Propagation and Regulation of Systemic Autoimmunity by γδ T Cells

Stanford L. Peng, Michael P. Madaio, Adrian C. Hayday, Joe Craft

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Although many studies have demonstrated a pathogenic role for αβ T cells in murine lupus, little work has addressed γδ T cells. Here, the roles of αβ and γδ T cells in the pathogenesis of systemic autoimmunity were investigated by generating lupus-prone mice deficient in αβ T cells and/or γδ T cells. Mice deficient in γδ T cells developed an exacerbated disease phenotype compared with that of T cell-intact mice, consisting of augmented hypergammaglobulinemia and autoantibody production, more severe renal disease, and increased mortality, associated with a polyclonal expansion of conventional CD4+ αβ T cells. Conversely, αβ T cell-deficient animals developed a partial lupus syndrome, characterized by isotype-specific hypergammaglobulinemia, incompletely penetrant autoantibodies, and mild immune complex renal disease, all of which were driven by γδ T cell-dependent help. These data indicate that γδ T cells participate in both the regulation and the propagation of murine lupus.

Original languageEnglish (US)
Pages (from-to)5689-5698
Number of pages10
JournalJournal of Immunology
Volume157
Issue number12
StatePublished - Dec 15 1996
Externally publishedYes

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Autoimmunity
T-Lymphocytes
Hypergammaglobulinemia
Autoantibodies
Immune Complex Diseases
Kidney
Phenotype
Mortality

ASJC Scopus subject areas

  • Immunology

Cite this

Peng, S. L., Madaio, M. P., Hayday, A. C., & Craft, J. (1996). Propagation and Regulation of Systemic Autoimmunity by γδ T Cells. Journal of Immunology, 157(12), 5689-5698.

Propagation and Regulation of Systemic Autoimmunity by γδ T Cells. / Peng, Stanford L.; Madaio, Michael P.; Hayday, Adrian C.; Craft, Joe.

In: Journal of Immunology, Vol. 157, No. 12, 15.12.1996, p. 5689-5698.

Research output: Contribution to journalArticle

Peng, SL, Madaio, MP, Hayday, AC & Craft, J 1996, 'Propagation and Regulation of Systemic Autoimmunity by γδ T Cells', Journal of Immunology, vol. 157, no. 12, pp. 5689-5698.
Peng SL, Madaio MP, Hayday AC, Craft J. Propagation and Regulation of Systemic Autoimmunity by γδ T Cells. Journal of Immunology. 1996 Dec 15;157(12):5689-5698.
Peng, Stanford L. ; Madaio, Michael P. ; Hayday, Adrian C. ; Craft, Joe. / Propagation and Regulation of Systemic Autoimmunity by γδ T Cells. In: Journal of Immunology. 1996 ; Vol. 157, No. 12. pp. 5689-5698.
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