Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer

R. G. Wiggans, R. J. Jacobson, P. J. Fialkow, P. V. Woolley IIIrd, J. S. Macdonald, P. S. Schein

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42 Scopus citations

Abstract

A 64-yr-old female developed acute myeloblastic leukemia following radiation and drug therapy for colon carcinoma. The patient was heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD) and displayed types A and B isoenzymes in nonhematopoietic tissue. In contrast, only type B G-6-PD was observed in peripheral blood white cells. In addition, a karyotypic abnormality was found in peripheral blood and marrow cells but not in skin fibroblasts. The data are consistent with a clonal origin of this leukemia.

Original languageEnglish (US)
Pages (from-to)659-663
Number of pages5
JournalBlood
Volume52
Issue number4
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Hematology

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    Wiggans, R. G., Jacobson, R. J., Fialkow, P. J., Woolley IIIrd, P. V., Macdonald, J. S., & Schein, P. S. (1978). Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer. Blood, 52(4), 659-663.