Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes

J. Yang, Lernmark, U. M. Uusitalo, K. F. Lynch, R. Veijola, C. Winkler, H. E. Larsson, M. Rewers, J. X. She, A. G. Ziegler, O. G. Simell, W. A. Hagopian, B. Akolkar, J. P. Krischer, K. Vehik

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.Methods:Repeated measures of weight and height were collected from 5969 children 2-4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index (BMI) of 25 and 30 kg m-2 at age 18.Results:The average BMI was comparable across specific HLA genotypes at every age point. The proportion of overweight was not different by HLA, but percent obesity varied by age with a decreasing trend among DQ2/8 carriers (P for trend=0.0315). A multivariable regression model suggested DQ2/2 was associated with higher obesity risk at age 4 (odds ratio, 2.41; 95% confidence interval, 1.21-4.80) after adjusting for the development of islet autoantibody and/or type 1 diabetes.Conclusions:The HLA-DQ2/2 genotype may predispose to obesity among 2-4-year-old children with genetic risk for type 1 diabetes.

Original languageEnglish (US)
Pages (from-to)1491-1496
Number of pages6
JournalInternational Journal of Obesity
Volume38
Issue number12
DOIs
StatePublished - Dec 11 2014

Fingerprint

HLA Antigens
Type 1 Diabetes Mellitus
Obesity
Genotype
Body Size
Body Mass Index
Advisory Committees
Autoimmunity
Autoantibodies
Odds Ratio
Prospective Studies
Confidence Intervals
Weights and Measures

Keywords

  • HLA genotype
  • autoantibodies
  • body mass index
  • pediatric
  • type 1 diabetes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Yang, J., Lernmark, Uusitalo, U. M., Lynch, K. F., Veijola, R., Winkler, C., ... Vehik, K. (2014). Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes. International Journal of Obesity, 38(12), 1491-1496. https://doi.org/10.1038/ijo.2014.55

Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes. / Yang, J.; Lernmark; Uusitalo, U. M.; Lynch, K. F.; Veijola, R.; Winkler, C.; Larsson, H. E.; Rewers, M.; She, J. X.; Ziegler, A. G.; Simell, O. G.; Hagopian, W. A.; Akolkar, B.; Krischer, J. P.; Vehik, K.

In: International Journal of Obesity, Vol. 38, No. 12, 11.12.2014, p. 1491-1496.

Research output: Contribution to journalArticle

Yang, J, Lernmark, Uusitalo, UM, Lynch, KF, Veijola, R, Winkler, C, Larsson, HE, Rewers, M, She, JX, Ziegler, AG, Simell, OG, Hagopian, WA, Akolkar, B, Krischer, JP & Vehik, K 2014, 'Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes', International Journal of Obesity, vol. 38, no. 12, pp. 1491-1496. https://doi.org/10.1038/ijo.2014.55
Yang, J. ; Lernmark ; Uusitalo, U. M. ; Lynch, K. F. ; Veijola, R. ; Winkler, C. ; Larsson, H. E. ; Rewers, M. ; She, J. X. ; Ziegler, A. G. ; Simell, O. G. ; Hagopian, W. A. ; Akolkar, B. ; Krischer, J. P. ; Vehik, K. / Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes. In: International Journal of Obesity. 2014 ; Vol. 38, No. 12. pp. 1491-1496.
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abstract = "Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.Methods:Repeated measures of weight and height were collected from 5969 children 2-4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index (BMI) of 25 and 30 kg m-2 at age 18.Results:The average BMI was comparable across specific HLA genotypes at every age point. The proportion of overweight was not different by HLA, but percent obesity varied by age with a decreasing trend among DQ2/8 carriers (P for trend=0.0315). A multivariable regression model suggested DQ2/2 was associated with higher obesity risk at age 4 (odds ratio, 2.41; 95{\%} confidence interval, 1.21-4.80) after adjusting for the development of islet autoantibody and/or type 1 diabetes.Conclusions:The HLA-DQ2/2 genotype may predispose to obesity among 2-4-year-old children with genetic risk for type 1 diabetes.",
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AU - Lernmark,

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AU - Lynch, K. F.

AU - Veijola, R.

AU - Winkler, C.

AU - Larsson, H. E.

AU - Rewers, M.

AU - She, J. X.

AU - Ziegler, A. G.

AU - Simell, O. G.

AU - Hagopian, W. A.

AU - Akolkar, B.

AU - Krischer, J. P.

AU - Vehik, K.

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N2 - Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.Methods:Repeated measures of weight and height were collected from 5969 children 2-4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index (BMI) of 25 and 30 kg m-2 at age 18.Results:The average BMI was comparable across specific HLA genotypes at every age point. The proportion of overweight was not different by HLA, but percent obesity varied by age with a decreasing trend among DQ2/8 carriers (P for trend=0.0315). A multivariable regression model suggested DQ2/2 was associated with higher obesity risk at age 4 (odds ratio, 2.41; 95% confidence interval, 1.21-4.80) after adjusting for the development of islet autoantibody and/or type 1 diabetes.Conclusions:The HLA-DQ2/2 genotype may predispose to obesity among 2-4-year-old children with genetic risk for type 1 diabetes.

AB - Objectives:Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.Methods:Repeated measures of weight and height were collected from 5969 children 2-4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index (BMI) of 25 and 30 kg m-2 at age 18.Results:The average BMI was comparable across specific HLA genotypes at every age point. The proportion of overweight was not different by HLA, but percent obesity varied by age with a decreasing trend among DQ2/8 carriers (P for trend=0.0315). A multivariable regression model suggested DQ2/2 was associated with higher obesity risk at age 4 (odds ratio, 2.41; 95% confidence interval, 1.21-4.80) after adjusting for the development of islet autoantibody and/or type 1 diabetes.Conclusions:The HLA-DQ2/2 genotype may predispose to obesity among 2-4-year-old children with genetic risk for type 1 diabetes.

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