Preventing bone loss and weight gain with combinations of vitamin d and phytochemicals

Ching Yi Lai, Jeong Yeh Yang, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Richard D. Lewis, Mark W Hamrick, Diane L. Hartzell, Clifton A. Baile

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Vitamin D and certain natural compounds have been shown to regulate both lipid metabolism and bone formation. Treatments that prevent or reverse age-related increase in bone marrow adiposity could both increase new bone formation and inhibit bone destruction. We tested the hypothesis that dietary supplementation with combinations of vitamin D and phytochemicals inhibits bone loss and decreases adiposity to a greater extent than control or vitamin D-alone diets. Aged ovariectomized female rats (12 months old, n=50, initial body weight=240g) were given control (AIN-93M diet), vitamin D (2,400IU/kg), or vitamin D plus resveratrol (16, 80, or 400mg/kg of diet [low, medium, and high dose, respectively]), quercetin (80, 400, or 2,000mg/kg of diet), and genistein (64, 256, or 1,040mg/kg of diet) for 8 weeks. The high-dose treatment (vitamin D+400mg/kg resveratrol+2,000mg/kg quercetin+1,040mg/kg genistein) reduced body weight gain (P<.05) and the fat pad weights (P<.05). This treatment also increased the serum concentration of insulin-like growth factor-1 (P<.05) and the bone mineral content of the femur. Micro-computed tomography and histomorphometric analyses indicated that the high-dose treatment prevented loss of trabecular bone (P<.05) and reduced marrow adipocytes (P<.001) and osteoclasts (P<.05) compared with the control and vitamin D alone (P<.05). We conclude that aged ovariectomized female rats supplemented with vitamin D combined with genistein, quercetin, and resveratrol had improved bone mineral density and reduced body weight gain and a significant decrease in bone marrow adipocytes. The synergistic effects of a combination of phytochemicals with vitamin D may be effective in reducing bone loss and weight gain after menopause.

Original languageEnglish (US)
Pages (from-to)1352-1362
Number of pages11
JournalJournal of Medicinal Food
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2011

Fingerprint

Phytochemicals
Vitamin D
Vitamins
Weight Gain
Bone and Bones
Genistein
Diet
Quercetin
Bone Marrow
Body Weight
Adiposity
Adipocytes
Osteogenesis
Bone Density
Ergocalciferols
Somatomedins
Osteoclasts
Menopause
Dietary Supplements
Lipid Metabolism

Keywords

  • bone loss
  • genistein
  • osteoporosis
  • ovariectomized rats
  • quercetin
  • resveratrol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Lai, C. Y., Yang, J. Y., Rayalam, S., Della-Fera, M. A., Ambati, S., Lewis, R. D., ... Baile, C. A. (2011). Preventing bone loss and weight gain with combinations of vitamin d and phytochemicals. Journal of Medicinal Food, 14(11), 1352-1362. https://doi.org/10.1089/jmf.2010.0232

Preventing bone loss and weight gain with combinations of vitamin d and phytochemicals. / Lai, Ching Yi; Yang, Jeong Yeh; Rayalam, Srujana; Della-Fera, Mary Anne; Ambati, Suresh; Lewis, Richard D.; Hamrick, Mark W; Hartzell, Diane L.; Baile, Clifton A.

In: Journal of Medicinal Food, Vol. 14, No. 11, 01.11.2011, p. 1352-1362.

Research output: Contribution to journalArticle

Lai, CY, Yang, JY, Rayalam, S, Della-Fera, MA, Ambati, S, Lewis, RD, Hamrick, MW, Hartzell, DL & Baile, CA 2011, 'Preventing bone loss and weight gain with combinations of vitamin d and phytochemicals', Journal of Medicinal Food, vol. 14, no. 11, pp. 1352-1362. https://doi.org/10.1089/jmf.2010.0232
Lai CY, Yang JY, Rayalam S, Della-Fera MA, Ambati S, Lewis RD et al. Preventing bone loss and weight gain with combinations of vitamin d and phytochemicals. Journal of Medicinal Food. 2011 Nov 1;14(11):1352-1362. https://doi.org/10.1089/jmf.2010.0232
Lai, Ching Yi ; Yang, Jeong Yeh ; Rayalam, Srujana ; Della-Fera, Mary Anne ; Ambati, Suresh ; Lewis, Richard D. ; Hamrick, Mark W ; Hartzell, Diane L. ; Baile, Clifton A. / Preventing bone loss and weight gain with combinations of vitamin d and phytochemicals. In: Journal of Medicinal Food. 2011 ; Vol. 14, No. 11. pp. 1352-1362.
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