TY - JOUR
T1 - Prediction of left ventricular mass in youth with family histories of essential hypertension
AU - Murdison, Kenneth A.
AU - Treiber, Frank A.
AU - Mensah, George
AU - Davis, Harry
AU - Thompson, William
AU - Strong, William B.
N1 - Funding Information:
Received August 1, 1997; accepted in revised form October 22, 1997. Correspondence: Frank A. Treiber, PhD, Medical College of Georgia, Georgia Prevention Institute, Building HS 1640, Augusta, GA 30912-3710. This study was supported in part by Grant HL-41781 from the National Institutes of Health. Portions of this paper were presented at the Southern American Federation for Clinical Research in February 1997 (abstract: J Invest Med 1997;45;4A),
PY - 1998
Y1 - 1998
N2 - To determine predictors of left ventricular mass (LVM) and hypertrophy (LVH), 56 black and 30 white normotensive healthy youths (mean age 12.6 ± 2.3 years at initial visit) were studied twice, 2.5 years apart. During the initial visit, anthropometric variables and hemodynamics were measured at rest and before, during, and after 4 physical and behavioral stressors. 2-D directed M-mode echocardiography was performed to derive LVM. Hierarchical multiple regression analyses indicated that follow-up LVM was predicted by initial LVM, weight, height (ht), and gender (males > females; total model R2 = 0.77, P < 0.0001). Predictors of LVM/ht2.7 were initial LVM/ht2.7, weight, ethnicity (blacks > whites), and the aggregate index of blood pressure reactivity (total model R2 = 0.66, P < 0.0001). Youth with LVH at follow-up were taller, heavier, and exhibited greater blood pressure reactivity at initial evaluation. These findings are important since interventional strategies can be developed that target obesity and exaggerated reactivity to stress.
AB - To determine predictors of left ventricular mass (LVM) and hypertrophy (LVH), 56 black and 30 white normotensive healthy youths (mean age 12.6 ± 2.3 years at initial visit) were studied twice, 2.5 years apart. During the initial visit, anthropometric variables and hemodynamics were measured at rest and before, during, and after 4 physical and behavioral stressors. 2-D directed M-mode echocardiography was performed to derive LVM. Hierarchical multiple regression analyses indicated that follow-up LVM was predicted by initial LVM, weight, height (ht), and gender (males > females; total model R2 = 0.77, P < 0.0001). Predictors of LVM/ht2.7 were initial LVM/ht2.7, weight, ethnicity (blacks > whites), and the aggregate index of blood pressure reactivity (total model R2 = 0.66, P < 0.0001). Youth with LVH at follow-up were taller, heavier, and exhibited greater blood pressure reactivity at initial evaluation. These findings are important since interventional strategies can be developed that target obesity and exaggerated reactivity to stress.
KW - Cardiovascular reactivity
KW - Left ventricular mass
KW - Prediction
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U2 - 10.1097/00000441-199802000-00008
DO - 10.1097/00000441-199802000-00008
M3 - Article
C2 - 9472911
AN - SCOPUS:0031889514
VL - 315
SP - 118
EP - 123
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 2
ER -