Primary intracranial germ cell tumors: Clinicopathologic review of 32 cases

K. L. Salzman, A. M. Rojiani, J. Buatti, R. G. Quisling, R. B. Marcus, B. L. Maria, J. P. Mickle, A. Kedar

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Primary intracranial germ cell neoplasms are rare tumors and constitute a heterogenous group. We have reviewed 32 cases, over a 21-year period, from the University of Florida. The cases include 22 germinomas, 6 mixed germ cell tumors, and 4 teratomas. The clinical presentations in these cases were more closely related to the location of the tumor, that is, pineal or suprasellar, rather than the histologic subtype. Neuroimaging evaluations was useful in distinguishing between germinomas, teratomas, and other mixed germ cell tumors (MGCTs), primarily by evaluation of cystic versus solid lesions (teratoma versus germinoma), contents of cysts (teratoma versus MGCT), and infiltrative nature of the tumors (MGCT), although cytologic-histopathologic confirmation remains necessary. Germinomas responded favorably to radiation therapy with survival periods of over 16 years; MGCTs were treated with combination chemotherapy and radiation, with a markedly poorer prognosis. This study underlines the critical significance of histopathologic evaluation of the tumor in determining therapeutic interventions as well as prognosis.

Original languageEnglish (US)
Pages (from-to)713-727
Number of pages15
JournalPediatric Pathology and Laboratory Medicine
Volume17
Issue number5
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • Clinical features
  • Follow-up
  • Germ cell tumors
  • Intracranial
  • Neuroimaging
  • Pathology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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  • Cite this

    Salzman, K. L., Rojiani, A. M., Buatti, J., Quisling, R. G., Marcus, R. B., Maria, B. L., Mickle, J. P., & Kedar, A. (1997). Primary intracranial germ cell tumors: Clinicopathologic review of 32 cases. Pediatric Pathology and Laboratory Medicine, 17(5), 713-727. https://doi.org/10.1080/15513819709168597