Prevalence and prediction of primary sleep disorders in a clinical trial of depressed patients with insomnia

William Vaughn McCall, James Kimball, Niki Boggs, Barbara Lasater, Ralph B. D'Agostino, Peter B. Rosenquist

Research output: Contribution to journalArticle

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Abstract

Insomnia-pharmacology clinical trials routinely exclude primary sleep disorders, such as obstructive sleep apnea (OSA) and periodic limb movement disorder (PLMD), with a single night of polysomnography (PSG). Given the expense of PSG, we examined whether a thorough clinical screening, combined with actigraphy, would successfully identify OSA and PLMD as part of baseline screening for a clinical trial of insomnia treatment in depressed patients. Of the 73 patients with a complete baseline dataset, 12 screened positive for OSA/PLMD (AHI > 15, or PLMAI > 15), while 61 "passed" the PSG screen. The OSA/PLMD+ patients were older (51.4 ± 10.2 y) and took more naps (2.6 per week) than the OSA/ PLMD-patients (41.3 ± 12.8 y; and 1.1 naps per week). The combination of age and nap frequency produced a "good" receiver operating characteristic (ROC) model for predicting OSA/PLMD+, with the area under the curve of 0.82. There were no other demographic, sleep diary, or actigraphic variables, which differed between OSA/PLM + or -, and no other variable improved the ROC model. Still, the best model misclassified 16 of 73 persons. We conclude that while age and the presence of napping were helpful in identifying OSA and PLM in a well-screened sample of depressed insomniacs, PSG is required to definitively identify and exclude primary sleep disorders in insomnia clinical trials.

Original languageEnglish (US)
Pages (from-to)454-458
Number of pages5
JournalJournal of Clinical Sleep Medicine
Volume5
Issue number5
StatePublished - Oct 15 2009

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Nocturnal Myoclonus Syndrome
Sleep Initiation and Maintenance Disorders
Obstructive Sleep Apnea
Clinical Trials
Polysomnography
ROC Curve
Actigraphy
Sleep Wake Disorders
Area Under Curve
Sleep
Demography
Pharmacology

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

Cite this

Prevalence and prediction of primary sleep disorders in a clinical trial of depressed patients with insomnia. / McCall, William Vaughn; Kimball, James; Boggs, Niki; Lasater, Barbara; D'Agostino, Ralph B.; Rosenquist, Peter B.

In: Journal of Clinical Sleep Medicine, Vol. 5, No. 5, 15.10.2009, p. 454-458.

Research output: Contribution to journalArticle

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