Presentation of an immunodominant T-cell epitope of hepatitis B surface antigen by the HLA-DPw4 molecule

E. Celis, R. W. Karr

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Human T cells that recognize a major epitope of the hepatitis B surface antigen were studied for their ability to react with antigen when presented by mouse fibroblasts that express class II products of the human major histocompatibility gene complex after gene transfection. L cells expressing HLA-DPw4, but not those expressing HLA-DR4 or HLA-DR7, induced strong proliferative responses of antigen-specific T cells to either hepatitis B surface antigen or the synthetic peptide S1d, which bears the immunodominant T-cell epitope. These results identified a genetic restriction element of human helper T-lymphocyte responses to a major antigenic determinant of hepatitis B virus and might be important in the design of subunit vaccines to this pathogen. Peptides that induce T-cell responses that are restricted by a frequently encountered major histocompatibility complex molecule in the general population such as DPw4 would be ideal candidates as subunit vaccines.

Original languageEnglish (US)
Pages (from-to)747-752
Number of pages6
JournalJournal of Virology
Volume63
Issue number2
StatePublished - Jan 1 1989

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Immunodominant Epitopes
T-Lymphocyte Epitopes
Hepatitis B Surface Antigens
epitopes
Subunit Vaccines
T-lymphocytes
Major Histocompatibility Complex
T-Lymphocytes
Epitopes
HLA-DR7 Antigen
HLA-DR4 Antigen
subunit vaccines
Peptide T
Antigens
Helper-Inducer T-Lymphocytes
Hepatitis B virus
Genes
Transfection
antigens
Fibroblasts

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Presentation of an immunodominant T-cell epitope of hepatitis B surface antigen by the HLA-DPw4 molecule. / Celis, E.; Karr, R. W.

In: Journal of Virology, Vol. 63, No. 2, 01.01.1989, p. 747-752.

Research output: Contribution to journalArticle

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