Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome

Mark O. Goodarzi, Heath J. Antoine, Marita Pall, Jinrui Cui, Xiuqing Guo, Ricardo Azziz

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Abstract

In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3β (GSK3B) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3β contributes to the pathophysiology and inherited basis of PCOS.

Original languageEnglish (US)
Pages (from-to)1473-1476
Number of pages4
JournalFertility and sterility
Volume87
Issue number6
DOIs
StatePublished - Jun 1 2007

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ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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