Prevention of adhesions to polypropylene mesh in a rabbit model

Robert Charles Dinsmore, William C. Calton

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The purpose of this study was to develop a quantitative model for evaluating adhesion formation and to determine whether Seprafilm (HAL-F) bioresorbable membrane (Genzyme Corp., Cambridge, MA) is effective in preventing adhesions to polypropylene mesh (PPM). PPM has been shown to be an effective material for the repair of abdominal wall defects. One disadvantage of PPM is its tendency to form dense adhesions when in contact with abdominal viscera. HAL-F, a sodium hyaluronate/carboxymethylcellulose absorbable membrane, has been shown to prevent adhesion formation after midline closures. Its efficacy in preventing adhesions to PPM has not been examined previously. A 5 x 7-cm anterior abdominal wall defect was created in 24 New Zealand White rabbits. This defect was then repaired with PPM. In the experimental group, a 5 x 7-cm piece of HAL-F was placed between the mesh and the abdominal viscera. At 30 days, the animals were killed and adhesions were categorized and quantified using digital image analysis of inked specimens. The strength of mesh incorporation into surrounding tissues was also examined using an Instron tensiometer. The formation of adhesions between the viscera and mesh repair was significantly reduced by the use of HAL-F. The surface area involved for bowel adhesions was reduced 94 per cent (P = 0.00132). The strength of incorporation was not adversely affected. HAL-F is highly effective in preventing adhesions to PPM, without adversely effecting the strength of mesh incorporation.

Original languageEnglish (US)
Pages (from-to)383-387
Number of pages5
JournalAmerican Surgeon
Volume65
Issue number4
StatePublished - Jan 1 1999

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Polypropylenes
Rabbits
Viscera
Abdominal Wall
Carboxymethylcellulose Sodium
Membranes
Hyaluronic Acid

ASJC Scopus subject areas

  • Surgery

Cite this

Dinsmore, R. C., & Calton, W. C. (1999). Prevention of adhesions to polypropylene mesh in a rabbit model. American Surgeon, 65(4), 383-387.

Prevention of adhesions to polypropylene mesh in a rabbit model. / Dinsmore, Robert Charles; Calton, William C.

In: American Surgeon, Vol. 65, No. 4, 01.01.1999, p. 383-387.

Research output: Contribution to journalArticle

Dinsmore, RC & Calton, WC 1999, 'Prevention of adhesions to polypropylene mesh in a rabbit model', American Surgeon, vol. 65, no. 4, pp. 383-387.
Dinsmore RC, Calton WC. Prevention of adhesions to polypropylene mesh in a rabbit model. American Surgeon. 1999 Jan 1;65(4):383-387.
Dinsmore, Robert Charles ; Calton, William C. / Prevention of adhesions to polypropylene mesh in a rabbit model. In: American Surgeon. 1999 ; Vol. 65, No. 4. pp. 383-387.
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