Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness the coronary artery risk development in young adults women's study

Ronit Calderon-Margalit, David Siscovick, Sharon S. Merkin, Erica Wang, Martha L. Daviglus, Pamela J. Schreiner, Barbara Sternfeld, O. Dale Williams, Cora E. Lewis, Ricardo Azziz, Stephen M. Schwartz, Melissa F. Wellons

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective-To study the independent associations of polycystic ovary syndrome (PCOS), and its 2 components, hyperandrogenism and anovulation, with coronary artery calcification (CAC) and carotid artery intima-media thickness (IMT).

Approach and Results-At the year 20 of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based multicenter cohort of young adults, women (mean age, 45 years) with information on menses and hirsutism in their twenties were assessed for CAC (n=982) and IMT (n=988). We defined PCOS as women who had both irregular menses and hyperandrogenism (n=55); isolated oligomenorrhea (n=103) as women who only had irregular menses; and isolated hyperandrogenism (n=156) as women who had either hirsutism or increased testosterone levels. Logistic regressions and general linear models were used to estimate the associations between components of PCOS and subclinical CVD. The prevalence of CAC was 10.3% overall. Women with PCOS had a multivariable adjusted odds ratio of 2.70 (95% confidence interval, 1.31-5.60) for CAC. Women with either isolated oligomenorrhea or isolated hyperandrogenism had no increased risk of CAC when compared with unexposed women. Women with PCOS had significantly increased bulb and internal carotid-IMT measurements; however, no significant differences were noted in bulb or internal carotid artery IMT among women with either isolated oligomenorrhea or isolated hyperandrogenism when compared with unexposed women. There were no differences in common carotid-IMT among the 4 study groups.

Conclusions-In this study, women with PCOS, manifested as both anovulation and hyperandrogenism, but not women with one of these manifestations alone, were at increased risk for the development of subclinical CVD.

Original languageEnglish (US)
Pages (from-to)2688-2694
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Volume34
Issue number12
DOIs
StatePublished - Dec 11 2014

Fingerprint

Carotid Intima-Media Thickness
Polycystic Ovary Syndrome
Young Adult
Coronary Vessels
Hyperandrogenism
Oligomenorrhea
Menstruation
Anovulation
Hirsutism
Internal Carotid Artery
Carotid Arteries
Testosterone
Linear Models
Logistic Models
Odds Ratio

Keywords

  • Carotid intima media thickness
  • Cohort studies
  • Coronary atherosclerosis
  • Electron beam computed tomography
  • Polycystic Ovary Syndrome
  • Risk

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness the coronary artery risk development in young adults women's study. / Calderon-Margalit, Ronit; Siscovick, David; Merkin, Sharon S.; Wang, Erica; Daviglus, Martha L.; Schreiner, Pamela J.; Sternfeld, Barbara; Dale Williams, O.; Lewis, Cora E.; Azziz, Ricardo; Schwartz, Stephen M.; Wellons, Melissa F.

In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 34, No. 12, 11.12.2014, p. 2688-2694.

Research output: Contribution to journalArticle

Calderon-Margalit, R, Siscovick, D, Merkin, SS, Wang, E, Daviglus, ML, Schreiner, PJ, Sternfeld, B, Dale Williams, O, Lewis, CE, Azziz, R, Schwartz, SM & Wellons, MF 2014, 'Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness the coronary artery risk development in young adults women's study', Arteriosclerosis, thrombosis, and vascular biology, vol. 34, no. 12, pp. 2688-2694. https://doi.org/10.1161/ATVBAHA.114.304136
Calderon-Margalit, Ronit ; Siscovick, David ; Merkin, Sharon S. ; Wang, Erica ; Daviglus, Martha L. ; Schreiner, Pamela J. ; Sternfeld, Barbara ; Dale Williams, O. ; Lewis, Cora E. ; Azziz, Ricardo ; Schwartz, Stephen M. ; Wellons, Melissa F. / Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness the coronary artery risk development in young adults women's study. In: Arteriosclerosis, thrombosis, and vascular biology. 2014 ; Vol. 34, No. 12. pp. 2688-2694.
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abstract = "Objective-To study the independent associations of polycystic ovary syndrome (PCOS), and its 2 components, hyperandrogenism and anovulation, with coronary artery calcification (CAC) and carotid artery intima-media thickness (IMT).Approach and Results-At the year 20 of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based multicenter cohort of young adults, women (mean age, 45 years) with information on menses and hirsutism in their twenties were assessed for CAC (n=982) and IMT (n=988). We defined PCOS as women who had both irregular menses and hyperandrogenism (n=55); isolated oligomenorrhea (n=103) as women who only had irregular menses; and isolated hyperandrogenism (n=156) as women who had either hirsutism or increased testosterone levels. Logistic regressions and general linear models were used to estimate the associations between components of PCOS and subclinical CVD. The prevalence of CAC was 10.3{\%} overall. Women with PCOS had a multivariable adjusted odds ratio of 2.70 (95{\%} confidence interval, 1.31-5.60) for CAC. Women with either isolated oligomenorrhea or isolated hyperandrogenism had no increased risk of CAC when compared with unexposed women. Women with PCOS had significantly increased bulb and internal carotid-IMT measurements; however, no significant differences were noted in bulb or internal carotid artery IMT among women with either isolated oligomenorrhea or isolated hyperandrogenism when compared with unexposed women. There were no differences in common carotid-IMT among the 4 study groups.Conclusions-In this study, women with PCOS, manifested as both anovulation and hyperandrogenism, but not women with one of these manifestations alone, were at increased risk for the development of subclinical CVD.",
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AU - Calderon-Margalit, Ronit

AU - Siscovick, David

AU - Merkin, Sharon S.

AU - Wang, Erica

AU - Daviglus, Martha L.

AU - Schreiner, Pamela J.

AU - Sternfeld, Barbara

AU - Dale Williams, O.

AU - Lewis, Cora E.

AU - Azziz, Ricardo

AU - Schwartz, Stephen M.

AU - Wellons, Melissa F.

PY - 2014/12/11

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N2 - Objective-To study the independent associations of polycystic ovary syndrome (PCOS), and its 2 components, hyperandrogenism and anovulation, with coronary artery calcification (CAC) and carotid artery intima-media thickness (IMT).Approach and Results-At the year 20 of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based multicenter cohort of young adults, women (mean age, 45 years) with information on menses and hirsutism in their twenties were assessed for CAC (n=982) and IMT (n=988). We defined PCOS as women who had both irregular menses and hyperandrogenism (n=55); isolated oligomenorrhea (n=103) as women who only had irregular menses; and isolated hyperandrogenism (n=156) as women who had either hirsutism or increased testosterone levels. Logistic regressions and general linear models were used to estimate the associations between components of PCOS and subclinical CVD. The prevalence of CAC was 10.3% overall. Women with PCOS had a multivariable adjusted odds ratio of 2.70 (95% confidence interval, 1.31-5.60) for CAC. Women with either isolated oligomenorrhea or isolated hyperandrogenism had no increased risk of CAC when compared with unexposed women. Women with PCOS had significantly increased bulb and internal carotid-IMT measurements; however, no significant differences were noted in bulb or internal carotid artery IMT among women with either isolated oligomenorrhea or isolated hyperandrogenism when compared with unexposed women. There were no differences in common carotid-IMT among the 4 study groups.Conclusions-In this study, women with PCOS, manifested as both anovulation and hyperandrogenism, but not women with one of these manifestations alone, were at increased risk for the development of subclinical CVD.

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KW - Carotid intima media thickness

KW - Cohort studies

KW - Coronary atherosclerosis

KW - Electron beam computed tomography

KW - Polycystic Ovary Syndrome

KW - Risk

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