Prognostic indicators for squamous cell carcinoma of the oral cavity

A clinicopathologic correlation

Jack L. Gluckman, Zlatko P. Pavelic, Hans Jurgen Welkoborsky, Wolf Mann, Peter Stambrook, Lyon Gleich, Keith Wilson, Paul Righi, Louis G. Portugal, John McDonald, Paul Williams Biddinger, David Steward, Peter Gartside

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Fifty-three patients with T1 squamous cell cancer of the floor of mouth and ventral surface of the tongue with a known clinical outcome were retrospectively analyzed and arbitrarily divided into 'aggressive' and 'nonaggressive' groups based on their clinical behavior. Various host and tumor factors were then evaluated in an attempt to determine whether the tumor behavior could have been predicted. The paraffin-embedded tumor specimens were evaluated for tumor differentiation, tumor thickness and tumor invasion, microvessel density, and p53 expression. In addition, a composite morphologic grading score was obtained by combining cell differentiation, nuclear polymorphism, mitosis activity, depth of infiltration, type of infiltration, and lymphatic infiltration. No single technique appeared capable of identifying 'aggressive behavior, although possibly an evaluation of composite factors might show promise in the future.

Original languageEnglish (US)
Pages (from-to)1239-1240
Number of pages2
JournalLaryngoscope
Volume107
Issue number9
DOIs
StatePublished - Sep 1 1997
Externally publishedYes

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Mouth
Squamous Cell Carcinoma
Neoplasms
Mouth Floor
Squamous Cell Neoplasms
Mouth Neoplasms
Microvessels
Tongue
Mitosis
Paraffin
Cell Differentiation

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Gluckman, J. L., Pavelic, Z. P., Welkoborsky, H. J., Mann, W., Stambrook, P., Gleich, L., ... Gartside, P. (1997). Prognostic indicators for squamous cell carcinoma of the oral cavity: A clinicopathologic correlation. Laryngoscope, 107(9), 1239-1240. https://doi.org/10.1097/00005537-199709000-00015

Prognostic indicators for squamous cell carcinoma of the oral cavity : A clinicopathologic correlation. / Gluckman, Jack L.; Pavelic, Zlatko P.; Welkoborsky, Hans Jurgen; Mann, Wolf; Stambrook, Peter; Gleich, Lyon; Wilson, Keith; Righi, Paul; Portugal, Louis G.; McDonald, John; Biddinger, Paul Williams; Steward, David; Gartside, Peter.

In: Laryngoscope, Vol. 107, No. 9, 01.09.1997, p. 1239-1240.

Research output: Contribution to journalArticle

Gluckman, JL, Pavelic, ZP, Welkoborsky, HJ, Mann, W, Stambrook, P, Gleich, L, Wilson, K, Righi, P, Portugal, LG, McDonald, J, Biddinger, PW, Steward, D & Gartside, P 1997, 'Prognostic indicators for squamous cell carcinoma of the oral cavity: A clinicopathologic correlation', Laryngoscope, vol. 107, no. 9, pp. 1239-1240. https://doi.org/10.1097/00005537-199709000-00015
Gluckman JL, Pavelic ZP, Welkoborsky HJ, Mann W, Stambrook P, Gleich L et al. Prognostic indicators for squamous cell carcinoma of the oral cavity: A clinicopathologic correlation. Laryngoscope. 1997 Sep 1;107(9):1239-1240. https://doi.org/10.1097/00005537-199709000-00015
Gluckman, Jack L. ; Pavelic, Zlatko P. ; Welkoborsky, Hans Jurgen ; Mann, Wolf ; Stambrook, Peter ; Gleich, Lyon ; Wilson, Keith ; Righi, Paul ; Portugal, Louis G. ; McDonald, John ; Biddinger, Paul Williams ; Steward, David ; Gartside, Peter. / Prognostic indicators for squamous cell carcinoma of the oral cavity : A clinicopathologic correlation. In: Laryngoscope. 1997 ; Vol. 107, No. 9. pp. 1239-1240.
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