Progress on new vaccine strategies against chronic viral infections

Jay A. Berzofsky, Jeffrey D. Ahlers, John Edward Janik, John Morris, Sang Kon Oh, Masaki Terabe, Igor M. Belyakov

Research output: Contribution to journalReview article

110 Citations (Scopus)

Abstract

Among the most cost-effective strategies for preventing viral infections, vaccines have proven effective primarily against viruses causing acute, self-limited infections. For these it has been sufficient for die vaccine to mimic the natural virus. However, viruses causing chronic infection do not elicit an immune response sufficient to clear the infection and, as a result, vaccines for these viruses must elicit more effective responses - quantitative and qualitative - than does the natural virus. Here we examine the immunologic and virologic basis for vaccines against three such viruses, HIV, hepatitis C virus, and human papillomavirus, and review progress in clinical trials to date. We also explore novel strategies for increasing the immunogenicity and efficacy of vaccines.

Original languageEnglish (US)
Pages (from-to)450-462
Number of pages13
JournalJournal of Clinical Investigation
Volume114
Issue number4
DOIs
StatePublished - Aug 1 2004

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Virus Diseases
Vaccines
Viruses
Infection
Viral Vaccines
Hepacivirus
Clinical Trials
HIV
Costs and Cost Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Berzofsky, J. A., Ahlers, J. D., Janik, J. E., Morris, J., Oh, S. K., Terabe, M., & Belyakov, I. M. (2004). Progress on new vaccine strategies against chronic viral infections. Journal of Clinical Investigation, 114(4), 450-462. https://doi.org/10.1172/JCI200422674

Progress on new vaccine strategies against chronic viral infections. / Berzofsky, Jay A.; Ahlers, Jeffrey D.; Janik, John Edward; Morris, John; Oh, Sang Kon; Terabe, Masaki; Belyakov, Igor M.

In: Journal of Clinical Investigation, Vol. 114, No. 4, 01.08.2004, p. 450-462.

Research output: Contribution to journalReview article

Berzofsky, JA, Ahlers, JD, Janik, JE, Morris, J, Oh, SK, Terabe, M & Belyakov, IM 2004, 'Progress on new vaccine strategies against chronic viral infections', Journal of Clinical Investigation, vol. 114, no. 4, pp. 450-462. https://doi.org/10.1172/JCI200422674
Berzofsky JA, Ahlers JD, Janik JE, Morris J, Oh SK, Terabe M et al. Progress on new vaccine strategies against chronic viral infections. Journal of Clinical Investigation. 2004 Aug 1;114(4):450-462. https://doi.org/10.1172/JCI200422674
Berzofsky, Jay A. ; Ahlers, Jeffrey D. ; Janik, John Edward ; Morris, John ; Oh, Sang Kon ; Terabe, Masaki ; Belyakov, Igor M. / Progress on new vaccine strategies against chronic viral infections. In: Journal of Clinical Investigation. 2004 ; Vol. 114, No. 4. pp. 450-462.
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