Prior exercise and postprandial incretin responses in lean and obese individuals

Timothy D. Heden, Ying Liu, Monica L. Kearney, Youngmin Park, Kevin C Dellsperger, Tom R. Thomas, Jill A. Kanaley

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

PURPOSE: The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) help regulate postprandial triacylglycerol (TAG) and insulin concentrations, but the effects of acute aerobic exercise on GLP-1 or GIP responses are unclear. The purpose of this study was to determine whether reductions in postprandial TAG and insulin with exercise are associated with GLP-1 and GIP responses. METHODS: Thirteen normal-weight (NW) and 13 obese (Ob) individuals participated in two, 4-d trials in random order including an exercise (EX) and a no exercise (NoEX) trial. Diet was controlled during both trials. The EX trial consisted of 1 h of treadmill walking (55%-60% of V̇O2peak) during the evening of day 3 of the trial, 12 h before a 4-h mixed meal test on day 4, during which frequent blood samples were collected to assess postprandial lipemia, glycemia, insulin, C-peptide, GIP, and GLP-1 responses. Insulin secretion was estimated using the insulinogenic index, and insulin clearance was estimated using the ratio of insulin to C-peptide. RESULTS: Postprandial TAG were 29% lower after EX in Ob individuals (P < 0.05) but were not significantly altered in NW individuals (P > 0.05). The drop in postprandial HDL cholesterol was attenuated with EX in Ob individuals (P < 0.05). Insulin responses were 14% lower after EX in Ob individuals (P < 0.05), and this was associated with reduced insulin secretion (P < 0.05), with no change in insulin clearance (P > 0.05). Glucose, C-peptide, GIP, and GLP-1 were not different between trials. CONCLUSION: A 1-h bout of moderate-intensity aerobic exercise the night before a mixed meal attenuates TAG and insulin responses in Ob but not NW individuals, an effect not associated with altered GLP-1 or GIP responses.

Original languageEnglish (US)
Pages (from-to)1897-1905
Number of pages9
JournalMedicine and Science in Sports and Exercise
Volume45
Issue number10
DOIs
StatePublished - Oct 1 2013

Fingerprint

Incretins
Glucagon-Like Peptide 1
Insulin
Glucose
Peptides
C-Peptide
Triglycerides
Exercise
Meals
Weights and Measures
Hyperlipidemias
HDL Cholesterol
Walking
Hormones
Diet

Keywords

  • Glucagon-like peptide 1
  • Glucose-dependent insulinotropic polypeptide
  • Insulin
  • Lipemia
  • Obesity
  • Physical activity

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Heden, T. D., Liu, Y., Kearney, M. L., Park, Y., Dellsperger, K. C., Thomas, T. R., & Kanaley, J. A. (2013). Prior exercise and postprandial incretin responses in lean and obese individuals. Medicine and Science in Sports and Exercise, 45(10), 1897-1905. https://doi.org/10.1249/MSS.0b013e318294b225

Prior exercise and postprandial incretin responses in lean and obese individuals. / Heden, Timothy D.; Liu, Ying; Kearney, Monica L.; Park, Youngmin; Dellsperger, Kevin C; Thomas, Tom R.; Kanaley, Jill A.

In: Medicine and Science in Sports and Exercise, Vol. 45, No. 10, 01.10.2013, p. 1897-1905.

Research output: Contribution to journalArticle

Heden, TD, Liu, Y, Kearney, ML, Park, Y, Dellsperger, KC, Thomas, TR & Kanaley, JA 2013, 'Prior exercise and postprandial incretin responses in lean and obese individuals', Medicine and Science in Sports and Exercise, vol. 45, no. 10, pp. 1897-1905. https://doi.org/10.1249/MSS.0b013e318294b225
Heden, Timothy D. ; Liu, Ying ; Kearney, Monica L. ; Park, Youngmin ; Dellsperger, Kevin C ; Thomas, Tom R. ; Kanaley, Jill A. / Prior exercise and postprandial incretin responses in lean and obese individuals. In: Medicine and Science in Sports and Exercise. 2013 ; Vol. 45, No. 10. pp. 1897-1905.
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abstract = "PURPOSE: The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) help regulate postprandial triacylglycerol (TAG) and insulin concentrations, but the effects of acute aerobic exercise on GLP-1 or GIP responses are unclear. The purpose of this study was to determine whether reductions in postprandial TAG and insulin with exercise are associated with GLP-1 and GIP responses. METHODS: Thirteen normal-weight (NW) and 13 obese (Ob) individuals participated in two, 4-d trials in random order including an exercise (EX) and a no exercise (NoEX) trial. Diet was controlled during both trials. The EX trial consisted of 1 h of treadmill walking (55{\%}-60{\%} of V̇O2peak) during the evening of day 3 of the trial, 12 h before a 4-h mixed meal test on day 4, during which frequent blood samples were collected to assess postprandial lipemia, glycemia, insulin, C-peptide, GIP, and GLP-1 responses. Insulin secretion was estimated using the insulinogenic index, and insulin clearance was estimated using the ratio of insulin to C-peptide. RESULTS: Postprandial TAG were 29{\%} lower after EX in Ob individuals (P < 0.05) but were not significantly altered in NW individuals (P > 0.05). The drop in postprandial HDL cholesterol was attenuated with EX in Ob individuals (P < 0.05). Insulin responses were 14{\%} lower after EX in Ob individuals (P < 0.05), and this was associated with reduced insulin secretion (P < 0.05), with no change in insulin clearance (P > 0.05). Glucose, C-peptide, GIP, and GLP-1 were not different between trials. CONCLUSION: A 1-h bout of moderate-intensity aerobic exercise the night before a mixed meal attenuates TAG and insulin responses in Ob but not NW individuals, an effect not associated with altered GLP-1 or GIP responses.",
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AU - Thomas, Tom R.

AU - Kanaley, Jill A.

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N2 - PURPOSE: The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) help regulate postprandial triacylglycerol (TAG) and insulin concentrations, but the effects of acute aerobic exercise on GLP-1 or GIP responses are unclear. The purpose of this study was to determine whether reductions in postprandial TAG and insulin with exercise are associated with GLP-1 and GIP responses. METHODS: Thirteen normal-weight (NW) and 13 obese (Ob) individuals participated in two, 4-d trials in random order including an exercise (EX) and a no exercise (NoEX) trial. Diet was controlled during both trials. The EX trial consisted of 1 h of treadmill walking (55%-60% of V̇O2peak) during the evening of day 3 of the trial, 12 h before a 4-h mixed meal test on day 4, during which frequent blood samples were collected to assess postprandial lipemia, glycemia, insulin, C-peptide, GIP, and GLP-1 responses. Insulin secretion was estimated using the insulinogenic index, and insulin clearance was estimated using the ratio of insulin to C-peptide. RESULTS: Postprandial TAG were 29% lower after EX in Ob individuals (P < 0.05) but were not significantly altered in NW individuals (P > 0.05). The drop in postprandial HDL cholesterol was attenuated with EX in Ob individuals (P < 0.05). Insulin responses were 14% lower after EX in Ob individuals (P < 0.05), and this was associated with reduced insulin secretion (P < 0.05), with no change in insulin clearance (P > 0.05). Glucose, C-peptide, GIP, and GLP-1 were not different between trials. CONCLUSION: A 1-h bout of moderate-intensity aerobic exercise the night before a mixed meal attenuates TAG and insulin responses in Ob but not NW individuals, an effect not associated with altered GLP-1 or GIP responses.

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