Prognostic indicators for squamous cell carcinoma of the oral cavity: A clinicopathologic correlation

Jack L. Gluckman, Zlatko P. Pavelic, Hans Jurgen Welkoborsky, Wolf Mann, Peter Stambrook, Lyon Gleich, Keith Wilson, Paul Righi, Louis G. Portugal, John McDonald, Paul Williams Biddinger, David Steward, Peter Gartside

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Fifty-three patients with T1 squamous cell cancer of the floor of mouth and ventral surface of the tongue with a known clinical outcome were retrospectively analyzed and arbitrarily divided into 'aggressive' and 'nonaggressive' groups based on their clinical behavior. Various host and tumor factors were then evaluated in an attempt to determine whether the tumor behavior could have been predicted. The paraffin-embedded tumor specimens were evaluated for tumor differentiation, tumor thickness and tumor invasion, microvessel density, and p53 expression. In addition, a composite morphologic grading score was obtained by combining cell differentiation, nuclear polymorphism, mitosis activity, depth of infiltration, type of infiltration, and lymphatic infiltration. No single technique appeared capable of identifying 'aggressive behavior, although possibly an evaluation of composite factors might show promise in the future.

Original languageEnglish (US)
Pages (from-to)1239-1240
Number of pages2
Issue number9
StatePublished - Sep 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Otorhinolaryngology


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