Preferential loss of maternal alleles in sporadic Wilms' tumour

N. Pal, R. B. Wadey, B. Buckle, E. Yeomans, J. Pritchard, John Kenneth Cowell

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Loss of heterozygosity at loci on the short arm of chromosome 11 has been reported in 31% (11/38) of Wilms' tumours in our series. Lymphoblastoid cell lines were prepared from the parents of 10/11 of the patients showing allele loss in their tumours. In 9 of the cases, where the parental origin of the alleles could be followed, it was the paternal alleles which were retained in the tumour. This preferential loss of the maternal alleles implies a role for genomic imprinting in the pathogenesis of Wilms' tumour.

Original languageEnglish (US)
Pages (from-to)1665-1668
Number of pages4
JournalOncogene
Volume5
Issue number11
StatePublished - Dec 14 1990
Externally publishedYes

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Wilms Tumor
Alleles
Mothers
Genomic Imprinting
Chromosomes, Human, Pair 11
Loss of Heterozygosity
Neoplasms
Parents
Cell Line

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Pal, N., Wadey, R. B., Buckle, B., Yeomans, E., Pritchard, J., & Cowell, J. K. (1990). Preferential loss of maternal alleles in sporadic Wilms' tumour. Oncogene, 5(11), 1665-1668.

Preferential loss of maternal alleles in sporadic Wilms' tumour. / Pal, N.; Wadey, R. B.; Buckle, B.; Yeomans, E.; Pritchard, J.; Cowell, John Kenneth.

In: Oncogene, Vol. 5, No. 11, 14.12.1990, p. 1665-1668.

Research output: Contribution to journalArticle

Pal, N, Wadey, RB, Buckle, B, Yeomans, E, Pritchard, J & Cowell, JK 1990, 'Preferential loss of maternal alleles in sporadic Wilms' tumour', Oncogene, vol. 5, no. 11, pp. 1665-1668.
Pal N, Wadey RB, Buckle B, Yeomans E, Pritchard J, Cowell JK. Preferential loss of maternal alleles in sporadic Wilms' tumour. Oncogene. 1990 Dec 14;5(11):1665-1668.
Pal, N. ; Wadey, R. B. ; Buckle, B. ; Yeomans, E. ; Pritchard, J. ; Cowell, John Kenneth. / Preferential loss of maternal alleles in sporadic Wilms' tumour. In: Oncogene. 1990 ; Vol. 5, No. 11. pp. 1665-1668.
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