Presence of coronary artery disease in diabetic and non diabetic South Asian immigrants

Sunita Dodani, Gyanendra Kumar Sharma

Research output: Contribution to journalArticle

Abstract

Introduction: South Asian Immigrants (SAIs) are the second fastest growing Asian immigrant population in the US, and at a higher risk of type 2 diabetes (diabetes) and coronary artery disease (CAD) than the general US population. Objectives: We sought to determine in SAIs the; 1) the prevalence of CAD risk factors in diabetics and non-diabetics; and b) the high possibility of CAD in diabetic SAIs. We also assessed the prevalence of sub-clinical CAD in both diabetics and non-diabetics SAIs using common carotid artery Intima-media thickness (CIMT) as a surrogate marker for atherosclerosis. Methods: In a cross-sectional study design, 213 first generation SAIs were recruited and based on the history, and fasting glucose levels were divided into two subgroups; 35 diabetics and 178 non-diabetics. 12-hour fasting blood samples were collected for glucose and total cholesterol levels. Exercise Tolerance Test (ETT) was performed to determine the possibility of CAD. Results: Both diabetics and non-diabetics SAIs in general, share a significant burden of CAD risk factors. The prevalence of hypertension (p = 0.003), total cholesterol ≥ 200 mg/dl (p < 0.0001) and family history of diabetes (p < 0.0001) was significantly was significantly higher in diabetics compared to non-diabetics. Of the 22/29 diabetic participants without known history of CAD, 45% had positive ETT (p < 0.001). Similarly, 63.1% of diabetics and 51.8 % of non-diabetics were positive for sub-clinical CAD using CIMT as a marker. Conclusion: The susceptibility to diabetes amongst SAIs promotes an adverse CAD risk, as evident by this small study. Further research, including larger longitudinal prospective studies, is required to validate the current small study findings with investigation of the temporal association.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalIndian Heart Journal
Volume70
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Coronary Artery Disease
Carotid Intima-Media Thickness
Exercise Tolerance
Exercise Test
Fasting
Cholesterol
Glucose
Common Carotid Artery
Carotid Arteries
Type 2 Diabetes Mellitus
Population
Longitudinal Studies
Atherosclerosis
Cross-Sectional Studies
Biomarkers
History
Prospective Studies
Hypertension
Research

Keywords

  • Carotid Intima Media Thickness
  • Coronary Artery Disease
  • Risk Factors
  • South Asian Immigrants
  • Type 2 Diabetes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Presence of coronary artery disease in diabetic and non diabetic South Asian immigrants. / Dodani, Sunita; Sharma, Gyanendra Kumar.

In: Indian Heart Journal, Vol. 70, No. 1, 01.01.2018, p. 50-55.

Research output: Contribution to journalArticle

@article{eea92bee78a8427cbc9aab3ff630a5a8,
title = "Presence of coronary artery disease in diabetic and non diabetic South Asian immigrants",
abstract = "Introduction: South Asian Immigrants (SAIs) are the second fastest growing Asian immigrant population in the US, and at a higher risk of type 2 diabetes (diabetes) and coronary artery disease (CAD) than the general US population. Objectives: We sought to determine in SAIs the; 1) the prevalence of CAD risk factors in diabetics and non-diabetics; and b) the high possibility of CAD in diabetic SAIs. We also assessed the prevalence of sub-clinical CAD in both diabetics and non-diabetics SAIs using common carotid artery Intima-media thickness (CIMT) as a surrogate marker for atherosclerosis. Methods: In a cross-sectional study design, 213 first generation SAIs were recruited and based on the history, and fasting glucose levels were divided into two subgroups; 35 diabetics and 178 non-diabetics. 12-hour fasting blood samples were collected for glucose and total cholesterol levels. Exercise Tolerance Test (ETT) was performed to determine the possibility of CAD. Results: Both diabetics and non-diabetics SAIs in general, share a significant burden of CAD risk factors. The prevalence of hypertension (p = 0.003), total cholesterol ≥ 200 mg/dl (p < 0.0001) and family history of diabetes (p < 0.0001) was significantly was significantly higher in diabetics compared to non-diabetics. Of the 22/29 diabetic participants without known history of CAD, 45{\%} had positive ETT (p < 0.001). Similarly, 63.1{\%} of diabetics and 51.8 {\%} of non-diabetics were positive for sub-clinical CAD using CIMT as a marker. Conclusion: The susceptibility to diabetes amongst SAIs promotes an adverse CAD risk, as evident by this small study. Further research, including larger longitudinal prospective studies, is required to validate the current small study findings with investigation of the temporal association.",
keywords = "Carotid Intima Media Thickness, Coronary Artery Disease, Risk Factors, South Asian Immigrants, Type 2 Diabetes",
author = "Sunita Dodani and Sharma, {Gyanendra Kumar}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.ihj.2017.07.009",
language = "English (US)",
volume = "70",
pages = "50--55",
journal = "Indian Heart Journal",
issn = "0019-4832",
publisher = "Cardiology Society of India",
number = "1",

}

TY - JOUR

T1 - Presence of coronary artery disease in diabetic and non diabetic South Asian immigrants

AU - Dodani, Sunita

AU - Sharma, Gyanendra Kumar

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: South Asian Immigrants (SAIs) are the second fastest growing Asian immigrant population in the US, and at a higher risk of type 2 diabetes (diabetes) and coronary artery disease (CAD) than the general US population. Objectives: We sought to determine in SAIs the; 1) the prevalence of CAD risk factors in diabetics and non-diabetics; and b) the high possibility of CAD in diabetic SAIs. We also assessed the prevalence of sub-clinical CAD in both diabetics and non-diabetics SAIs using common carotid artery Intima-media thickness (CIMT) as a surrogate marker for atherosclerosis. Methods: In a cross-sectional study design, 213 first generation SAIs were recruited and based on the history, and fasting glucose levels were divided into two subgroups; 35 diabetics and 178 non-diabetics. 12-hour fasting blood samples were collected for glucose and total cholesterol levels. Exercise Tolerance Test (ETT) was performed to determine the possibility of CAD. Results: Both diabetics and non-diabetics SAIs in general, share a significant burden of CAD risk factors. The prevalence of hypertension (p = 0.003), total cholesterol ≥ 200 mg/dl (p < 0.0001) and family history of diabetes (p < 0.0001) was significantly was significantly higher in diabetics compared to non-diabetics. Of the 22/29 diabetic participants without known history of CAD, 45% had positive ETT (p < 0.001). Similarly, 63.1% of diabetics and 51.8 % of non-diabetics were positive for sub-clinical CAD using CIMT as a marker. Conclusion: The susceptibility to diabetes amongst SAIs promotes an adverse CAD risk, as evident by this small study. Further research, including larger longitudinal prospective studies, is required to validate the current small study findings with investigation of the temporal association.

AB - Introduction: South Asian Immigrants (SAIs) are the second fastest growing Asian immigrant population in the US, and at a higher risk of type 2 diabetes (diabetes) and coronary artery disease (CAD) than the general US population. Objectives: We sought to determine in SAIs the; 1) the prevalence of CAD risk factors in diabetics and non-diabetics; and b) the high possibility of CAD in diabetic SAIs. We also assessed the prevalence of sub-clinical CAD in both diabetics and non-diabetics SAIs using common carotid artery Intima-media thickness (CIMT) as a surrogate marker for atherosclerosis. Methods: In a cross-sectional study design, 213 first generation SAIs were recruited and based on the history, and fasting glucose levels were divided into two subgroups; 35 diabetics and 178 non-diabetics. 12-hour fasting blood samples were collected for glucose and total cholesterol levels. Exercise Tolerance Test (ETT) was performed to determine the possibility of CAD. Results: Both diabetics and non-diabetics SAIs in general, share a significant burden of CAD risk factors. The prevalence of hypertension (p = 0.003), total cholesterol ≥ 200 mg/dl (p < 0.0001) and family history of diabetes (p < 0.0001) was significantly was significantly higher in diabetics compared to non-diabetics. Of the 22/29 diabetic participants without known history of CAD, 45% had positive ETT (p < 0.001). Similarly, 63.1% of diabetics and 51.8 % of non-diabetics were positive for sub-clinical CAD using CIMT as a marker. Conclusion: The susceptibility to diabetes amongst SAIs promotes an adverse CAD risk, as evident by this small study. Further research, including larger longitudinal prospective studies, is required to validate the current small study findings with investigation of the temporal association.

KW - Carotid Intima Media Thickness

KW - Coronary Artery Disease

KW - Risk Factors

KW - South Asian Immigrants

KW - Type 2 Diabetes

UR - http://www.scopus.com/inward/record.url?scp=85026545368&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026545368&partnerID=8YFLogxK

U2 - 10.1016/j.ihj.2017.07.009

DO - 10.1016/j.ihj.2017.07.009

M3 - Article

C2 - 29455788

AN - SCOPUS:85026545368

VL - 70

SP - 50

EP - 55

JO - Indian Heart Journal

JF - Indian Heart Journal

SN - 0019-4832

IS - 1

ER -