Preliminary Findings: 25(OH)D Levels and PTH Are Indicators of Rapid Bone Accrual in Pubertal Children

Frances A. Tylavsky, Kathryn M. Ryder, Rongling Li, Vicki Park, Catherine Womack, John Norwood, Laura D. Carbone, Sulin Cheng

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28 Scopus citations

Abstract

Objective: The objective of this study was to evaluate the role of serum levels of 25(OH)D and PTH on the accumulation of whole body bone mass in a cohort of children. Methods: This was a longitudinal study (1.98 ± 0.07 y) of sixty-nine children (89% Caucasian, 44% male) enrolled in a calcium supplementation trial. Bone area, bone mineral content (BMC) and density (BMD) of the whole body and radius were assessed using a QDR 2000 (Hologic, Inc) dual energy x-ray absorptiometer. Serum PTH and 25(OH)D were measured using radioimmunoassays. Results: Vitamin D stores were inversely related gain in bone area (p < 0.002), BMC (p < 0.002) BMD (p < 0.027), as well as to PTH levels (p < 0.0001). Compared to those with adequate vitamin D stores (>34 ng/ml), those who had consistently low vitamin D stores (18 ng/ml) had a 8% larger gain in bone area (p < 0.05); 11% in BMC (p < 0.05) and no differences in gain in BMD; after adjusting for baseline bone measurements, race, gender, season measured, Tanner stage, and calcium intake. Conclusions: High normal PTH with low-normal 25(OH)D stores and moderate to high calcium intake may be beneficial to accruing larger bone size and BMC during puberty.

Original languageEnglish (US)
Pages (from-to)462-470
Number of pages9
JournalJournal of the American College of Nutrition
Volume26
Issue number5
DOIs
Publication statusPublished - Oct 1 2007
Externally publishedYes

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Keywords

  • Bone mass
  • Children
  • Dual energy x-ray absorptiometry
  • Parathyroid hormone
  • Vitamin D

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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