TY - JOUR
T1 - Prognostic factors for alveolar regeneration
T2 - Effect of tissue occlusion on alveolar bone regeneration with guided tissue regeneration
AU - Polimeni, Giuseppe
AU - Koo, Ki Tae
AU - Qahash, Mohammed
AU - Xiropaidis, Andreas V.
AU - Albandar, Jasim M.
AU - Wikesjö, Ulf M E
PY - 2004/9
Y1 - 2004/9
N2 - Objectives: Design criteria for guided tissue regeneration (GTR) devices include biocompatibility, cell occlusion, space-provision, tissue integration, and ease of use. The objective of this study was to evaluate the effect of cell occlusion and space-provision on alveolar bone regeneration in conjunction with GTR. Methods: Routine, critical-size, 6 mm, supra-alveolar, periodontal defects were created in 6 young adult Beagle dogs. Space-providing ePTFE devices, with or without 300-μm laser-drilled pores were implanted to provide for GTR. Treatments were alternated between left and right jaw quadrants in subsequent animals. The gingival flaps were advanced for primary intention healing. The animals were euthanized at week 8 post surgery. The histometric analysis assessed regeneration of alveolar bone relative to space-provision by the ePTFE device. Results: A significant relationship was observed between bone regeneration and space-provision for defect sites receiving the occlusive (β = 0.194; p < 0.02) and porous (β = 0.229; p < 0.0004) GTR devices irrespective of treatment (p = 0.14). The bivariate analysis showed that both space-provision and device occlusivity significantly enhanced bone regeneration. Hence, sites receiving the occlusive GTR device and sites with enhanced space-provision showed significantly greater bone regeneration compared to sites receiving the porous GTR device (p = 0.03) or more limited space-provision (p = 0.0002). Conclusions: Cell occlusion and space-provision may significantly influence the magnitude of alveolar bone regeneration in conjunction with guided tissue regeneration.
AB - Objectives: Design criteria for guided tissue regeneration (GTR) devices include biocompatibility, cell occlusion, space-provision, tissue integration, and ease of use. The objective of this study was to evaluate the effect of cell occlusion and space-provision on alveolar bone regeneration in conjunction with GTR. Methods: Routine, critical-size, 6 mm, supra-alveolar, periodontal defects were created in 6 young adult Beagle dogs. Space-providing ePTFE devices, with or without 300-μm laser-drilled pores were implanted to provide for GTR. Treatments were alternated between left and right jaw quadrants in subsequent animals. The gingival flaps were advanced for primary intention healing. The animals were euthanized at week 8 post surgery. The histometric analysis assessed regeneration of alveolar bone relative to space-provision by the ePTFE device. Results: A significant relationship was observed between bone regeneration and space-provision for defect sites receiving the occlusive (β = 0.194; p < 0.02) and porous (β = 0.229; p < 0.0004) GTR devices irrespective of treatment (p = 0.14). The bivariate analysis showed that both space-provision and device occlusivity significantly enhanced bone regeneration. Hence, sites receiving the occlusive GTR device and sites with enhanced space-provision showed significantly greater bone regeneration compared to sites receiving the porous GTR device (p = 0.03) or more limited space-provision (p = 0.0002). Conclusions: Cell occlusion and space-provision may significantly influence the magnitude of alveolar bone regeneration in conjunction with guided tissue regeneration.
KW - Alveolar bone
KW - Dogs
KW - Guided tissue regeneration
KW - Tissue engineering
KW - ePTFE devices
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U2 - 10.1111/j.1600-051X.2004.00543.x
DO - 10.1111/j.1600-051X.2004.00543.x
M3 - Article
C2 - 15312094
AN - SCOPUS:4444245384
SN - 0303-6979
VL - 31
SP - 730
EP - 735
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 9
ER -