Prevalence of 3β-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with adrenal androgen excess

Carlos Moran, H. Downing Potter, Rosario Reyna, Larry R. Boots, Ricardo Azziz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

OBJECTIVE: We sought to determine the prevalence of 3β-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia among adult hyperandrogenic women with dehydroepiandrosterone sulfate excess. STUDY DESIGN: Thirty consecutive hyperandrogenic women with hirsutism, oligomenorrhea, or both and dehydroepiandrosterone sulfate levels of >8.5 μmol/L and 24 control subjects were studied. Basal sex hormone binding globulin, total and free testosterone, dehydroepiandrosterone sulfate, 17- hydroxyprogesterone, and basal and 60-minute corticotropin-stimulated 17- hydroxypregnenolone and dehydroepiandrosterone were measured, and the increment (change from basal to 60-minute value) was calculated. RESULTS: Twenty-six (87%) and 25 (83%) of the 30 hyperandrogenic patients studied had 60-minute dehydroepiandrosterone and change in 0- to 60-minute dehydroepiandrosterone levels greater than the mean + 2 SD of control subjects, respectively. Six (20%) and 6 (20%) of the 30 hyperandrogenic patients had 60-minute 17-hydroxypregnenolone and 0- to 60-minute change in 17-hydroxypregnenolone levels greater than the mean +2 SD of control subjects, respectively. However, none of the subjects had either 60-minute 17-hydroxypregnenolone levels or 60-minute dehydroepiandrosterone levels or both associated with the diagnosis of genetically proved 3β-hydroxysteroid dehydrogenase deficiency (>5-fold of the control mean value). CONCLUSION: 3β-Hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia is rare even among adult hyperandrogenic patients with adrenal androgen excess.

Original languageEnglish (US)
Pages (from-to)596-600
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume181
Issue number3
DOIs
StatePublished - Jan 1 1999

Fingerprint

3-Hydroxysteroid Dehydrogenases
17-alpha-Hydroxypregnenolone
Dehydroepiandrosterone
Dehydroepiandrosterone Sulfate
Androgens
Hyperplasia
Oligomenorrhea
17-alpha-Hydroxyprogesterone
Hirsutism
Sex Hormone-Binding Globulin
Adrenocorticotropic Hormone
Testosterone

Keywords

  • 3β-hydroxysteroid dehydrogenase
  • Adrenal hyperplasia
  • Hirsutism
  • Hyperandrogenism
  • Screening

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Prevalence of 3β-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with adrenal androgen excess. / Moran, Carlos; Potter, H. Downing; Reyna, Rosario; Boots, Larry R.; Azziz, Ricardo.

In: American Journal of Obstetrics and Gynecology, Vol. 181, No. 3, 01.01.1999, p. 596-600.

Research output: Contribution to journalArticle

Moran, Carlos ; Potter, H. Downing ; Reyna, Rosario ; Boots, Larry R. ; Azziz, Ricardo. / Prevalence of 3β-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with adrenal androgen excess. In: American Journal of Obstetrics and Gynecology. 1999 ; Vol. 181, No. 3. pp. 596-600.
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AU - Azziz, Ricardo

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AB - OBJECTIVE: We sought to determine the prevalence of 3β-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia among adult hyperandrogenic women with dehydroepiandrosterone sulfate excess. STUDY DESIGN: Thirty consecutive hyperandrogenic women with hirsutism, oligomenorrhea, or both and dehydroepiandrosterone sulfate levels of >8.5 μmol/L and 24 control subjects were studied. Basal sex hormone binding globulin, total and free testosterone, dehydroepiandrosterone sulfate, 17- hydroxyprogesterone, and basal and 60-minute corticotropin-stimulated 17- hydroxypregnenolone and dehydroepiandrosterone were measured, and the increment (change from basal to 60-minute value) was calculated. RESULTS: Twenty-six (87%) and 25 (83%) of the 30 hyperandrogenic patients studied had 60-minute dehydroepiandrosterone and change in 0- to 60-minute dehydroepiandrosterone levels greater than the mean + 2 SD of control subjects, respectively. Six (20%) and 6 (20%) of the 30 hyperandrogenic patients had 60-minute 17-hydroxypregnenolone and 0- to 60-minute change in 17-hydroxypregnenolone levels greater than the mean +2 SD of control subjects, respectively. However, none of the subjects had either 60-minute 17-hydroxypregnenolone levels or 60-minute dehydroepiandrosterone levels or both associated with the diagnosis of genetically proved 3β-hydroxysteroid dehydrogenase deficiency (>5-fold of the control mean value). CONCLUSION: 3β-Hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia is rare even among adult hyperandrogenic patients with adrenal androgen excess.

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