Proinflammatory phenotype of perivascular adipocytes

Influence of high-fat feeding

Tapan Kumar Chatterjee, Lynn L. Stoll, Gerene M. Denning, Allan Harrelson, Andra L. Blomkalns, Gila Idelman, Florence G. Rothenberg, Bonnie Neltner, Sara A. Romig-Martin, Eric W. Dickson, Steven Rudich, Neal Lee Weintraub

Research output: Contribution to journalArticle

300 Citations (Scopus)

Abstract

Adipose tissue depots originate from distinct precursor cells, are functionally diverse, and modulate disease processes in a depot-specific manner. However, the functional properties of perivascular adipocytes, and their influence on disease of the blood vessel wall, remain to be determined. We show that human coronary perivascular adipocytes exhibit a reduced state of adipocytic differentiation as compared with adipocytes derived from subcutaneous and visceral (perirenal) adipose depots. Secretion of antiinflammatory adiponectin is markedly reduced, whereas that of proinflammatory cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1, is markedly increased in perivascular adipocytes. These depot-specific differences in adipocyte function are demonstrable in both freshly isolated adipose tissues and in vitro-differentiated adipocytes. Murine aortic arch perivascular adipose tissues likewise express lower levels of adipocyte-associated genes as compared with subcutaneous and visceral adipose tissues. Moreover, 2 weeks of high-fat feeding caused further reductions in adipocyte-associated gene expression, while upregulating proinflammatory gene expression, in perivascular adipose tissues. These changes were observed in the absence of macrophage recruitment to the perivascular adipose depot. We conclude that perivascular adipocytes exhibit reduced differentiation and a heightened proinflammatory state, properties that are intrinsic to the adipocytes residing in this depot. Dysfunction of perivascular adipose tissue induced by fat feeding suggests that this unique adipose depot is capable of linking metabolic signals to inflammation in the blood vessel wall.

Original languageEnglish (US)
Pages (from-to)541-549
Number of pages9
JournalCirculation research
Volume104
Issue number4
DOIs
StatePublished - Feb 27 2009

Fingerprint

Adipocytes
Fats
Phenotype
Adipose Tissue
Blood Vessels
Gene Expression
Intra-Abdominal Fat
Chemokine CCL2
Subcutaneous Fat
Adiponectin
Thoracic Aorta
Interleukin-8
Interleukin-6
Anti-Inflammatory Agents
Macrophages
Cytokines
Inflammation

Keywords

  • Adipocytes
  • Adipokines
  • Adventitia
  • Cytokines
  • Perivascular adipose tissue

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Chatterjee, T. K., Stoll, L. L., Denning, G. M., Harrelson, A., Blomkalns, A. L., Idelman, G., ... Weintraub, N. L. (2009). Proinflammatory phenotype of perivascular adipocytes: Influence of high-fat feeding. Circulation research, 104(4), 541-549. https://doi.org/10.1161/CIRCRESAHA.108.182998

Proinflammatory phenotype of perivascular adipocytes : Influence of high-fat feeding. / Chatterjee, Tapan Kumar; Stoll, Lynn L.; Denning, Gerene M.; Harrelson, Allan; Blomkalns, Andra L.; Idelman, Gila; Rothenberg, Florence G.; Neltner, Bonnie; Romig-Martin, Sara A.; Dickson, Eric W.; Rudich, Steven; Weintraub, Neal Lee.

In: Circulation research, Vol. 104, No. 4, 27.02.2009, p. 541-549.

Research output: Contribution to journalArticle

Chatterjee, TK, Stoll, LL, Denning, GM, Harrelson, A, Blomkalns, AL, Idelman, G, Rothenberg, FG, Neltner, B, Romig-Martin, SA, Dickson, EW, Rudich, S & Weintraub, NL 2009, 'Proinflammatory phenotype of perivascular adipocytes: Influence of high-fat feeding', Circulation research, vol. 104, no. 4, pp. 541-549. https://doi.org/10.1161/CIRCRESAHA.108.182998
Chatterjee TK, Stoll LL, Denning GM, Harrelson A, Blomkalns AL, Idelman G et al. Proinflammatory phenotype of perivascular adipocytes: Influence of high-fat feeding. Circulation research. 2009 Feb 27;104(4):541-549. https://doi.org/10.1161/CIRCRESAHA.108.182998
Chatterjee, Tapan Kumar ; Stoll, Lynn L. ; Denning, Gerene M. ; Harrelson, Allan ; Blomkalns, Andra L. ; Idelman, Gila ; Rothenberg, Florence G. ; Neltner, Bonnie ; Romig-Martin, Sara A. ; Dickson, Eric W. ; Rudich, Steven ; Weintraub, Neal Lee. / Proinflammatory phenotype of perivascular adipocytes : Influence of high-fat feeding. In: Circulation research. 2009 ; Vol. 104, No. 4. pp. 541-549.
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AU - Rothenberg, Florence G.

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