Primary cilia are mechanosensory organelles with chemosensory roles

Brian S. Muntean, Xingjian Jin, Surya M. Nauli

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

In the previous volume, we discussed the roles of primary cilia as mechanosensory organelles. Primary cilia have also been proposed to be chemosensory organelles. As a mechanosensory organelle, primary cilium could initiate the release of various cytokines-like substances, involving nitric oxide and purinergic agonists. As a chemosensory organelle, primary cilium also contains various receptors responding to hedgehog and Wnt signaling systems. In this section, we will describe cilia as newly recognized communication devices in response to agonist to regulate cell cycle and cellular development.

Original languageEnglish (US)
Title of host publicationMechanical Stretch and Cytokines
PublisherSpringer Netherlands
Pages201-222
Number of pages22
ISBN (Electronic)9789400720046
ISBN (Print)9789400720039
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Keywords

  • Basal body
  • Centriole
  • Centrosome
  • Primary cilium
  • Shear stress
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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