Primary leptomeningeal oligodendroglioma, IDH-Mutant, 1p/19q-Codeleted

Leomar Y. Ballester, Erin Dunbar, Nandita Guha-Thakurta, John W. Henson, Howard Chandler, Jeremiah Watkins, Gregory N. Fuller

Research output: Contribution to journalArticlepeer-review


We present a case of a 43-year-old woman with a history of headaches and blurry vision. Ophthalmologic examination identified papilledema. MR imaging demonstrated a right parietal region mass with patchy areas of contrast enhancement and focal calcifications. Intraoperative examination and exploration revealed an extra-axial mass with no apparent parenchymal involvement. Microscopic examination revealed solid sheets of tumor cells with clear cell cytologic features and no discernable intra-parenchymal tumor component. Molecular studies demonstrated the presence of IDH1 IDH1 c.395G > A p.R132H and CIC c.601C > T p.R281W mutations and 1p/19q codeletion. The radiographic features, gross appearance, and microscopic and molecular characteristics of the mass support the diagnosis of primary leptomeningeal oligodendroglioma, IDH-mutant, 1p/19-codeleted. This case represents one of a very few reported instances of molecularly-defined solitary, primary, intracranial oligodendroglioma, without definitive involvement of the brain parenchyma.

Original languageEnglish (US)
Article number700
JournalFrontiers in Neurology
Issue numberAUG
StatePublished - Aug 27 2018
Externally publishedYes


  • 1p/19q-codeletion
  • ATRX
  • CIC
  • Diffuse glioma
  • FUBP1
  • IDH1
  • Leptomeningeal oligodendroglioma

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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