Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix

Oxana Ibraghimov-Beskrovnaya, James M. Ervasti, Cynthia J. Leveille, Clive A. Slaughter, Suzanne W. Sernett, Kevin P. Campbell

Research output: Contribution to journalArticle

1091 Citations (Scopus)

Abstract

The primary sequence of two components of the dystrophin-glycoprotein complex has been established by complementary DNA cloning. The transmembrane 43K and extracellular 156K dystrophin-associated glycoproteins (DAGs) are encoded by a single messenger RNA and the extracellular 156K DAG binds laminin. Thus, the 156K DAG is a new laminin-binding glycoprotein which may provide a linkage between the sarcolemma and extracellular matrix. These results support the hypothesis that the dramatic reduction in the 156K DAG in Duchenne muscular dystrophy leads to a loss of a linkage between the sarcolemma and extra-cellular matrix and that this may render muscle fibres more susceptible to necrosis.

Original languageEnglish (US)
Pages (from-to)696-702
Number of pages7
JournalNature
Volume355
Issue number6362
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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Dystrophin
Extracellular Matrix
Glycoproteins
Sarcolemma
Laminin
Duchenne Muscular Dystrophy
Organism Cloning
Necrosis
Complementary DNA
Muscles
Messenger RNA

ASJC Scopus subject areas

  • General

Cite this

Ibraghimov-Beskrovnaya, O., Ervasti, J. M., Leveille, C. J., Slaughter, C. A., Sernett, S. W., & Campbell, K. P. (1992). Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature, 355(6362), 696-702. https://doi.org/10.1038/355696a0

Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. / Ibraghimov-Beskrovnaya, Oxana; Ervasti, James M.; Leveille, Cynthia J.; Slaughter, Clive A.; Sernett, Suzanne W.; Campbell, Kevin P.

In: Nature, Vol. 355, No. 6362, 01.01.1992, p. 696-702.

Research output: Contribution to journalArticle

Ibraghimov-Beskrovnaya, O, Ervasti, JM, Leveille, CJ, Slaughter, CA, Sernett, SW & Campbell, KP 1992, 'Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix', Nature, vol. 355, no. 6362, pp. 696-702. https://doi.org/10.1038/355696a0
Ibraghimov-Beskrovnaya O, Ervasti JM, Leveille CJ, Slaughter CA, Sernett SW, Campbell KP. Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature. 1992 Jan 1;355(6362):696-702. https://doi.org/10.1038/355696a0
Ibraghimov-Beskrovnaya, Oxana ; Ervasti, James M. ; Leveille, Cynthia J. ; Slaughter, Clive A. ; Sernett, Suzanne W. ; Campbell, Kevin P. / Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. In: Nature. 1992 ; Vol. 355, No. 6362. pp. 696-702.
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