Prenatal exposure to household pets influences fetal immunoglobulin e production

N. Aichbhaumik, E. M. Zoratti, R. Strickler, G. Wegienka, Dennis Randall Ownby, S. Havstad, C. C. Johnson

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: Early life pet exposure may protect against allergic sensitization during childhood. Few studies have evaluated the effect of prenatal pet exposure on potential neonatal markers of allergic risk. Objective: The aim of this study was to investigate whether maternal exposure to pets affects cord blood IgE levels in a population-based, general risk, ethnically mixed birth cohort. Methods: Pet keeping during pregnancy was ascertained from women residing in a defined area of Wayne County Michigan and recruited from five staff model obstetric clinics. Maternal venous blood was analysed for total and allergen-specific IgE along with cord blood total IgE from 1049 infants. Results: Compared with infants from households with no cats or dogs kept indoors during pregnancy, infants whose homes had either cats or dogs had significantly reduced mean cord IgE levels [0.34 IU/mL (95% CI 0.30-0.38) vs. 0.24 IU/mL (0.20-0.27), P=0.025]. Similar effects were apparent in cat-only households [0.21 IU/mL (0.16-0.27), P=0.020] and dog-only households [0.24 IU/mL (0.19-0.29), P=0.045]. There was no effect on results when excluding mothers who reported avoiding pets due to allergy-related concerns. Conclusion: Mothers with either cats or dogs in their home during pregnancy deliver children with lower cord blood IgE levels compared with mothers who do not live with these pets, supporting the hypothesis that pet exposure influences immune development in a manner that is protective for atopy and is operant even before birth.

Original languageEnglish (US)
Pages (from-to)1787-1794
Number of pages8
JournalClinical and Experimental Allergy
Volume38
Issue number11
DOIs
StatePublished - Nov 1 2008

Fingerprint

Pets
Immunoglobulins
Immunoglobulin E
Cats
Fetal Blood
Mothers
Dogs
Pregnancy
Parturition
Maternal Exposure
Allergens
Obstetrics
Hypersensitivity
Population

Keywords

  • Allergy
  • Atopy
  • Cat
  • Cord blood
  • Dog
  • Fetal
  • IgE
  • Immune response pets
  • Pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Aichbhaumik, N., Zoratti, E. M., Strickler, R., Wegienka, G., Ownby, D. R., Havstad, S., & Johnson, C. C. (2008). Prenatal exposure to household pets influences fetal immunoglobulin e production. Clinical and Experimental Allergy, 38(11), 1787-1794. https://doi.org/10.1111/j.1365-2222.2008.03079.x

Prenatal exposure to household pets influences fetal immunoglobulin e production. / Aichbhaumik, N.; Zoratti, E. M.; Strickler, R.; Wegienka, G.; Ownby, Dennis Randall; Havstad, S.; Johnson, C. C.

In: Clinical and Experimental Allergy, Vol. 38, No. 11, 01.11.2008, p. 1787-1794.

Research output: Contribution to journalArticle

Aichbhaumik, N, Zoratti, EM, Strickler, R, Wegienka, G, Ownby, DR, Havstad, S & Johnson, CC 2008, 'Prenatal exposure to household pets influences fetal immunoglobulin e production', Clinical and Experimental Allergy, vol. 38, no. 11, pp. 1787-1794. https://doi.org/10.1111/j.1365-2222.2008.03079.x
Aichbhaumik, N. ; Zoratti, E. M. ; Strickler, R. ; Wegienka, G. ; Ownby, Dennis Randall ; Havstad, S. ; Johnson, C. C. / Prenatal exposure to household pets influences fetal immunoglobulin e production. In: Clinical and Experimental Allergy. 2008 ; Vol. 38, No. 11. pp. 1787-1794.
@article{318d76489ba0473a8d9e026df0130f16,
title = "Prenatal exposure to household pets influences fetal immunoglobulin e production",
abstract = "Background: Early life pet exposure may protect against allergic sensitization during childhood. Few studies have evaluated the effect of prenatal pet exposure on potential neonatal markers of allergic risk. Objective: The aim of this study was to investigate whether maternal exposure to pets affects cord blood IgE levels in a population-based, general risk, ethnically mixed birth cohort. Methods: Pet keeping during pregnancy was ascertained from women residing in a defined area of Wayne County Michigan and recruited from five staff model obstetric clinics. Maternal venous blood was analysed for total and allergen-specific IgE along with cord blood total IgE from 1049 infants. Results: Compared with infants from households with no cats or dogs kept indoors during pregnancy, infants whose homes had either cats or dogs had significantly reduced mean cord IgE levels [0.34 IU/mL (95{\%} CI 0.30-0.38) vs. 0.24 IU/mL (0.20-0.27), P=0.025]. Similar effects were apparent in cat-only households [0.21 IU/mL (0.16-0.27), P=0.020] and dog-only households [0.24 IU/mL (0.19-0.29), P=0.045]. There was no effect on results when excluding mothers who reported avoiding pets due to allergy-related concerns. Conclusion: Mothers with either cats or dogs in their home during pregnancy deliver children with lower cord blood IgE levels compared with mothers who do not live with these pets, supporting the hypothesis that pet exposure influences immune development in a manner that is protective for atopy and is operant even before birth.",
keywords = "Allergy, Atopy, Cat, Cord blood, Dog, Fetal, IgE, Immune response pets, Pregnancy",
author = "N. Aichbhaumik and Zoratti, {E. M.} and R. Strickler and G. Wegienka and Ownby, {Dennis Randall} and S. Havstad and Johnson, {C. C.}",
year = "2008",
month = "11",
day = "1",
doi = "10.1111/j.1365-2222.2008.03079.x",
language = "English (US)",
volume = "38",
pages = "1787--1794",
journal = "Clinical and Experimental Allergy",
issn = "0954-7894",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Prenatal exposure to household pets influences fetal immunoglobulin e production

AU - Aichbhaumik, N.

AU - Zoratti, E. M.

AU - Strickler, R.

AU - Wegienka, G.

AU - Ownby, Dennis Randall

AU - Havstad, S.

AU - Johnson, C. C.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Background: Early life pet exposure may protect against allergic sensitization during childhood. Few studies have evaluated the effect of prenatal pet exposure on potential neonatal markers of allergic risk. Objective: The aim of this study was to investigate whether maternal exposure to pets affects cord blood IgE levels in a population-based, general risk, ethnically mixed birth cohort. Methods: Pet keeping during pregnancy was ascertained from women residing in a defined area of Wayne County Michigan and recruited from five staff model obstetric clinics. Maternal venous blood was analysed for total and allergen-specific IgE along with cord blood total IgE from 1049 infants. Results: Compared with infants from households with no cats or dogs kept indoors during pregnancy, infants whose homes had either cats or dogs had significantly reduced mean cord IgE levels [0.34 IU/mL (95% CI 0.30-0.38) vs. 0.24 IU/mL (0.20-0.27), P=0.025]. Similar effects were apparent in cat-only households [0.21 IU/mL (0.16-0.27), P=0.020] and dog-only households [0.24 IU/mL (0.19-0.29), P=0.045]. There was no effect on results when excluding mothers who reported avoiding pets due to allergy-related concerns. Conclusion: Mothers with either cats or dogs in their home during pregnancy deliver children with lower cord blood IgE levels compared with mothers who do not live with these pets, supporting the hypothesis that pet exposure influences immune development in a manner that is protective for atopy and is operant even before birth.

AB - Background: Early life pet exposure may protect against allergic sensitization during childhood. Few studies have evaluated the effect of prenatal pet exposure on potential neonatal markers of allergic risk. Objective: The aim of this study was to investigate whether maternal exposure to pets affects cord blood IgE levels in a population-based, general risk, ethnically mixed birth cohort. Methods: Pet keeping during pregnancy was ascertained from women residing in a defined area of Wayne County Michigan and recruited from five staff model obstetric clinics. Maternal venous blood was analysed for total and allergen-specific IgE along with cord blood total IgE from 1049 infants. Results: Compared with infants from households with no cats or dogs kept indoors during pregnancy, infants whose homes had either cats or dogs had significantly reduced mean cord IgE levels [0.34 IU/mL (95% CI 0.30-0.38) vs. 0.24 IU/mL (0.20-0.27), P=0.025]. Similar effects were apparent in cat-only households [0.21 IU/mL (0.16-0.27), P=0.020] and dog-only households [0.24 IU/mL (0.19-0.29), P=0.045]. There was no effect on results when excluding mothers who reported avoiding pets due to allergy-related concerns. Conclusion: Mothers with either cats or dogs in their home during pregnancy deliver children with lower cord blood IgE levels compared with mothers who do not live with these pets, supporting the hypothesis that pet exposure influences immune development in a manner that is protective for atopy and is operant even before birth.

KW - Allergy

KW - Atopy

KW - Cat

KW - Cord blood

KW - Dog

KW - Fetal

KW - IgE

KW - Immune response pets

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=54849410642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54849410642&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2222.2008.03079.x

DO - 10.1111/j.1365-2222.2008.03079.x

M3 - Article

VL - 38

SP - 1787

EP - 1794

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

SN - 0954-7894

IS - 11

ER -