Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men

Stephen Goldstone, Joel M. Palefsky, Anna R. Giuliano, Edson D. Moreira, Carlos Aranda, Heiko Jessen, Richard J. Hillman, Daron Gale Ferris, Francois Coutlee, Kai Li Liaw, J. Brooke Marshall, Xuehong Zhang, Scott Vuocolo, Eliav Barr, Richard M. Haupt, Dalya Guris, Elizabeth I.O. Garner

Research output: Contribution to journalArticle

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Abstract

Background. We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human papillomavirus (HPV) infection in human immunodeficiency virus (HIV)-seronegative men who have sex with men (MSM). Methods. Data were analyzed from 602 MSM aged 16-27 years with ≤5 lifetime sexual partners. Serum samples were tested for antibodies to HPV6/11/16/18. Swab samples were collected separately from several anogenital areas for detection of HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59 DNA. Results. The prevalence of any tested HPV type was 18.5% at the penis, 17.1% at the scrotum, 33.0% at the perineal/ perianal region, 42.4% in the anal canal, and 48.0% at any site. Overall, 415 MSM (69.7%) were negative to HPV 6, 11, 16, and 18 at enrollment by both serology and DNA detection. Men residing in Europe and Latin America had significantly increased risk of HPV infection at external genital sites and the anal canal compared to men from Australia. Tobacco use and greater number of lifetime sexual partners was associated with higher HPV infection prevalence. Conclusions. The prevalence of HPV infection is high among young sexually active MSM, with the anal canal being the most common site of infection. Lifetime number of sexual partners was the most important modifiable risk factor for anogenital HPV infection.

Original languageEnglish (US)
Pages (from-to)66-74
Number of pages9
JournalJournal of Infectious Diseases
Volume203
Issue number1
DOIs
StatePublished - Jan 1 2011

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Papillomavirus Infections
HIV
Sexual Partners
Anal Canal
Human papillomavirus 11
Human papillomavirus 6
Scrotum
Latin America
DNA
Penis
Tobacco Use
Serology
Antibodies
Infection
Serum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Goldstone, S., Palefsky, J. M., Giuliano, A. R., Moreira, E. D., Aranda, C., Jessen, H., ... Garner, E. I. O. (2011). Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men. Journal of Infectious Diseases, 203(1), 66-74. https://doi.org/10.1093/infdis/jiq016

Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men. / Goldstone, Stephen; Palefsky, Joel M.; Giuliano, Anna R.; Moreira, Edson D.; Aranda, Carlos; Jessen, Heiko; Hillman, Richard J.; Ferris, Daron Gale; Coutlee, Francois; Liaw, Kai Li; Marshall, J. Brooke; Zhang, Xuehong; Vuocolo, Scott; Barr, Eliav; Haupt, Richard M.; Guris, Dalya; Garner, Elizabeth I.O.

In: Journal of Infectious Diseases, Vol. 203, No. 1, 01.01.2011, p. 66-74.

Research output: Contribution to journalArticle

Goldstone, S, Palefsky, JM, Giuliano, AR, Moreira, ED, Aranda, C, Jessen, H, Hillman, RJ, Ferris, DG, Coutlee, F, Liaw, KL, Marshall, JB, Zhang, X, Vuocolo, S, Barr, E, Haupt, RM, Guris, D & Garner, EIO 2011, 'Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men', Journal of Infectious Diseases, vol. 203, no. 1, pp. 66-74. https://doi.org/10.1093/infdis/jiq016
Goldstone, Stephen ; Palefsky, Joel M. ; Giuliano, Anna R. ; Moreira, Edson D. ; Aranda, Carlos ; Jessen, Heiko ; Hillman, Richard J. ; Ferris, Daron Gale ; Coutlee, Francois ; Liaw, Kai Li ; Marshall, J. Brooke ; Zhang, Xuehong ; Vuocolo, Scott ; Barr, Eliav ; Haupt, Richard M. ; Guris, Dalya ; Garner, Elizabeth I.O. / Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men. In: Journal of Infectious Diseases. 2011 ; Vol. 203, No. 1. pp. 66-74.
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abstract = "Background. We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human papillomavirus (HPV) infection in human immunodeficiency virus (HIV)-seronegative men who have sex with men (MSM). Methods. Data were analyzed from 602 MSM aged 16-27 years with ≤5 lifetime sexual partners. Serum samples were tested for antibodies to HPV6/11/16/18. Swab samples were collected separately from several anogenital areas for detection of HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59 DNA. Results. The prevalence of any tested HPV type was 18.5{\%} at the penis, 17.1{\%} at the scrotum, 33.0{\%} at the perineal/ perianal region, 42.4{\%} in the anal canal, and 48.0{\%} at any site. Overall, 415 MSM (69.7{\%}) were negative to HPV 6, 11, 16, and 18 at enrollment by both serology and DNA detection. Men residing in Europe and Latin America had significantly increased risk of HPV infection at external genital sites and the anal canal compared to men from Australia. Tobacco use and greater number of lifetime sexual partners was associated with higher HPV infection prevalence. Conclusions. The prevalence of HPV infection is high among young sexually active MSM, with the anal canal being the most common site of infection. Lifetime number of sexual partners was the most important modifiable risk factor for anogenital HPV infection.",
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AU - Moreira, Edson D.

AU - Aranda, Carlos

AU - Jessen, Heiko

AU - Hillman, Richard J.

AU - Ferris, Daron Gale

AU - Coutlee, Francois

AU - Liaw, Kai Li

AU - Marshall, J. Brooke

AU - Zhang, Xuehong

AU - Vuocolo, Scott

AU - Barr, Eliav

AU - Haupt, Richard M.

AU - Guris, Dalya

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N2 - Background. We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human papillomavirus (HPV) infection in human immunodeficiency virus (HIV)-seronegative men who have sex with men (MSM). Methods. Data were analyzed from 602 MSM aged 16-27 years with ≤5 lifetime sexual partners. Serum samples were tested for antibodies to HPV6/11/16/18. Swab samples were collected separately from several anogenital areas for detection of HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59 DNA. Results. The prevalence of any tested HPV type was 18.5% at the penis, 17.1% at the scrotum, 33.0% at the perineal/ perianal region, 42.4% in the anal canal, and 48.0% at any site. Overall, 415 MSM (69.7%) were negative to HPV 6, 11, 16, and 18 at enrollment by both serology and DNA detection. Men residing in Europe and Latin America had significantly increased risk of HPV infection at external genital sites and the anal canal compared to men from Australia. Tobacco use and greater number of lifetime sexual partners was associated with higher HPV infection prevalence. Conclusions. The prevalence of HPV infection is high among young sexually active MSM, with the anal canal being the most common site of infection. Lifetime number of sexual partners was the most important modifiable risk factor for anogenital HPV infection.

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