Presence of an early lineage stem cell phenotype in meningioma-initiating cells

Prakash Rath, James M. Wilson, Huidong Shi

Research output: Chapter in Book/Report/Conference proceedingChapter


Meningiomas are a common form of adult brain tumors. Although most meningiomas are benign tumors that are associated with favorable outcomes, a small group of patients develop more aggressive manifestations which currently are more difficult to treat. It has increasingly been recognized that tumor stem-like cells play critical roles in tumor recurrence, angiogenesis, and invasion in malignant brain tumors. Several recent studies identified the stem-like features of sphere-forming cells in human meningiomas. These meningioma sphere cells expressed various progenitor cell biomarkers and can undergo differentiation if appropriate stimuli are applied. Moreover, these meningioma stem-like cells are more resistant to irradiation treatment, and tumorigenic in in vivo xenograft models. These new findings could lead to a better understanding of the development and etiology of meningioma formation and suggest that meningioma stem-like cells may serve as a novel target in therapeutically resistant meningiomas.

Original languageEnglish (US)
Title of host publicationStem Cells and Cancer Stem Cells, Volume 10
Subtitle of host publicationTherapeutic Applications in Disease and Injury
PublisherSpringer Netherlands
Number of pages8
ISBN (Electronic)9789400762626
ISBN (Print)9789400762619
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Medicine(all)


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