Principles and mechanisms of peri-implant soft tissue healing

Stefan Schultze-Mosgau, Markus B. Blatz, Falk Wehrhan, Karl Andreas Schlegel, Michael Thorwart, Stefan Holst

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The long-term clinical and esthetic success of implant-supported restorations is determined by osseointegration and optimal remodeling of peri-implant soft tissues. Complications of soft-tissue management are often caused by fibrotic regeneration of oral mucosa after multiple surgical procedures. Knowledge of the proliferative processes in wound healing is necessary to attain adequate soft-tissue conditions. Successful reconstruction of peri-implant soft tissues is feasible even in fibrotic conditions when appropriate surgical techniques are selected. The pleiotropic proliferative cytokine TGF-β is involved in the regulation of all phases of wound healing and tissue remodeling. The isoform TGF-β1 is a cytokine associated with the development of fibrotic tissue. Overexpression of TGF-β1 causes scarring and fibrosis, and results in limited clinical success of intraoral soft-tissue management. Experimental therapeutic approaches with neutralizing antibodies to block TGF-β1 resulted in less scarring and a reduction of fibrosis. Further molecular biologic research of cell-matrix-cytokine interactions in wound healing will provide highly specific antifibrotic therapeutic approaches in the future.

Original languageEnglish (US)
Pages (from-to)759-769
Number of pages11
JournalQuintessence international
Volume36
Issue number10
StatePublished - Nov 1 2005

Fingerprint

Wound Healing
Cytokines
Cicatrix
Fibrosis
Osseointegration
Mouth Mucosa
Neutralizing Antibodies
Esthetics
Regeneration
Protein Isoforms
Therapeutics
Research

Keywords

  • Fibrosis
  • Implants
  • Soft tissue
  • Transforming growth factor-beta
  • Wound healing

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Schultze-Mosgau, S., Blatz, M. B., Wehrhan, F., Schlegel, K. A., Thorwart, M., & Holst, S. (2005). Principles and mechanisms of peri-implant soft tissue healing. Quintessence international, 36(10), 759-769.

Principles and mechanisms of peri-implant soft tissue healing. / Schultze-Mosgau, Stefan; Blatz, Markus B.; Wehrhan, Falk; Schlegel, Karl Andreas; Thorwart, Michael; Holst, Stefan.

In: Quintessence international, Vol. 36, No. 10, 01.11.2005, p. 759-769.

Research output: Contribution to journalArticle

Schultze-Mosgau, S, Blatz, MB, Wehrhan, F, Schlegel, KA, Thorwart, M & Holst, S 2005, 'Principles and mechanisms of peri-implant soft tissue healing', Quintessence international, vol. 36, no. 10, pp. 759-769.
Schultze-Mosgau S, Blatz MB, Wehrhan F, Schlegel KA, Thorwart M, Holst S. Principles and mechanisms of peri-implant soft tissue healing. Quintessence international. 2005 Nov 1;36(10):759-769.
Schultze-Mosgau, Stefan ; Blatz, Markus B. ; Wehrhan, Falk ; Schlegel, Karl Andreas ; Thorwart, Michael ; Holst, Stefan. / Principles and mechanisms of peri-implant soft tissue healing. In: Quintessence international. 2005 ; Vol. 36, No. 10. pp. 759-769.
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