Prevalence of hyperandrogenemia in the polycystic ovary syndrome diagnosed by the National Institutes of Health 1990 criteria

Andy Huang, Kathleen Brennan, Ricardo Azziz

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Objective: To determine the prevalence of elevated total and free T, and DHEAS, alone and in combination, in patients with polycystic ovary syndrome (PCOS). Design: Cross-sectional analysis. Setting: Tertiary care academic medical center. Patient(s): Seven hundred twenty patients diagnosed with PCOS according to the National Institutes of Health 1990 criteria. Intervention(s): History, physical examination, and blood sampling. Main Outcome Measure(s): Hyperandrogenemia, defined as at least one androgen value above the 95th percentile of 98 healthy control women (i.e., total T >88 ng/dL, free T >0.75 ng/dL, and DHEAS >2,750 ng/mL). Result(s): A total of 716 subjects with PCOS were included. The overall prevalence of hyperandrogenemia in PCOS was 75.3%. Supranormal levels of free T were present in 57.6%, of total T in 33.0%, and of DHEAS in 32.7% of patients with PCOS. When assessing the prevalence of two abnormal values, the prevalence of simultaneously elevated androgens was lowest with total T and DHEAS (1.7%) and highest with total T and free T (20.4%). Altogether, simultaneous elevations in all three markers were found in 8.7% of subjects with PCOS. Conclusion(s): Approximately three-fourths of patients with PCOS diagnosed by the National Institutes of Health 1990 criteria have evidence of hyperandrogenemia; the single most predictive assay was the measurement of free T with ∼60% of patients demonstrating supranormal levels.

Original languageEnglish (US)
Pages (from-to)1938-1941
Number of pages4
JournalFertility and sterility
Volume93
Issue number6
DOIs
StatePublished - Apr 1 2010

Fingerprint

Polycystic Ovary Syndrome
National Institutes of Health (U.S.)
Androgens
Tertiary Healthcare
Physical Examination
Cross-Sectional Studies
History
Outcome Assessment (Health Care)

Keywords

  • Polycystic ovary syndrome
  • dehydroepiandrosterone sulfate
  • free testosterone
  • hyperandrogenemia
  • total testosterone

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Prevalence of hyperandrogenemia in the polycystic ovary syndrome diagnosed by the National Institutes of Health 1990 criteria. / Huang, Andy; Brennan, Kathleen; Azziz, Ricardo.

In: Fertility and sterility, Vol. 93, No. 6, 01.04.2010, p. 1938-1941.

Research output: Contribution to journalArticle

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abstract = "Objective: To determine the prevalence of elevated total and free T, and DHEAS, alone and in combination, in patients with polycystic ovary syndrome (PCOS). Design: Cross-sectional analysis. Setting: Tertiary care academic medical center. Patient(s): Seven hundred twenty patients diagnosed with PCOS according to the National Institutes of Health 1990 criteria. Intervention(s): History, physical examination, and blood sampling. Main Outcome Measure(s): Hyperandrogenemia, defined as at least one androgen value above the 95th percentile of 98 healthy control women (i.e., total T >88 ng/dL, free T >0.75 ng/dL, and DHEAS >2,750 ng/mL). Result(s): A total of 716 subjects with PCOS were included. The overall prevalence of hyperandrogenemia in PCOS was 75.3{\%}. Supranormal levels of free T were present in 57.6{\%}, of total T in 33.0{\%}, and of DHEAS in 32.7{\%} of patients with PCOS. When assessing the prevalence of two abnormal values, the prevalence of simultaneously elevated androgens was lowest with total T and DHEAS (1.7{\%}) and highest with total T and free T (20.4{\%}). Altogether, simultaneous elevations in all three markers were found in 8.7{\%} of subjects with PCOS. Conclusion(s): Approximately three-fourths of patients with PCOS diagnosed by the National Institutes of Health 1990 criteria have evidence of hyperandrogenemia; the single most predictive assay was the measurement of free T with ∼60{\%} of patients demonstrating supranormal levels.",
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