TY - JOUR
T1 - Prevention of cognitive impairments and neurodegeneration by Khamira Abresham Hakim Arshad Wala
AU - Khan, M. Badruzzaman
AU - Hoda, Md Nasrul
AU - Yousuf, Seema
AU - Ishrat, Tauheed
AU - Ahmad, Muzamil
AU - Ahmad, Abdullah Shafique
AU - Alavi, Shareef Haider
AU - Haque, Niloufar
AU - Islam, Fakhrul
N1 - Funding Information:
Authors are thankful to the Department of Ayurveda, Yoga and Naturopathy, Unani, Sidha and Homeopath (AYUSH), Ministry of Health and Family Welfare, Government of India, New Delhi, for financial assistance. We are highly thankful to Ms. Shaukat Shah in-charge of animal house, and technical assistance of Mr. Dharamvir Singh and Mr. Anil Kumar of Neurotoxicology Lab, Jamia Hamdard (Hamdard University) New Delhi, for help and cooperation.
PY - 2006/11/3
Y1 - 2006/11/3
N2 - Khamira Abresham Hakim Arshad Wala (KAHAW) is an effective and potent cardiac tonic with well-known antioxidant properties. The extensive use of this preparation in Indian system of Unani medicine led us to hypothesize that the pretreatment of this drug to male Wistar rats would prevent cognitive and neurobehavioral impairments. The cognitive impairment was developed by giving single intracerebroventricular injection of 1.5 mg/kg body weight of streptozotocin (STZ) bilaterally. An increased latency and path length was observed in cognitive, i.e. STZ group as compared to sham group and these were restored significantly in STZ group pretreated with KAHAW (700 mg/kg body weight for 15 days). The activity of antioxidant enzymes, viz. glutathione reductase, glutathione S-transferase, glutathione peroxidase, and superoxide dismutase was decreased in STZ group as compared to sham group and pretreatment of STZ group with KAHAW has protected their activities significantly. Moreover, the significantly depleted content of reduced glutathione and significantly elevated level of thiobarbituric acid reactive substances (TBARS) in STZ group were protected significantly with KAHAW. The study concludes that the therapeutic intervention of KAHAW may be used to prevent or to decrease the deterioration of cognitive function and neurobehavioral activities, often associated with the generation of free radicals.
AB - Khamira Abresham Hakim Arshad Wala (KAHAW) is an effective and potent cardiac tonic with well-known antioxidant properties. The extensive use of this preparation in Indian system of Unani medicine led us to hypothesize that the pretreatment of this drug to male Wistar rats would prevent cognitive and neurobehavioral impairments. The cognitive impairment was developed by giving single intracerebroventricular injection of 1.5 mg/kg body weight of streptozotocin (STZ) bilaterally. An increased latency and path length was observed in cognitive, i.e. STZ group as compared to sham group and these were restored significantly in STZ group pretreated with KAHAW (700 mg/kg body weight for 15 days). The activity of antioxidant enzymes, viz. glutathione reductase, glutathione S-transferase, glutathione peroxidase, and superoxide dismutase was decreased in STZ group as compared to sham group and pretreatment of STZ group with KAHAW has protected their activities significantly. Moreover, the significantly depleted content of reduced glutathione and significantly elevated level of thiobarbituric acid reactive substances (TBARS) in STZ group were protected significantly with KAHAW. The study concludes that the therapeutic intervention of KAHAW may be used to prevent or to decrease the deterioration of cognitive function and neurobehavioral activities, often associated with the generation of free radicals.
KW - Antioxidant enzymes
KW - Cognitive impairments
KW - Neurobehavioral activity
KW - Oxidative stress
KW - Unani medicine
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U2 - 10.1016/j.jep.2006.04.012
DO - 10.1016/j.jep.2006.04.012
M3 - Article
C2 - 16765546
AN - SCOPUS:33749325518
SN - 0378-8741
VL - 108
SP - 68
EP - 73
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 1
ER -