Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer

R. G. Wiggans, R. J. Jacobson, P. J. Fialkow, P. V. Woolley IIIrd, J. S. Macdonald, P. S. Schein

Research output: Contribution to journalArticle

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Abstract

A 64-yr-old female developed acute myeloblastic leukemia following radiation and drug therapy for colon carcinoma. The patient was heterozygous for glucose-6-phosphate dehydrogenase (G-6-PD) and displayed types A and B isoenzymes in nonhematopoietic tissue. In contrast, only type B G-6-PD was observed in peripheral blood white cells. In addition, a karyotypic abnormality was found in peripheral blood and marrow cells but not in skin fibroblasts. The data are consistent with a clonal origin of this leukemia.

Original languageEnglish (US)
Pages (from-to)659-663
Number of pages5
JournalBlood
Volume52
Issue number4
StatePublished - Dec 1 1978

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Chemotherapy
Glucosephosphate Dehydrogenase
Acute Myeloid Leukemia
Colonic Neoplasms
Isoenzymes
Blood Cells
Colon
Leukemia
Leukocytes
Blood
Radiotherapy
Fibroblasts
Bone Marrow
Radiation
Carcinoma
Drug therapy
Drug Therapy
Skin
Cells
Tissue

ASJC Scopus subject areas

  • Hematology

Cite this

Wiggans, R. G., Jacobson, R. J., Fialkow, P. J., Woolley IIIrd, P. V., Macdonald, J. S., & Schein, P. S. (1978). Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer. Blood, 52(4), 659-663.

Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer. / Wiggans, R. G.; Jacobson, R. J.; Fialkow, P. J.; Woolley IIIrd, P. V.; Macdonald, J. S.; Schein, P. S.

In: Blood, Vol. 52, No. 4, 01.12.1978, p. 659-663.

Research output: Contribution to journalArticle

Wiggans, RG, Jacobson, RJ, Fialkow, PJ, Woolley IIIrd, PV, Macdonald, JS & Schein, PS 1978, 'Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer', Blood, vol. 52, no. 4, pp. 659-663.
Wiggans RG, Jacobson RJ, Fialkow PJ, Woolley IIIrd PV, Macdonald JS, Schein PS. Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer. Blood. 1978 Dec 1;52(4):659-663.
Wiggans, R. G. ; Jacobson, R. J. ; Fialkow, P. J. ; Woolley IIIrd, P. V. ; Macdonald, J. S. ; Schein, P. S. / Probable clonal origin of acute myeloblastic leukemia following radiation and chemotherapy of colon cancer. In: Blood. 1978 ; Vol. 52, No. 4. pp. 659-663.
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