Prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux

James A. Koufman, Peter C. Belafsky, Kevin K. Bach, Elena Daniel, Gregory N Postma

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Objective: To report the prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux. Study Design: Prospective study of 58 consecutive patients with documented laryngopharyngeal reflux, all of whom underwent transnasal esophagoscopy as part of their reflux evaluations. Methods: All patients with a diagnosis of laryngopharyngeal reflux confirmed by abnormal pharyngeal pH monitoring over a 5-month period were included, and all subjects completed a self-administered reflux symptom index and underwent transnasal esophagoscopy with directed biopsy. Results: Of the 58 study patients with pH-documented laryngopharyngeal reflux, the mean age was 49 years (±13 y), and 53% (31 of 58) were women. Of the study group, 40% (23 of 58) had heartburn and 48% (28 of 58) had abnormal esophageal reflux (by pH monitoring criteria); by transnasal esophagoscopy with biopsy, 12% (7 of 58) had esophagitis and another 7% (4 of 58) had Barrett's metaplasia. Thus, 60% of the study cohort had no heartburn, and 81% (47 of 58) had normal esophageal epithelium (i.e., no esophagitis or Barrett's metaplasia). Conclusions: In the present series of patients with documented laryngopharyngeal reflux the prevalence of esophagitis and Barrett's metaplasia was only 19%. These data confirm the clinical impression that the patterns, mechanisms, and manifestations of laryngopharyngeal reflux differ from those of classic gastroesophageal reflux disease. Unlike gastroesophageal reflux disease, patients with laryngopharyngeal reflux uncommonly have esophagitis. Thus, although esophagoscopy may be an excellent method for screening the esophagus, it is not the method of choice for diagnosing laryngopharyngeal reflux.

Original languageEnglish (US)
Pages (from-to)1606-1609
Number of pages4
JournalLaryngoscope
Volume112
Issue number9
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Fingerprint

Laryngopharyngeal Reflux
Esophagitis
Esophagoscopy
Barrett Esophagus
Gastroesophageal Reflux
Heartburn
Esophageal pH Monitoring
Biopsy
Peptic Esophagitis
Esophagus
Cohort Studies
Epithelium
Prospective Studies

Keywords

  • Barrett's metaplasia
  • Esophagitis
  • Esophagoscopy
  • Gastroesophageal reflux
  • Gastroesophageal reflux disease
  • Laryngopharyngeal reflux

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux. / Koufman, James A.; Belafsky, Peter C.; Bach, Kevin K.; Daniel, Elena; Postma, Gregory N.

In: Laryngoscope, Vol. 112, No. 9, 01.01.2002, p. 1606-1609.

Research output: Contribution to journalArticle

Koufman, James A. ; Belafsky, Peter C. ; Bach, Kevin K. ; Daniel, Elena ; Postma, Gregory N. / Prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux. In: Laryngoscope. 2002 ; Vol. 112, No. 9. pp. 1606-1609.
@article{2825929d274945eb835a5d67d8963b0d,
title = "Prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux",
abstract = "Objective: To report the prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux. Study Design: Prospective study of 58 consecutive patients with documented laryngopharyngeal reflux, all of whom underwent transnasal esophagoscopy as part of their reflux evaluations. Methods: All patients with a diagnosis of laryngopharyngeal reflux confirmed by abnormal pharyngeal pH monitoring over a 5-month period were included, and all subjects completed a self-administered reflux symptom index and underwent transnasal esophagoscopy with directed biopsy. Results: Of the 58 study patients with pH-documented laryngopharyngeal reflux, the mean age was 49 years (±13 y), and 53{\%} (31 of 58) were women. Of the study group, 40{\%} (23 of 58) had heartburn and 48{\%} (28 of 58) had abnormal esophageal reflux (by pH monitoring criteria); by transnasal esophagoscopy with biopsy, 12{\%} (7 of 58) had esophagitis and another 7{\%} (4 of 58) had Barrett's metaplasia. Thus, 60{\%} of the study cohort had no heartburn, and 81{\%} (47 of 58) had normal esophageal epithelium (i.e., no esophagitis or Barrett's metaplasia). Conclusions: In the present series of patients with documented laryngopharyngeal reflux the prevalence of esophagitis and Barrett's metaplasia was only 19{\%}. These data confirm the clinical impression that the patterns, mechanisms, and manifestations of laryngopharyngeal reflux differ from those of classic gastroesophageal reflux disease. Unlike gastroesophageal reflux disease, patients with laryngopharyngeal reflux uncommonly have esophagitis. Thus, although esophagoscopy may be an excellent method for screening the esophagus, it is not the method of choice for diagnosing laryngopharyngeal reflux.",
keywords = "Barrett's metaplasia, Esophagitis, Esophagoscopy, Gastroesophageal reflux, Gastroesophageal reflux disease, Laryngopharyngeal reflux",
author = "Koufman, {James A.} and Belafsky, {Peter C.} and Bach, {Kevin K.} and Elena Daniel and Postma, {Gregory N}",
year = "2002",
month = "1",
day = "1",
doi = "10.1097/00005537-200209000-00014",
language = "English (US)",
volume = "112",
pages = "1606--1609",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux

AU - Koufman, James A.

AU - Belafsky, Peter C.

AU - Bach, Kevin K.

AU - Daniel, Elena

AU - Postma, Gregory N

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Objective: To report the prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux. Study Design: Prospective study of 58 consecutive patients with documented laryngopharyngeal reflux, all of whom underwent transnasal esophagoscopy as part of their reflux evaluations. Methods: All patients with a diagnosis of laryngopharyngeal reflux confirmed by abnormal pharyngeal pH monitoring over a 5-month period were included, and all subjects completed a self-administered reflux symptom index and underwent transnasal esophagoscopy with directed biopsy. Results: Of the 58 study patients with pH-documented laryngopharyngeal reflux, the mean age was 49 years (±13 y), and 53% (31 of 58) were women. Of the study group, 40% (23 of 58) had heartburn and 48% (28 of 58) had abnormal esophageal reflux (by pH monitoring criteria); by transnasal esophagoscopy with biopsy, 12% (7 of 58) had esophagitis and another 7% (4 of 58) had Barrett's metaplasia. Thus, 60% of the study cohort had no heartburn, and 81% (47 of 58) had normal esophageal epithelium (i.e., no esophagitis or Barrett's metaplasia). Conclusions: In the present series of patients with documented laryngopharyngeal reflux the prevalence of esophagitis and Barrett's metaplasia was only 19%. These data confirm the clinical impression that the patterns, mechanisms, and manifestations of laryngopharyngeal reflux differ from those of classic gastroesophageal reflux disease. Unlike gastroesophageal reflux disease, patients with laryngopharyngeal reflux uncommonly have esophagitis. Thus, although esophagoscopy may be an excellent method for screening the esophagus, it is not the method of choice for diagnosing laryngopharyngeal reflux.

AB - Objective: To report the prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux. Study Design: Prospective study of 58 consecutive patients with documented laryngopharyngeal reflux, all of whom underwent transnasal esophagoscopy as part of their reflux evaluations. Methods: All patients with a diagnosis of laryngopharyngeal reflux confirmed by abnormal pharyngeal pH monitoring over a 5-month period were included, and all subjects completed a self-administered reflux symptom index and underwent transnasal esophagoscopy with directed biopsy. Results: Of the 58 study patients with pH-documented laryngopharyngeal reflux, the mean age was 49 years (±13 y), and 53% (31 of 58) were women. Of the study group, 40% (23 of 58) had heartburn and 48% (28 of 58) had abnormal esophageal reflux (by pH monitoring criteria); by transnasal esophagoscopy with biopsy, 12% (7 of 58) had esophagitis and another 7% (4 of 58) had Barrett's metaplasia. Thus, 60% of the study cohort had no heartburn, and 81% (47 of 58) had normal esophageal epithelium (i.e., no esophagitis or Barrett's metaplasia). Conclusions: In the present series of patients with documented laryngopharyngeal reflux the prevalence of esophagitis and Barrett's metaplasia was only 19%. These data confirm the clinical impression that the patterns, mechanisms, and manifestations of laryngopharyngeal reflux differ from those of classic gastroesophageal reflux disease. Unlike gastroesophageal reflux disease, patients with laryngopharyngeal reflux uncommonly have esophagitis. Thus, although esophagoscopy may be an excellent method for screening the esophagus, it is not the method of choice for diagnosing laryngopharyngeal reflux.

KW - Barrett's metaplasia

KW - Esophagitis

KW - Esophagoscopy

KW - Gastroesophageal reflux

KW - Gastroesophageal reflux disease

KW - Laryngopharyngeal reflux

UR - http://www.scopus.com/inward/record.url?scp=0036725589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036725589&partnerID=8YFLogxK

U2 - 10.1097/00005537-200209000-00014

DO - 10.1097/00005537-200209000-00014

M3 - Article

VL - 112

SP - 1606

EP - 1609

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 9

ER -