Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis

12-month randomized trial

Alex Nogueira Haas, Carina Maciel Silva-Boghossian, Ana Paula Colombo, Jasim Albandar, Rui Vicente Oppermann, Cassiano Kuchenbecker Rösing, Cristiano Susin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Little is known about the factors that may be used in clinical practice to predict the therapeutic response of aggressive periodontitis patients. The aim of this study was to determine predictors of clinical outcomes after non-surgical treatment of aggressive periodontitis. A total of 24 patients (aged 13-26 years) received oral hygiene instructions, as well as subgingival scaling and root planing. Twelve subjects received systemic azithromycin at random. Clinical variables were assessed at baseline, 3, 6, 9, and 12 months. Baseline microbiological assessment was performed by checkerboard DNA-DNA hybridization. Multivariable models used generalized estimating equations. There were significant improvements in the entire sample in regard to pocket depth, clinical attachment level and bleeding on probing. Significant predictors of a reduction in mean pocket depth were: use of azithromycin, non-molar teeth, generalized disease and baseline pocket depth. Absence of plaque predicted a 0.22 mm higher attachment gain, whereas a baseline pocket depth ≥7 mm predicted a 1.36 mm higher attachment loss. Azithromycin, plaque, and baseline pocket depth were significant predictors of bleeding on probing. The concomitant presence of all three red complex species predicted a 0.78 mm higher attachment loss. It may be concluded that dental plaque, tooth type, disease extent, baseline pocket depth, and use of azithromycin were significant predictors of the clinical response to treatment for aggressive periodontitis in young individuals. Moreover, the presence of multiple periodontal pathogens may predict challenges in achieving a favorable outcome for aggressive periodontitis.

Original languageEnglish (US)
JournalBrazilian oral research
Volume30
Issue number1
DOIs
StatePublished - May 20 2016

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Aggressive Periodontitis
Azithromycin
Tooth Diseases
Dental Scaling
Root Planing
Hemorrhage
Dental Plaque
Oral Hygiene
DNA
Therapeutics

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Haas, A. N., Silva-Boghossian, C. M., Colombo, A. P., Albandar, J., Oppermann, R. V., Rösing, C. K., & Susin, C. (2016). Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis: 12-month randomized trial. Brazilian oral research, 30(1). https://doi.org/10.1590/1807-3107BOR-2016.vol30.0041

Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis : 12-month randomized trial. / Haas, Alex Nogueira; Silva-Boghossian, Carina Maciel; Colombo, Ana Paula; Albandar, Jasim; Oppermann, Rui Vicente; Rösing, Cassiano Kuchenbecker; Susin, Cristiano.

In: Brazilian oral research, Vol. 30, No. 1, 20.05.2016.

Research output: Contribution to journalArticle

Haas, Alex Nogueira ; Silva-Boghossian, Carina Maciel ; Colombo, Ana Paula ; Albandar, Jasim ; Oppermann, Rui Vicente ; Rösing, Cassiano Kuchenbecker ; Susin, Cristiano. / Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis : 12-month randomized trial. In: Brazilian oral research. 2016 ; Vol. 30, No. 1.
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