Prediction of cervical histologic results using an abbreviated Reid Colposcopic Index during ALTS

Daron G. Ferris, Mark S. Litaker

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Objective: The purpose of this study was to determine the accuracy of an abbreviated Reid Colposcopic Index (RCI) to detect cervical intraepithelial neoplasia (CIN) 2 and CIN 3 during the National Cancer Institute (NCI) ASCUS LSIL Triage Study (ALTS). Study design: Colposcopists from 4 ALTS clinical centers indicated an RCI score after colposcopically examining subjects. Colposcopy quality control reviewers also documented an RCI score for the same subjects after assessing their digitized cervical images. Associations of colposcopist and reviewer RCI scores with histologic results were evaluated. Agreement rates between colposcopists and reviewers were calculated for colposcopic impression. Results: Overall RCI score agreement was poor (weighted Kappa = 0.17). The sensitivity, specificity, positive and negative predictive values of a colposcopist's RCI score of >3/6 to detect CIN 3 or worse were 37.3% (95% CI 32.5%-42.3%), 89.7% (88.6%-90.8%), 30.8% (26.7%-35.2%), and 92.1% (91.1%-93.0%), respectively. The 3 colposcopic signs were not individually sensitive in detecting CIN 3. Conclusion: Colposcopists using the RCI in the ALTS trial failed to detect CIN 2/3 at the levels expected.

Original languageEnglish (US)
Pages (from-to)704-710
Number of pages7
JournalAmerican journal of obstetrics and gynecology
Volume194
Issue number3
DOIs
StatePublished - Mar 1 2006

Fingerprint

Cervical Intraepithelial Neoplasia
Triage
Colposcopy
National Cancer Institute (U.S.)
Quality Control
Atypical Squamous Cells of the Cervix
Sensitivity and Specificity

Keywords

  • Cervical neoplasia
  • Colposcopy
  • Reid Colposcopic Index

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Prediction of cervical histologic results using an abbreviated Reid Colposcopic Index during ALTS. / Ferris, Daron G.; Litaker, Mark S.

In: American journal of obstetrics and gynecology, Vol. 194, No. 3, 01.03.2006, p. 704-710.

Research output: Contribution to journalArticle

@article{7b71eacde85d4b6bb89fa2068a40ac78,
title = "Prediction of cervical histologic results using an abbreviated Reid Colposcopic Index during ALTS",
abstract = "Objective: The purpose of this study was to determine the accuracy of an abbreviated Reid Colposcopic Index (RCI) to detect cervical intraepithelial neoplasia (CIN) 2 and CIN 3 during the National Cancer Institute (NCI) ASCUS LSIL Triage Study (ALTS). Study design: Colposcopists from 4 ALTS clinical centers indicated an RCI score after colposcopically examining subjects. Colposcopy quality control reviewers also documented an RCI score for the same subjects after assessing their digitized cervical images. Associations of colposcopist and reviewer RCI scores with histologic results were evaluated. Agreement rates between colposcopists and reviewers were calculated for colposcopic impression. Results: Overall RCI score agreement was poor (weighted Kappa = 0.17). The sensitivity, specificity, positive and negative predictive values of a colposcopist's RCI score of >3/6 to detect CIN 3 or worse were 37.3{\%} (95{\%} CI 32.5{\%}-42.3{\%}), 89.7{\%} (88.6{\%}-90.8{\%}), 30.8{\%} (26.7{\%}-35.2{\%}), and 92.1{\%} (91.1{\%}-93.0{\%}), respectively. The 3 colposcopic signs were not individually sensitive in detecting CIN 3. Conclusion: Colposcopists using the RCI in the ALTS trial failed to detect CIN 2/3 at the levels expected.",
keywords = "Cervical neoplasia, Colposcopy, Reid Colposcopic Index",
author = "Ferris, {Daron G.} and Litaker, {Mark S.}",
year = "2006",
month = "3",
day = "1",
doi = "10.1016/j.ajog.2005.10.204",
language = "English (US)",
volume = "194",
pages = "704--710",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Prediction of cervical histologic results using an abbreviated Reid Colposcopic Index during ALTS

AU - Ferris, Daron G.

AU - Litaker, Mark S.

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Objective: The purpose of this study was to determine the accuracy of an abbreviated Reid Colposcopic Index (RCI) to detect cervical intraepithelial neoplasia (CIN) 2 and CIN 3 during the National Cancer Institute (NCI) ASCUS LSIL Triage Study (ALTS). Study design: Colposcopists from 4 ALTS clinical centers indicated an RCI score after colposcopically examining subjects. Colposcopy quality control reviewers also documented an RCI score for the same subjects after assessing their digitized cervical images. Associations of colposcopist and reviewer RCI scores with histologic results were evaluated. Agreement rates between colposcopists and reviewers were calculated for colposcopic impression. Results: Overall RCI score agreement was poor (weighted Kappa = 0.17). The sensitivity, specificity, positive and negative predictive values of a colposcopist's RCI score of >3/6 to detect CIN 3 or worse were 37.3% (95% CI 32.5%-42.3%), 89.7% (88.6%-90.8%), 30.8% (26.7%-35.2%), and 92.1% (91.1%-93.0%), respectively. The 3 colposcopic signs were not individually sensitive in detecting CIN 3. Conclusion: Colposcopists using the RCI in the ALTS trial failed to detect CIN 2/3 at the levels expected.

AB - Objective: The purpose of this study was to determine the accuracy of an abbreviated Reid Colposcopic Index (RCI) to detect cervical intraepithelial neoplasia (CIN) 2 and CIN 3 during the National Cancer Institute (NCI) ASCUS LSIL Triage Study (ALTS). Study design: Colposcopists from 4 ALTS clinical centers indicated an RCI score after colposcopically examining subjects. Colposcopy quality control reviewers also documented an RCI score for the same subjects after assessing their digitized cervical images. Associations of colposcopist and reviewer RCI scores with histologic results were evaluated. Agreement rates between colposcopists and reviewers were calculated for colposcopic impression. Results: Overall RCI score agreement was poor (weighted Kappa = 0.17). The sensitivity, specificity, positive and negative predictive values of a colposcopist's RCI score of >3/6 to detect CIN 3 or worse were 37.3% (95% CI 32.5%-42.3%), 89.7% (88.6%-90.8%), 30.8% (26.7%-35.2%), and 92.1% (91.1%-93.0%), respectively. The 3 colposcopic signs were not individually sensitive in detecting CIN 3. Conclusion: Colposcopists using the RCI in the ALTS trial failed to detect CIN 2/3 at the levels expected.

KW - Cervical neoplasia

KW - Colposcopy

KW - Reid Colposcopic Index

UR - http://www.scopus.com/inward/record.url?scp=33644692051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644692051&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2005.10.204

DO - 10.1016/j.ajog.2005.10.204

M3 - Article

C2 - 16522401

AN - SCOPUS:33644692051

VL - 194

SP - 704

EP - 710

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 3

ER -