Abstract
Background: Small-bore, feeding tube occlusion is reported to be as high as 23% to 35%. Pancreatic enzyme solution has been used to dissolve internal clots in feeding tubes. This study examined the prophylactic use of pancreatic enzyme solution with continuous enteral feeding in critically ill patients. Methods: This was a randomized, unblinded trial conducted in an intensive care unit at a tertiary care hospital. Feeding tubes were randomized to receive pancreatic enzyme solution every 4 hours or usual care. Pancreatic enzyme solution contained lipase 8,000 units, amylase 30,000 units, protease activity 30,000 units, sodium bicarbonate 300 mg, and 5 mL warm sterile water. Results: Ninety-five feeding tubes were followed up in 101 patients. Ten feeding tubes (9.9%) developed primary occlusions. Analysis revealed 2/52 (4%) of the tubes in the enzyme arm had occlusions, whereas 8/49 (16%) of control tubes had occlusions (p = .04). Time to occlusion was significantly longer in the pancreatic enzyme arm (p = .02). Conclusions: The use of prophylactic pancreatic enzymes may reduce the incidence of feeding tube occlusions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 398-401 |
| Number of pages | 4 |
| Journal | Nutrition in Clinical Practice |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2003 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
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Prophylactic Pancreatic Enzymes to Reduce Feeding Tube Occlusions. / Bourgault, Annette M.; Heyland, Daren K.; Drover, John W.; Keefe, Laurie; Newman, Paula; Day, Andrew G.
In: Nutrition in Clinical Practice, Vol. 18, No. 5, 01.01.2003, p. 398-401.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prophylactic Pancreatic Enzymes to Reduce Feeding Tube Occlusions
AU - Bourgault, Annette M.
AU - Heyland, Daren K.
AU - Drover, John W.
AU - Keefe, Laurie
AU - Newman, Paula
AU - Day, Andrew G.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Background: Small-bore, feeding tube occlusion is reported to be as high as 23% to 35%. Pancreatic enzyme solution has been used to dissolve internal clots in feeding tubes. This study examined the prophylactic use of pancreatic enzyme solution with continuous enteral feeding in critically ill patients. Methods: This was a randomized, unblinded trial conducted in an intensive care unit at a tertiary care hospital. Feeding tubes were randomized to receive pancreatic enzyme solution every 4 hours or usual care. Pancreatic enzyme solution contained lipase 8,000 units, amylase 30,000 units, protease activity 30,000 units, sodium bicarbonate 300 mg, and 5 mL warm sterile water. Results: Ninety-five feeding tubes were followed up in 101 patients. Ten feeding tubes (9.9%) developed primary occlusions. Analysis revealed 2/52 (4%) of the tubes in the enzyme arm had occlusions, whereas 8/49 (16%) of control tubes had occlusions (p = .04). Time to occlusion was significantly longer in the pancreatic enzyme arm (p = .02). Conclusions: The use of prophylactic pancreatic enzymes may reduce the incidence of feeding tube occlusions.
AB - Background: Small-bore, feeding tube occlusion is reported to be as high as 23% to 35%. Pancreatic enzyme solution has been used to dissolve internal clots in feeding tubes. This study examined the prophylactic use of pancreatic enzyme solution with continuous enteral feeding in critically ill patients. Methods: This was a randomized, unblinded trial conducted in an intensive care unit at a tertiary care hospital. Feeding tubes were randomized to receive pancreatic enzyme solution every 4 hours or usual care. Pancreatic enzyme solution contained lipase 8,000 units, amylase 30,000 units, protease activity 30,000 units, sodium bicarbonate 300 mg, and 5 mL warm sterile water. Results: Ninety-five feeding tubes were followed up in 101 patients. Ten feeding tubes (9.9%) developed primary occlusions. Analysis revealed 2/52 (4%) of the tubes in the enzyme arm had occlusions, whereas 8/49 (16%) of control tubes had occlusions (p = .04). Time to occlusion was significantly longer in the pancreatic enzyme arm (p = .02). Conclusions: The use of prophylactic pancreatic enzymes may reduce the incidence of feeding tube occlusions.
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U2 - 10.1177/0115426503018005398
DO - 10.1177/0115426503018005398
M3 - Article
VL - 18
SP - 398
EP - 401
JO - Nutrition in Clinical Practice
JF - Nutrition in Clinical Practice
SN - 0884-5336
IS - 5
ER -