Abstract
Nephrotoxicity is a major side effect during chemotherapy with cisplatin and related platinum compounds. Previous work unveiled a role of PRKCD/PKCδ (protein kinase C delta) in cisplatin-induced nephrotoxicity; however, the underlying mechanism was largely unknown. Our recent work showed that PRKCD may suppress macroautophagy/autophagy, a cytoprotective mechanism, to promote kidney tubule cell death during cisplatin treatment. Interestingly, PRKCD may do so by phosphorylating AKT, which further phosphorylates MTOR to repress ULK1.
Original language | English (US) |
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Pages (from-to) | 631-632 |
Number of pages | 2 |
Journal | Autophagy |
Volume | 13 |
Issue number | 3 |
DOIs |
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State | Published - Mar 4 2017 |
Keywords
- AKT
- MTOR
- PKCδ
- autophagy
- chemotherapy
- cisplatin
- kidney
- nephrotoxicity
- side effect
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology