore physiological markers of treatment adequacy would be helpful. EEG measures of seizure quality, such as EEG regularity and post-ictal suppression, have largely supplanted seizure duration as a marker for seizure adequacy, yet no predictive algorithm has gained wide clinical acceptance. Electrographic seizure durations of less than 25 s still prompt re-stimulation in many settings. We re-examined the utility of EEG seizure duration and other measures of EEG seizure as predictors of antidepressant response to right unilateral (RUL) ECT. Methods: Seventy-two adult patients with major depression were randomized to either titrated RUL ECT at 2.25 times initial seizure threshold or RUL ECT at a fixed dose of 403 mC. Intent-to-treat responder status (defined by 60% reduction in HRSD scores and final score of 12 or less after the last RUL ECT session) was identified as the dependent variable in a nominal logistic regression model including EEG seizure quality candidate variables, controlled for age and gender. Results: A model including EEG seizure duration, EEG regularity, post-ictal suppression, age and gender and randomization status was significantly predictive of intent-to-treat responder status at treatment 2 (R2 = .21 p < .003; N = 66) and treatment 4 (R2 = .27 p < .0004; N = 67). The model remained significant at these time points even when randomization status (titrated moderately suprathreshold vs. high fixed dosage) was removed (Treatment 2: R2 = .18 p < .007; Treatment 4: R2 = .23 p < .0007). Conclusion: EEG markers of seizure adequacy, including EEG seizure duration, are modestly predictive of antidepressant response for both titrated moderately suprathreshold and high fixed dosage RUL ECT.
KW - Antidepressant response
KW - Depression
KW - ECT
KW - Electroconvulsive therapy
KW - Major depression
KW - ROC curves
KW - Seizure duration
KW - Seizure threshold
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U2 - 10.1016/j.jad.2008.03.030
DO - 10.1016/j.jad.2008.03.030
M3 - Article
C2 - 18539340
AN - SCOPUS:56349152184
SN - 0165-0327
VL - 112
SP - 85
EP - 91
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1-3
ER -