Prevalence of hyperandrogenemia among nonhirsute oligo-ovulatory women

Stephen E. Allen, H. Downing Potter, Ricardo Azziz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To test the hypothesis that oligo-ovulatory ovulation is associated with hyperandrogenemia in the absence of other clinical signs of androgen excess. Design: Retrospective cohort controlled. Setting: Tertiary care university-based outpatient clinic. Patient(s): Thirty-two consecutive nonhirsute oligo-ovulatory women and 37 healthy eumenorrheic controls. Intervention(s): All study subjects underwent a physical exam and blood sampling in the follicular phase of the menstrual cycle. Main Outcome Measure(s): Serum was assayed for total T, sex hormone-binding globulin (SHBG), androstenedione (A), and DS, and the free T level was calculated. Result(s): Mean free T was higher and SHBG was lower in oligo-ovulatory patients compared with controls. The oligo-ovulatory patients were subdivided according to severity of menstrual abnormalities into those with cycles < 45 days (n = 19, oligo-ovulatory-short) and ≤45 days (n = 13, oligo-ovulatory- long). Oligo-ovulatory-long and -short patients had similar mean DS, A, and total T levels; but mean free T was higher and SHBG was lower in oligo- ovulatory-long patients compared with either oligo-ovulatory-short women or controls. Five of 13 (38%) oligo-ovulatory-long patients had at least one abnormal androgen value compared with 1 of 19 (5%) oligo-ovulatory-short patients, which was a significant difference. Conclusion(s): Approximately 40% of nonhirsute oligo-ovulatory women with cycle intervals ≤ 45 days demonstrate at least one abnormally elevated androgen level, suggesting that they may have a discrete form of the polycystic ovary syndrome. Furthermore, this data brings into question the sensitivity of hirsutism as a marker for hyperandrogenemia.

Original languageEnglish (US)
Pages (from-to)569-572
Number of pages4
JournalFertility and sterility
Volume67
Issue number3
DOIs
StatePublished - Jan 1 1997

Fingerprint

Sex Hormone-Binding Globulin
Androgens
Hirsutism
Follicular Phase
Androstenedione
Polycystic Ovary Syndrome
Tertiary Healthcare
Ambulatory Care Facilities
Ovulation
Outcome Assessment (Health Care)
Serum

Keywords

  • Androgens
  • hirsutism
  • ovulatory dysfunction

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Prevalence of hyperandrogenemia among nonhirsute oligo-ovulatory women. / Allen, Stephen E.; Potter, H. Downing; Azziz, Ricardo.

In: Fertility and sterility, Vol. 67, No. 3, 01.01.1997, p. 569-572.

Research output: Contribution to journalArticle

Allen, Stephen E. ; Potter, H. Downing ; Azziz, Ricardo. / Prevalence of hyperandrogenemia among nonhirsute oligo-ovulatory women. In: Fertility and sterility. 1997 ; Vol. 67, No. 3. pp. 569-572.
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abstract = "Objective: To test the hypothesis that oligo-ovulatory ovulation is associated with hyperandrogenemia in the absence of other clinical signs of androgen excess. Design: Retrospective cohort controlled. Setting: Tertiary care university-based outpatient clinic. Patient(s): Thirty-two consecutive nonhirsute oligo-ovulatory women and 37 healthy eumenorrheic controls. Intervention(s): All study subjects underwent a physical exam and blood sampling in the follicular phase of the menstrual cycle. Main Outcome Measure(s): Serum was assayed for total T, sex hormone-binding globulin (SHBG), androstenedione (A), and DS, and the free T level was calculated. Result(s): Mean free T was higher and SHBG was lower in oligo-ovulatory patients compared with controls. The oligo-ovulatory patients were subdivided according to severity of menstrual abnormalities into those with cycles < 45 days (n = 19, oligo-ovulatory-short) and ≤45 days (n = 13, oligo-ovulatory- long). Oligo-ovulatory-long and -short patients had similar mean DS, A, and total T levels; but mean free T was higher and SHBG was lower in oligo- ovulatory-long patients compared with either oligo-ovulatory-short women or controls. Five of 13 (38{\%}) oligo-ovulatory-long patients had at least one abnormal androgen value compared with 1 of 19 (5{\%}) oligo-ovulatory-short patients, which was a significant difference. Conclusion(s): Approximately 40{\%} of nonhirsute oligo-ovulatory women with cycle intervals ≤ 45 days demonstrate at least one abnormally elevated androgen level, suggesting that they may have a discrete form of the polycystic ovary syndrome. Furthermore, this data brings into question the sensitivity of hirsutism as a marker for hyperandrogenemia.",
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