Prenatal antimicrobial use and early-childhood body mass index

A. E. Cassidy-Bushrow, C. Burmeister, S. Havstad, A. M. Levin, S. V. Lynch, Dennis Randall Ownby, A. G. Rundle, K. J. Woodcroft, E. M. Zoratti, C. C. Johnson, G. Wegienka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/Objectives:Growing evidence suggests that antibiotic use is associated with childhood body mass index (BMI), potentially via mechanisms mediated by gut microbiome alterations. Less is known on the potential role of prenatal antimicrobial use in offspring obesity risk. We examined whether prenatal antibiotic or antifungal use was associated with BMI at the age of 2 years in 527 birth cohort participants.Methods/Subjects:Antimicrobial use was obtained from the prenatal medical record. Height and weight were measured at the age of 2 years. Overweight/obesity was defined as a BMI ≥85th percentile.Results:A total of 303 (57.5%) women used antibiotics and 101 (19.2%) used antifungals during pregnancy. Prenatal antifungal use was not associated with child BMI at the age of 2 years. In the fully adjusted model, prenatal antibiotic use was associated with a 0.20±0.10 (P=0.046) higher mean BMI Z-score at the age of 2 years. Associations between prenatal antibiotic use and childhood BMI varied by trimester of exposure, with first or second-trimester exposure more strongly associated with larger BMI at the age of 2 years for both BMI Z-score (interaction P=0.032) and overweight/obesity (interaction P=0.098) after covariate adjustment.Conclusions:Prenatal antibiotic, but not antifungal, use is associated with larger BMI at the age of 2 years; associations were stronger for antibiotic exposures in earlier trimesters. Future studies examining whether these associations are due to alterations in the maternal and/or infant microbiome are necessary. Children who are overweight at the age of 2 years are at higher risk for being overweight as they age; prenatal antibiotic use is a potentially modifiable exposure that could reduce childhood obesity.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Obesity
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2018

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Body Mass Index
Anti-Bacterial Agents
Obesity
Antifungal Agents
Pediatric Obesity
Microbiota
Second Pregnancy Trimester
Medical Records
Mothers
Parturition
Weights and Measures
Pregnancy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Cassidy-Bushrow, A. E., Burmeister, C., Havstad, S., Levin, A. M., Lynch, S. V., Ownby, D. R., ... Wegienka, G. (2018). Prenatal antimicrobial use and early-childhood body mass index. International Journal of Obesity, 42(1), 1-7. https://doi.org/10.1038/ijo.2017.205

Prenatal antimicrobial use and early-childhood body mass index. / Cassidy-Bushrow, A. E.; Burmeister, C.; Havstad, S.; Levin, A. M.; Lynch, S. V.; Ownby, Dennis Randall; Rundle, A. G.; Woodcroft, K. J.; Zoratti, E. M.; Johnson, C. C.; Wegienka, G.

In: International Journal of Obesity, Vol. 42, No. 1, 01.01.2018, p. 1-7.

Research output: Contribution to journalArticle

Cassidy-Bushrow, AE, Burmeister, C, Havstad, S, Levin, AM, Lynch, SV, Ownby, DR, Rundle, AG, Woodcroft, KJ, Zoratti, EM, Johnson, CC & Wegienka, G 2018, 'Prenatal antimicrobial use and early-childhood body mass index', International Journal of Obesity, vol. 42, no. 1, pp. 1-7. https://doi.org/10.1038/ijo.2017.205
Cassidy-Bushrow AE, Burmeister C, Havstad S, Levin AM, Lynch SV, Ownby DR et al. Prenatal antimicrobial use and early-childhood body mass index. International Journal of Obesity. 2018 Jan 1;42(1):1-7. https://doi.org/10.1038/ijo.2017.205
Cassidy-Bushrow, A. E. ; Burmeister, C. ; Havstad, S. ; Levin, A. M. ; Lynch, S. V. ; Ownby, Dennis Randall ; Rundle, A. G. ; Woodcroft, K. J. ; Zoratti, E. M. ; Johnson, C. C. ; Wegienka, G. / Prenatal antimicrobial use and early-childhood body mass index. In: International Journal of Obesity. 2018 ; Vol. 42, No. 1. pp. 1-7.
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abstract = "Background/Objectives:Growing evidence suggests that antibiotic use is associated with childhood body mass index (BMI), potentially via mechanisms mediated by gut microbiome alterations. Less is known on the potential role of prenatal antimicrobial use in offspring obesity risk. We examined whether prenatal antibiotic or antifungal use was associated with BMI at the age of 2 years in 527 birth cohort participants.Methods/Subjects:Antimicrobial use was obtained from the prenatal medical record. Height and weight were measured at the age of 2 years. Overweight/obesity was defined as a BMI ≥85th percentile.Results:A total of 303 (57.5{\%}) women used antibiotics and 101 (19.2{\%}) used antifungals during pregnancy. Prenatal antifungal use was not associated with child BMI at the age of 2 years. In the fully adjusted model, prenatal antibiotic use was associated with a 0.20±0.10 (P=0.046) higher mean BMI Z-score at the age of 2 years. Associations between prenatal antibiotic use and childhood BMI varied by trimester of exposure, with first or second-trimester exposure more strongly associated with larger BMI at the age of 2 years for both BMI Z-score (interaction P=0.032) and overweight/obesity (interaction P=0.098) after covariate adjustment.Conclusions:Prenatal antibiotic, but not antifungal, use is associated with larger BMI at the age of 2 years; associations were stronger for antibiotic exposures in earlier trimesters. Future studies examining whether these associations are due to alterations in the maternal and/or infant microbiome are necessary. Children who are overweight at the age of 2 years are at higher risk for being overweight as they age; prenatal antibiotic use is a potentially modifiable exposure that could reduce childhood obesity.",
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AU - Rundle, A. G.

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AU - Wegienka, G.

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N2 - Background/Objectives:Growing evidence suggests that antibiotic use is associated with childhood body mass index (BMI), potentially via mechanisms mediated by gut microbiome alterations. Less is known on the potential role of prenatal antimicrobial use in offspring obesity risk. We examined whether prenatal antibiotic or antifungal use was associated with BMI at the age of 2 years in 527 birth cohort participants.Methods/Subjects:Antimicrobial use was obtained from the prenatal medical record. Height and weight were measured at the age of 2 years. Overweight/obesity was defined as a BMI ≥85th percentile.Results:A total of 303 (57.5%) women used antibiotics and 101 (19.2%) used antifungals during pregnancy. Prenatal antifungal use was not associated with child BMI at the age of 2 years. In the fully adjusted model, prenatal antibiotic use was associated with a 0.20±0.10 (P=0.046) higher mean BMI Z-score at the age of 2 years. Associations between prenatal antibiotic use and childhood BMI varied by trimester of exposure, with first or second-trimester exposure more strongly associated with larger BMI at the age of 2 years for both BMI Z-score (interaction P=0.032) and overweight/obesity (interaction P=0.098) after covariate adjustment.Conclusions:Prenatal antibiotic, but not antifungal, use is associated with larger BMI at the age of 2 years; associations were stronger for antibiotic exposures in earlier trimesters. Future studies examining whether these associations are due to alterations in the maternal and/or infant microbiome are necessary. Children who are overweight at the age of 2 years are at higher risk for being overweight as they age; prenatal antibiotic use is a potentially modifiable exposure that could reduce childhood obesity.

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