Prophylactic Pancreatic Enzymes to Reduce Feeding Tube Occlusions

Annette M. Bourgault, Daren K. Heyland, John W. Drover, Laurie Keefe, Paula Newman, Andrew G. Day

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Small-bore, feeding tube occlusion is reported to be as high as 23% to 35%. Pancreatic enzyme solution has been used to dissolve internal clots in feeding tubes. This study examined the prophylactic use of pancreatic enzyme solution with continuous enteral feeding in critically ill patients. Methods: This was a randomized, unblinded trial conducted in an intensive care unit at a tertiary care hospital. Feeding tubes were randomized to receive pancreatic enzyme solution every 4 hours or usual care. Pancreatic enzyme solution contained lipase 8,000 units, amylase 30,000 units, protease activity 30,000 units, sodium bicarbonate 300 mg, and 5 mL warm sterile water. Results: Ninety-five feeding tubes were followed up in 101 patients. Ten feeding tubes (9.9%) developed primary occlusions. Analysis revealed 2/52 (4%) of the tubes in the enzyme arm had occlusions, whereas 8/49 (16%) of control tubes had occlusions (p = .04). Time to occlusion was significantly longer in the pancreatic enzyme arm (p = .02). Conclusions: The use of prophylactic pancreatic enzymes may reduce the incidence of feeding tube occlusions.

Original languageEnglish (US)
Pages (from-to)398-401
Number of pages4
JournalNutrition in Clinical Practice
Volume18
Issue number5
DOIs
StatePublished - Jan 1 2003

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Enteral Nutrition
Enzymes
Sodium Bicarbonate
Tertiary Healthcare
Amylases
Lipase
Tertiary Care Centers
Critical Illness
Intensive Care Units
Peptide Hydrolases
Water
Incidence

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Bourgault, A. M., Heyland, D. K., Drover, J. W., Keefe, L., Newman, P., & Day, A. G. (2003). Prophylactic Pancreatic Enzymes to Reduce Feeding Tube Occlusions. Nutrition in Clinical Practice, 18(5), 398-401. https://doi.org/10.1177/0115426503018005398

Prophylactic Pancreatic Enzymes to Reduce Feeding Tube Occlusions. / Bourgault, Annette M.; Heyland, Daren K.; Drover, John W.; Keefe, Laurie; Newman, Paula; Day, Andrew G.

In: Nutrition in Clinical Practice, Vol. 18, No. 5, 01.01.2003, p. 398-401.

Research output: Contribution to journalArticle

Bourgault, AM, Heyland, DK, Drover, JW, Keefe, L, Newman, P & Day, AG 2003, 'Prophylactic Pancreatic Enzymes to Reduce Feeding Tube Occlusions', Nutrition in Clinical Practice, vol. 18, no. 5, pp. 398-401. https://doi.org/10.1177/0115426503018005398
Bourgault AM, Heyland DK, Drover JW, Keefe L, Newman P, Day AG. Prophylactic Pancreatic Enzymes to Reduce Feeding Tube Occlusions. Nutrition in Clinical Practice. 2003 Jan 1;18(5):398-401. https://doi.org/10.1177/0115426503018005398
Bourgault, Annette M. ; Heyland, Daren K. ; Drover, John W. ; Keefe, Laurie ; Newman, Paula ; Day, Andrew G. / Prophylactic Pancreatic Enzymes to Reduce Feeding Tube Occlusions. In: Nutrition in Clinical Practice. 2003 ; Vol. 18, No. 5. pp. 398-401.
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