Prenatal and infant nutrition in the pathogenesis of type 1 diabetes implications for diagnosis and therapy

Andrew Muir, Jin-Xiong She

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The concept of type 1 diabetes as a disease of childhood and adolescence is being challenged by studies that relate islet autoimmunity to prenatal and infantile determinants (1-5). Recent discoveries that increased maternal age (6,7), ABO incompatibility (8), and rapid postnatal growth (9-11) are all diabetes risk factors suggest that the pathogenic process starts very early in life. Interactions among protective and predisposing genes, environmental exposures, and immunological responses all appear necessary for the initiation and propagation of autoimmune T-lymphocyte responses that destroy the insulin-producing pancreatic beta cells. This chapter will review the current understanding of the pathogenesis of type 1 diabetes and highlight the contribution of infant nutrition to the initiation of progression of autoimmunity.

Original languageEnglish (US)
Title of host publicationPerinatal Nutrition
Subtitle of host publicationOptimizing Infant Health and Development
PublisherCRC Press
Pages307-330
Number of pages24
ISBN (Electronic)9780203997338
ISBN (Print)9780824754747
StatePublished - Jan 1 2004

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Autoimmunity
Type 1 Diabetes Mellitus
Environmental Exposure
Maternal Age
Insulin-Secreting Cells
Insulin
T-Lymphocytes
Therapeutics
Growth
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Muir, A., & She, J-X. (2004). Prenatal and infant nutrition in the pathogenesis of type 1 diabetes implications for diagnosis and therapy. In Perinatal Nutrition: Optimizing Infant Health and Development (pp. 307-330). CRC Press.

Prenatal and infant nutrition in the pathogenesis of type 1 diabetes implications for diagnosis and therapy. / Muir, Andrew; She, Jin-Xiong.

Perinatal Nutrition: Optimizing Infant Health and Development. CRC Press, 2004. p. 307-330.

Research output: Chapter in Book/Report/Conference proceedingChapter

Muir, A & She, J-X 2004, Prenatal and infant nutrition in the pathogenesis of type 1 diabetes implications for diagnosis and therapy. in Perinatal Nutrition: Optimizing Infant Health and Development. CRC Press, pp. 307-330.
Muir A, She J-X. Prenatal and infant nutrition in the pathogenesis of type 1 diabetes implications for diagnosis and therapy. In Perinatal Nutrition: Optimizing Infant Health and Development. CRC Press. 2004. p. 307-330
Muir, Andrew ; She, Jin-Xiong. / Prenatal and infant nutrition in the pathogenesis of type 1 diabetes implications for diagnosis and therapy. Perinatal Nutrition: Optimizing Infant Health and Development. CRC Press, 2004. pp. 307-330
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