Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders

Diana O. Perkins, Jeffrey A. Lieberman, Hongbin Gu, Mauricio Tohen, Joseph Patrick McEvoy, Alan I. Green, Robert B. Zipursky, Stephen M. Strakowski, Tonmoy Sharma, René S. Kahn, Raquel Gur, Gary Tollefson

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Background: Duration of untreated psychosis (DUP) may contribute to the observed heterogeneity of the treatment response in first-episode schizophrenia. Aims: To examine the relationship of DUP and premorbid function with clinical outcomes following up to 2 years of antipsychotic treatment. Method: For a subsample (n=191) of subjects participating in a clinical trial, DUP and premorbid function were prospectively compared with clinical response to olanzapine or haloperidol. Results: Shorter DUP and good premorbid function each independently are associated with better clinical response, including improvement in overall psychopathology and negative symptoms. Premorbid function also is associated with positive symptom, social and vocational outcomes. Conclusions: Earlier antipsychotic treatment is associated with better outcomes in first-episode schizophrenia. Poor premorbid function could indicate an illness subtype less likely to respond to antipsychotic treatment regardless of when it is instituted.

Original languageEnglish (US)
Pages (from-to)18-24
Number of pages7
JournalBritish Journal of Psychiatry
Volume185
Issue numberJULY
DOIs
StatePublished - Jul 1 2004

Fingerprint

Psychotic Disorders
Antipsychotic Agents
Schizophrenia
olanzapine
Haloperidol
Therapeutics
Psychopathology
Clinical Trials

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders. / Perkins, Diana O.; Lieberman, Jeffrey A.; Gu, Hongbin; Tohen, Mauricio; McEvoy, Joseph Patrick; Green, Alan I.; Zipursky, Robert B.; Strakowski, Stephen M.; Sharma, Tonmoy; Kahn, René S.; Gur, Raquel; Tollefson, Gary.

In: British Journal of Psychiatry, Vol. 185, No. JULY, 01.07.2004, p. 18-24.

Research output: Contribution to journalArticle

Perkins, DO, Lieberman, JA, Gu, H, Tohen, M, McEvoy, JP, Green, AI, Zipursky, RB, Strakowski, SM, Sharma, T, Kahn, RS, Gur, R & Tollefson, G 2004, 'Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders', British Journal of Psychiatry, vol. 185, no. JULY, pp. 18-24. https://doi.org/10.1192/bjp.185.1.18
Perkins, Diana O. ; Lieberman, Jeffrey A. ; Gu, Hongbin ; Tohen, Mauricio ; McEvoy, Joseph Patrick ; Green, Alan I. ; Zipursky, Robert B. ; Strakowski, Stephen M. ; Sharma, Tonmoy ; Kahn, René S. ; Gur, Raquel ; Tollefson, Gary. / Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders. In: British Journal of Psychiatry. 2004 ; Vol. 185, No. JULY. pp. 18-24.
@article{00d62dd72f4840729269c4eb89c4cf3a,
title = "Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders",
abstract = "Background: Duration of untreated psychosis (DUP) may contribute to the observed heterogeneity of the treatment response in first-episode schizophrenia. Aims: To examine the relationship of DUP and premorbid function with clinical outcomes following up to 2 years of antipsychotic treatment. Method: For a subsample (n=191) of subjects participating in a clinical trial, DUP and premorbid function were prospectively compared with clinical response to olanzapine or haloperidol. Results: Shorter DUP and good premorbid function each independently are associated with better clinical response, including improvement in overall psychopathology and negative symptoms. Premorbid function also is associated with positive symptom, social and vocational outcomes. Conclusions: Earlier antipsychotic treatment is associated with better outcomes in first-episode schizophrenia. Poor premorbid function could indicate an illness subtype less likely to respond to antipsychotic treatment regardless of when it is instituted.",
author = "Perkins, {Diana O.} and Lieberman, {Jeffrey A.} and Hongbin Gu and Mauricio Tohen and McEvoy, {Joseph Patrick} and Green, {Alan I.} and Zipursky, {Robert B.} and Strakowski, {Stephen M.} and Tonmoy Sharma and Kahn, {Ren{\'e} S.} and Raquel Gur and Gary Tollefson",
year = "2004",
month = "7",
day = "1",
doi = "10.1192/bjp.185.1.18",
language = "English (US)",
volume = "185",
pages = "18--24",
journal = "British Journal of Psychiatry",
issn = "0007-1250",
publisher = "Royal College of Psychiatrists",
number = "JULY",

}

TY - JOUR

T1 - Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders

AU - Perkins, Diana O.

AU - Lieberman, Jeffrey A.

AU - Gu, Hongbin

AU - Tohen, Mauricio

AU - McEvoy, Joseph Patrick

AU - Green, Alan I.

AU - Zipursky, Robert B.

AU - Strakowski, Stephen M.

AU - Sharma, Tonmoy

AU - Kahn, René S.

AU - Gur, Raquel

AU - Tollefson, Gary

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Background: Duration of untreated psychosis (DUP) may contribute to the observed heterogeneity of the treatment response in first-episode schizophrenia. Aims: To examine the relationship of DUP and premorbid function with clinical outcomes following up to 2 years of antipsychotic treatment. Method: For a subsample (n=191) of subjects participating in a clinical trial, DUP and premorbid function were prospectively compared with clinical response to olanzapine or haloperidol. Results: Shorter DUP and good premorbid function each independently are associated with better clinical response, including improvement in overall psychopathology and negative symptoms. Premorbid function also is associated with positive symptom, social and vocational outcomes. Conclusions: Earlier antipsychotic treatment is associated with better outcomes in first-episode schizophrenia. Poor premorbid function could indicate an illness subtype less likely to respond to antipsychotic treatment regardless of when it is instituted.

AB - Background: Duration of untreated psychosis (DUP) may contribute to the observed heterogeneity of the treatment response in first-episode schizophrenia. Aims: To examine the relationship of DUP and premorbid function with clinical outcomes following up to 2 years of antipsychotic treatment. Method: For a subsample (n=191) of subjects participating in a clinical trial, DUP and premorbid function were prospectively compared with clinical response to olanzapine or haloperidol. Results: Shorter DUP and good premorbid function each independently are associated with better clinical response, including improvement in overall psychopathology and negative symptoms. Premorbid function also is associated with positive symptom, social and vocational outcomes. Conclusions: Earlier antipsychotic treatment is associated with better outcomes in first-episode schizophrenia. Poor premorbid function could indicate an illness subtype less likely to respond to antipsychotic treatment regardless of when it is instituted.

UR - http://www.scopus.com/inward/record.url?scp=3242687762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242687762&partnerID=8YFLogxK

U2 - 10.1192/bjp.185.1.18

DO - 10.1192/bjp.185.1.18

M3 - Article

C2 - 15231551

AN - SCOPUS:3242687762

VL - 185

SP - 18

EP - 24

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - JULY

ER -