Prognostic factors for alveolar regeneration: Effect of tissue occlusion on alveolar bone regeneration with guided tissue regeneration

Giuseppe Polimeni, Ki Tae Koo, Mohammed Qahash, Andreas V. Xiropaidis, Jasim M. Albandar, Ulf M E Wikesjö

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives: Design criteria for guided tissue regeneration (GTR) devices include biocompatibility, cell occlusion, space-provision, tissue integration, and ease of use. The objective of this study was to evaluate the effect of cell occlusion and space-provision on alveolar bone regeneration in conjunction with GTR. Methods: Routine, critical-size, 6 mm, supra-alveolar, periodontal defects were created in 6 young adult Beagle dogs. Space-providing ePTFE devices, with or without 300-μm laser-drilled pores were implanted to provide for GTR. Treatments were alternated between left and right jaw quadrants in subsequent animals. The gingival flaps were advanced for primary intention healing. The animals were euthanized at week 8 post surgery. The histometric analysis assessed regeneration of alveolar bone relative to space-provision by the ePTFE device. Results: A significant relationship was observed between bone regeneration and space-provision for defect sites receiving the occlusive (β = 0.194; p < 0.02) and porous (β = 0.229; p < 0.0004) GTR devices irrespective of treatment (p = 0.14). The bivariate analysis showed that both space-provision and device occlusivity significantly enhanced bone regeneration. Hence, sites receiving the occlusive GTR device and sites with enhanced space-provision showed significantly greater bone regeneration compared to sites receiving the porous GTR device (p = 0.03) or more limited space-provision (p = 0.0002). Conclusions: Cell occlusion and space-provision may significantly influence the magnitude of alveolar bone regeneration in conjunction with guided tissue regeneration.

Original languageEnglish (US)
Pages (from-to)730-735
Number of pages6
JournalJournal of Clinical Periodontology
Volume31
Issue number9
DOIs
StatePublished - Sep 1 2004

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Guided Tissue Regeneration
Bone Regeneration
Regeneration
Equipment and Supplies
Jaw
Young Adult
Lasers
Dogs
Therapeutics

Keywords

  • Alveolar bone
  • Dogs
  • ePTFE devices
  • Guided tissue regeneration
  • Tissue engineering

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Prognostic factors for alveolar regeneration : Effect of tissue occlusion on alveolar bone regeneration with guided tissue regeneration. / Polimeni, Giuseppe; Koo, Ki Tae; Qahash, Mohammed; Xiropaidis, Andreas V.; Albandar, Jasim M.; Wikesjö, Ulf M E.

In: Journal of Clinical Periodontology, Vol. 31, No. 9, 01.09.2004, p. 730-735.

Research output: Contribution to journalArticle

Polimeni, Giuseppe ; Koo, Ki Tae ; Qahash, Mohammed ; Xiropaidis, Andreas V. ; Albandar, Jasim M. ; Wikesjö, Ulf M E. / Prognostic factors for alveolar regeneration : Effect of tissue occlusion on alveolar bone regeneration with guided tissue regeneration. In: Journal of Clinical Periodontology. 2004 ; Vol. 31, No. 9. pp. 730-735.
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abstract = "Objectives: Design criteria for guided tissue regeneration (GTR) devices include biocompatibility, cell occlusion, space-provision, tissue integration, and ease of use. The objective of this study was to evaluate the effect of cell occlusion and space-provision on alveolar bone regeneration in conjunction with GTR. Methods: Routine, critical-size, 6 mm, supra-alveolar, periodontal defects were created in 6 young adult Beagle dogs. Space-providing ePTFE devices, with or without 300-μm laser-drilled pores were implanted to provide for GTR. Treatments were alternated between left and right jaw quadrants in subsequent animals. The gingival flaps were advanced for primary intention healing. The animals were euthanized at week 8 post surgery. The histometric analysis assessed regeneration of alveolar bone relative to space-provision by the ePTFE device. Results: A significant relationship was observed between bone regeneration and space-provision for defect sites receiving the occlusive (β = 0.194; p < 0.02) and porous (β = 0.229; p < 0.0004) GTR devices irrespective of treatment (p = 0.14). The bivariate analysis showed that both space-provision and device occlusivity significantly enhanced bone regeneration. Hence, sites receiving the occlusive GTR device and sites with enhanced space-provision showed significantly greater bone regeneration compared to sites receiving the porous GTR device (p = 0.03) or more limited space-provision (p = 0.0002). Conclusions: Cell occlusion and space-provision may significantly influence the magnitude of alveolar bone regeneration in conjunction with guided tissue regeneration.",
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