Preliminary Findings

25(OH)D Levels and PTH Are Indicators of Rapid Bone Accrual in Pubertal Children

Frances A. Tylavsky, Kathryn M. Ryder, Rongling Li, Vicki Park, Catherine Womack, John Norwood, Laura D Carbone, Sulin Cheng

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: The objective of this study was to evaluate the role of serum levels of 25(OH)D and PTH on the accumulation of whole body bone mass in a cohort of children. Methods: This was a longitudinal study (1.98 ± 0.07 y) of sixty-nine children (89% Caucasian, 44% male) enrolled in a calcium supplementation trial. Bone area, bone mineral content (BMC) and density (BMD) of the whole body and radius were assessed using a QDR 2000 (Hologic, Inc) dual energy x-ray absorptiometer. Serum PTH and 25(OH)D were measured using radioimmunoassays. Results: Vitamin D stores were inversely related gain in bone area (p < 0.002), BMC (p < 0.002) BMD (p < 0.027), as well as to PTH levels (p < 0.0001). Compared to those with adequate vitamin D stores (>34 ng/ml), those who had consistently low vitamin D stores (18 ng/ml) had a 8% larger gain in bone area (p < 0.05); 11% in BMC (p < 0.05) and no differences in gain in BMD; after adjusting for baseline bone measurements, race, gender, season measured, Tanner stage, and calcium intake. Conclusions: High normal PTH with low-normal 25(OH)D stores and moderate to high calcium intake may be beneficial to accruing larger bone size and BMC during puberty.

Original languageEnglish (US)
Pages (from-to)462-470
Number of pages9
JournalJournal of the American College of Nutrition
Volume26
Issue number5
DOIs
StatePublished - Oct 1 2007

Fingerprint

Bone and Bones
Bone Density
Calcium
Vitamin D
Puberty
Serum
Radioimmunoassay
Longitudinal Studies
X-Rays

Keywords

  • Bone mass
  • Children
  • Dual energy x-ray absorptiometry
  • Parathyroid hormone
  • Vitamin D

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Preliminary Findings : 25(OH)D Levels and PTH Are Indicators of Rapid Bone Accrual in Pubertal Children. / Tylavsky, Frances A.; Ryder, Kathryn M.; Li, Rongling; Park, Vicki; Womack, Catherine; Norwood, John; Carbone, Laura D; Cheng, Sulin.

In: Journal of the American College of Nutrition, Vol. 26, No. 5, 01.10.2007, p. 462-470.

Research output: Contribution to journalArticle

Tylavsky, Frances A. ; Ryder, Kathryn M. ; Li, Rongling ; Park, Vicki ; Womack, Catherine ; Norwood, John ; Carbone, Laura D ; Cheng, Sulin. / Preliminary Findings : 25(OH)D Levels and PTH Are Indicators of Rapid Bone Accrual in Pubertal Children. In: Journal of the American College of Nutrition. 2007 ; Vol. 26, No. 5. pp. 462-470.
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