Predictors of surgical outcome in medically-resistant temporal lobe epilepsy with bilateral features on pre-operative evaluation

Hena Waseem, Katie E. Osborn, Mike R. Schoenberg, Valerie Kelley, Ali M. Bozorg, Selim R. Benbadis, Fernando Vale Diaz

Research output: Contribution to journalArticle

Abstract

Objective This study identifies potential prognostic factors for favorable anterior mesial temporal lobe (AMTL) resection outcomes in patients with medically refractory temporal lobe epilepsy (TLE) with bilateral features on pre-operative examination. Methods Thirty-one patients demonstrated bilateral features defined as: bilateral independent temporal or bitemporal ictal onsets on surface or intracranial EEG, or bitemporal interictal epileptiform abnormalities on surface EEG with bilateral radiographic mesial temporal sclerosis. Surgical outcomes were classified according to reduction in seizure frequency: I (100% reduction), II (≥75% reduction), III (50-74% reduction), IV (<50% reduction). Results Of 31 patients, 14 (45%) improved to class I and 9 (29%) had a class II outcome at an average of 4 years after surgery. Eight (26%) patients did not exhibit good surgical outcome (class III, class IV). We found that neuropsychological and Wada memory scores were significantly correlated (p < 0.05) with surgical outcome, and logistic regression found neuropsychological evaluation significantly predicted better surgical outcome (p < 0.05). Conclusions When bilateral features are present on pre-operative evaluation, neuropsychological and Wada test results can provide unique data to better identify those patients more likely to achieve substantial seizure reduction.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalClinical Neurology and Neurosurgery
Volume139
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Temporal Lobe Epilepsy
Seizures
Neuropsychological Tests
Sclerosis
Temporal Lobe
Electroencephalography
Logistic Models
Stroke

Keywords

  • Bitemporal seizures
  • Epilepsy surgery
  • Intractable epilepsy
  • Neuropsychology
  • Seizure disorder
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Predictors of surgical outcome in medically-resistant temporal lobe epilepsy with bilateral features on pre-operative evaluation. / Waseem, Hena; Osborn, Katie E.; Schoenberg, Mike R.; Kelley, Valerie; Bozorg, Ali M.; Benbadis, Selim R.; Vale Diaz, Fernando.

In: Clinical Neurology and Neurosurgery, Vol. 139, 01.01.2015, p. 199-205.

Research output: Contribution to journalArticle

Waseem, Hena ; Osborn, Katie E. ; Schoenberg, Mike R. ; Kelley, Valerie ; Bozorg, Ali M. ; Benbadis, Selim R. ; Vale Diaz, Fernando. / Predictors of surgical outcome in medically-resistant temporal lobe epilepsy with bilateral features on pre-operative evaluation. In: Clinical Neurology and Neurosurgery. 2015 ; Vol. 139. pp. 199-205.
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abstract = "Objective This study identifies potential prognostic factors for favorable anterior mesial temporal lobe (AMTL) resection outcomes in patients with medically refractory temporal lobe epilepsy (TLE) with bilateral features on pre-operative examination. Methods Thirty-one patients demonstrated bilateral features defined as: bilateral independent temporal or bitemporal ictal onsets on surface or intracranial EEG, or bitemporal interictal epileptiform abnormalities on surface EEG with bilateral radiographic mesial temporal sclerosis. Surgical outcomes were classified according to reduction in seizure frequency: I (100{\%} reduction), II (≥75{\%} reduction), III (50-74{\%} reduction), IV (<50{\%} reduction). Results Of 31 patients, 14 (45{\%}) improved to class I and 9 (29{\%}) had a class II outcome at an average of 4 years after surgery. Eight (26{\%}) patients did not exhibit good surgical outcome (class III, class IV). We found that neuropsychological and Wada memory scores were significantly correlated (p < 0.05) with surgical outcome, and logistic regression found neuropsychological evaluation significantly predicted better surgical outcome (p < 0.05). Conclusions When bilateral features are present on pre-operative evaluation, neuropsychological and Wada test results can provide unique data to better identify those patients more likely to achieve substantial seizure reduction.",
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AB - Objective This study identifies potential prognostic factors for favorable anterior mesial temporal lobe (AMTL) resection outcomes in patients with medically refractory temporal lobe epilepsy (TLE) with bilateral features on pre-operative examination. Methods Thirty-one patients demonstrated bilateral features defined as: bilateral independent temporal or bitemporal ictal onsets on surface or intracranial EEG, or bitemporal interictal epileptiform abnormalities on surface EEG with bilateral radiographic mesial temporal sclerosis. Surgical outcomes were classified according to reduction in seizure frequency: I (100% reduction), II (≥75% reduction), III (50-74% reduction), IV (<50% reduction). Results Of 31 patients, 14 (45%) improved to class I and 9 (29%) had a class II outcome at an average of 4 years after surgery. Eight (26%) patients did not exhibit good surgical outcome (class III, class IV). We found that neuropsychological and Wada memory scores were significantly correlated (p < 0.05) with surgical outcome, and logistic regression found neuropsychological evaluation significantly predicted better surgical outcome (p < 0.05). Conclusions When bilateral features are present on pre-operative evaluation, neuropsychological and Wada test results can provide unique data to better identify those patients more likely to achieve substantial seizure reduction.

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