Project among African-Americans to explore risks for schizophrenia (PAARTNERS): Recruitment and assessment methods

Muktar H. Aliyu, Monica E. Calkins, Charlie L. Swanson, Paul D. Lyons, Robert M. Savage, Roberta May, Howard Wiener, Bernie Devlin, Vishwajit L. Nimgaonkar, J. Daniel Ragland, Raquel E. Gur, Ruben C. Gur, L. Dianne Bradford, Neil Edwards, Joseph Kwentus, Joseph Patrick McEvoy, Alberto Santos, Stephen McCleod-Bryant, Clifton Tennison, Rodney C.P. Go

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The Project among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) is a multi-site, NIMH-funded study that seeks to identify genetic polymorphisms that confer susceptibility to schizophrenia among African-Americans by linkage mapping and targeted association analyses. Because deficits in certain dimensions of cognitive ability are thought to underlie liability to schizophrenia, the project also examines cognitive abilities in individuals affected by schizophrenia and their extended family members. This article describes PAARTNERS study design, ascertainment methods and preliminary sample characteristics. We aim to recruit a sample of 1260 African-American families, all of whom have at least one proband with schizophrenia or schizoaffective disorder. The data collection protocol includes a structured Diagnostic Interview for Genetic Studies, Family Interview for Genetic Studies, focused neurocognitive assessment, medical records review, and the collection of blood or buccal cells for genetic analyses. We have currently completed study procedures for 106 affected sib-pair, 457 case-parent trio and 23 multiplex families. A total of 289 probands have completed the best estimate final diagnosis process and 1153 probands and family members have been administered the computerized neuropsychological battery. This project lays the foundation for future analysis of cognitive and behavioral endophenotypes. This novel integration of diagnostic, neurocognitive and genetic data will also generate valuable information for future phenotypic and genetic studies of schizophrenia.

Original languageEnglish (US)
Pages (from-to)32-44
Number of pages13
JournalSchizophrenia Research
Volume87
Issue number1-3
DOIs
StatePublished - Jan 1 2006

Fingerprint

African Americans
Schizophrenia
Aptitude
Interviews
Endophenotypes
National Institute of Mental Health (U.S.)
Cheek
Chromosome Mapping
Genetic Polymorphisms
Psychotic Disorders
Medical Records

Keywords

  • African-American
  • Endophenotype
  • Genetics
  • Neurocognitive
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Aliyu, M. H., Calkins, M. E., Swanson, C. L., Lyons, P. D., Savage, R. M., May, R., ... Go, R. C. P. (2006). Project among African-Americans to explore risks for schizophrenia (PAARTNERS): Recruitment and assessment methods. Schizophrenia Research, 87(1-3), 32-44. https://doi.org/10.1016/j.schres.2006.06.027

Project among African-Americans to explore risks for schizophrenia (PAARTNERS) : Recruitment and assessment methods. / Aliyu, Muktar H.; Calkins, Monica E.; Swanson, Charlie L.; Lyons, Paul D.; Savage, Robert M.; May, Roberta; Wiener, Howard; Devlin, Bernie; Nimgaonkar, Vishwajit L.; Ragland, J. Daniel; Gur, Raquel E.; Gur, Ruben C.; Bradford, L. Dianne; Edwards, Neil; Kwentus, Joseph; McEvoy, Joseph Patrick; Santos, Alberto; McCleod-Bryant, Stephen; Tennison, Clifton; Go, Rodney C.P.

In: Schizophrenia Research, Vol. 87, No. 1-3, 01.01.2006, p. 32-44.

Research output: Contribution to journalArticle

Aliyu, MH, Calkins, ME, Swanson, CL, Lyons, PD, Savage, RM, May, R, Wiener, H, Devlin, B, Nimgaonkar, VL, Ragland, JD, Gur, RE, Gur, RC, Bradford, LD, Edwards, N, Kwentus, J, McEvoy, JP, Santos, A, McCleod-Bryant, S, Tennison, C & Go, RCP 2006, 'Project among African-Americans to explore risks for schizophrenia (PAARTNERS): Recruitment and assessment methods', Schizophrenia Research, vol. 87, no. 1-3, pp. 32-44. https://doi.org/10.1016/j.schres.2006.06.027
Aliyu, Muktar H. ; Calkins, Monica E. ; Swanson, Charlie L. ; Lyons, Paul D. ; Savage, Robert M. ; May, Roberta ; Wiener, Howard ; Devlin, Bernie ; Nimgaonkar, Vishwajit L. ; Ragland, J. Daniel ; Gur, Raquel E. ; Gur, Ruben C. ; Bradford, L. Dianne ; Edwards, Neil ; Kwentus, Joseph ; McEvoy, Joseph Patrick ; Santos, Alberto ; McCleod-Bryant, Stephen ; Tennison, Clifton ; Go, Rodney C.P. / Project among African-Americans to explore risks for schizophrenia (PAARTNERS) : Recruitment and assessment methods. In: Schizophrenia Research. 2006 ; Vol. 87, No. 1-3. pp. 32-44.
@article{6749d1a0cd004ee6985798638a4b8f47,
title = "Project among African-Americans to explore risks for schizophrenia (PAARTNERS): Recruitment and assessment methods",
abstract = "The Project among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) is a multi-site, NIMH-funded study that seeks to identify genetic polymorphisms that confer susceptibility to schizophrenia among African-Americans by linkage mapping and targeted association analyses. Because deficits in certain dimensions of cognitive ability are thought to underlie liability to schizophrenia, the project also examines cognitive abilities in individuals affected by schizophrenia and their extended family members. This article describes PAARTNERS study design, ascertainment methods and preliminary sample characteristics. We aim to recruit a sample of 1260 African-American families, all of whom have at least one proband with schizophrenia or schizoaffective disorder. The data collection protocol includes a structured Diagnostic Interview for Genetic Studies, Family Interview for Genetic Studies, focused neurocognitive assessment, medical records review, and the collection of blood or buccal cells for genetic analyses. We have currently completed study procedures for 106 affected sib-pair, 457 case-parent trio and 23 multiplex families. A total of 289 probands have completed the best estimate final diagnosis process and 1153 probands and family members have been administered the computerized neuropsychological battery. This project lays the foundation for future analysis of cognitive and behavioral endophenotypes. This novel integration of diagnostic, neurocognitive and genetic data will also generate valuable information for future phenotypic and genetic studies of schizophrenia.",
keywords = "African-American, Endophenotype, Genetics, Neurocognitive, Schizophrenia",
author = "Aliyu, {Muktar H.} and Calkins, {Monica E.} and Swanson, {Charlie L.} and Lyons, {Paul D.} and Savage, {Robert M.} and Roberta May and Howard Wiener and Bernie Devlin and Nimgaonkar, {Vishwajit L.} and Ragland, {J. Daniel} and Gur, {Raquel E.} and Gur, {Ruben C.} and Bradford, {L. Dianne} and Neil Edwards and Joseph Kwentus and McEvoy, {Joseph Patrick} and Alberto Santos and Stephen McCleod-Bryant and Clifton Tennison and Go, {Rodney C.P.}",
year = "2006",
month = "1",
day = "1",
doi = "10.1016/j.schres.2006.06.027",
language = "English (US)",
volume = "87",
pages = "32--44",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Project among African-Americans to explore risks for schizophrenia (PAARTNERS)

T2 - Recruitment and assessment methods

AU - Aliyu, Muktar H.

AU - Calkins, Monica E.

AU - Swanson, Charlie L.

AU - Lyons, Paul D.

AU - Savage, Robert M.

AU - May, Roberta

AU - Wiener, Howard

AU - Devlin, Bernie

AU - Nimgaonkar, Vishwajit L.

AU - Ragland, J. Daniel

AU - Gur, Raquel E.

AU - Gur, Ruben C.

AU - Bradford, L. Dianne

AU - Edwards, Neil

AU - Kwentus, Joseph

AU - McEvoy, Joseph Patrick

AU - Santos, Alberto

AU - McCleod-Bryant, Stephen

AU - Tennison, Clifton

AU - Go, Rodney C.P.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The Project among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) is a multi-site, NIMH-funded study that seeks to identify genetic polymorphisms that confer susceptibility to schizophrenia among African-Americans by linkage mapping and targeted association analyses. Because deficits in certain dimensions of cognitive ability are thought to underlie liability to schizophrenia, the project also examines cognitive abilities in individuals affected by schizophrenia and their extended family members. This article describes PAARTNERS study design, ascertainment methods and preliminary sample characteristics. We aim to recruit a sample of 1260 African-American families, all of whom have at least one proband with schizophrenia or schizoaffective disorder. The data collection protocol includes a structured Diagnostic Interview for Genetic Studies, Family Interview for Genetic Studies, focused neurocognitive assessment, medical records review, and the collection of blood or buccal cells for genetic analyses. We have currently completed study procedures for 106 affected sib-pair, 457 case-parent trio and 23 multiplex families. A total of 289 probands have completed the best estimate final diagnosis process and 1153 probands and family members have been administered the computerized neuropsychological battery. This project lays the foundation for future analysis of cognitive and behavioral endophenotypes. This novel integration of diagnostic, neurocognitive and genetic data will also generate valuable information for future phenotypic and genetic studies of schizophrenia.

AB - The Project among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) is a multi-site, NIMH-funded study that seeks to identify genetic polymorphisms that confer susceptibility to schizophrenia among African-Americans by linkage mapping and targeted association analyses. Because deficits in certain dimensions of cognitive ability are thought to underlie liability to schizophrenia, the project also examines cognitive abilities in individuals affected by schizophrenia and their extended family members. This article describes PAARTNERS study design, ascertainment methods and preliminary sample characteristics. We aim to recruit a sample of 1260 African-American families, all of whom have at least one proband with schizophrenia or schizoaffective disorder. The data collection protocol includes a structured Diagnostic Interview for Genetic Studies, Family Interview for Genetic Studies, focused neurocognitive assessment, medical records review, and the collection of blood or buccal cells for genetic analyses. We have currently completed study procedures for 106 affected sib-pair, 457 case-parent trio and 23 multiplex families. A total of 289 probands have completed the best estimate final diagnosis process and 1153 probands and family members have been administered the computerized neuropsychological battery. This project lays the foundation for future analysis of cognitive and behavioral endophenotypes. This novel integration of diagnostic, neurocognitive and genetic data will also generate valuable information for future phenotypic and genetic studies of schizophrenia.

KW - African-American

KW - Endophenotype

KW - Genetics

KW - Neurocognitive

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=33748905166&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748905166&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2006.06.027

DO - 10.1016/j.schres.2006.06.027

M3 - Article

C2 - 16887335

AN - SCOPUS:33748905166

VL - 87

SP - 32

EP - 44

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -