Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure

Kirkwood F. Adams, Mandeep R. Mehra, Ron M. Oren, Christopher M. O'Connor, Jun R. Chiong, Jalal K. Ghali, Daniel J. Lenihan, Stephanie Dunlap, J. Herbert Patterson, Todd A. Schwartz, G. Michael Felker

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure. Methods: Data were analyzed from 254 patients in the UNITE-HF Biomarker Registry, a prospective, observational, multicenter study of the clinical and biomarker correlates of anemia in heart failure. Logistic regression modeling assessed relationships between detectable troponin T and indices of hematologic function including anemia and red cell distribution width. Results: Anemia (hemoglobin ≤12 g/dL) was present in 65 of the 254 study patients, and detectable troponin T was found in 39. Anemia was a significant independent predictor of detectable troponin T in models that considered a number of clinical characteristics including renal function, functional class, heart rate, and systolic blood pressure (odds ratio 2.57, 95% CI 1.09-6.09, P = .032). Likewise, detectable troponin T was directly and independently related to red cell distribution width in similar multivariable analyses (odds ratio 1.36 per unit increase, 95% CI 1.08-1.71, P = .008). Conclusions: Anemia and increasing red cell distribution width were independently associated with elevated troponin T, a marker of cardiomyocyte injury or death in patients with heart failure.

Original languageEnglish (US)
Pages (from-to)1142-1148
Number of pages7
JournalAmerican Heart Journal
Volume160
Issue number6
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

Troponin T
Erythropoiesis
Heart Failure
Anemia
Erythrocyte Indices
Cardiac Myocytes
Biomarkers
Odds Ratio
Blood Pressure
Multicenter Studies
Observational Studies
Registries
Hemoglobins
Heart Rate
Logistic Models
Kidney
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Adams, K. F., Mehra, M. R., Oren, R. M., O'Connor, C. M., Chiong, J. R., Ghali, J. K., ... Felker, G. M. (2010). Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure. American Heart Journal, 160(6), 1142-1148. https://doi.org/10.1016/j.ahj.2010.07.033

Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure. / Adams, Kirkwood F.; Mehra, Mandeep R.; Oren, Ron M.; O'Connor, Christopher M.; Chiong, Jun R.; Ghali, Jalal K.; Lenihan, Daniel J.; Dunlap, Stephanie; Patterson, J. Herbert; Schwartz, Todd A.; Felker, G. Michael.

In: American Heart Journal, Vol. 160, No. 6, 01.12.2010, p. 1142-1148.

Research output: Contribution to journalArticle

Adams, KF, Mehra, MR, Oren, RM, O'Connor, CM, Chiong, JR, Ghali, JK, Lenihan, DJ, Dunlap, S, Patterson, JH, Schwartz, TA & Felker, GM 2010, 'Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure', American Heart Journal, vol. 160, no. 6, pp. 1142-1148. https://doi.org/10.1016/j.ahj.2010.07.033
Adams, Kirkwood F. ; Mehra, Mandeep R. ; Oren, Ron M. ; O'Connor, Christopher M. ; Chiong, Jun R. ; Ghali, Jalal K. ; Lenihan, Daniel J. ; Dunlap, Stephanie ; Patterson, J. Herbert ; Schwartz, Todd A. ; Felker, G. Michael. / Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure. In: American Heart Journal. 2010 ; Vol. 160, No. 6. pp. 1142-1148.
@article{32599c27526e441386f42f59f81a1266,
title = "Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure",
abstract = "Background: Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure. Methods: Data were analyzed from 254 patients in the UNITE-HF Biomarker Registry, a prospective, observational, multicenter study of the clinical and biomarker correlates of anemia in heart failure. Logistic regression modeling assessed relationships between detectable troponin T and indices of hematologic function including anemia and red cell distribution width. Results: Anemia (hemoglobin ≤12 g/dL) was present in 65 of the 254 study patients, and detectable troponin T was found in 39. Anemia was a significant independent predictor of detectable troponin T in models that considered a number of clinical characteristics including renal function, functional class, heart rate, and systolic blood pressure (odds ratio 2.57, 95{\%} CI 1.09-6.09, P = .032). Likewise, detectable troponin T was directly and independently related to red cell distribution width in similar multivariable analyses (odds ratio 1.36 per unit increase, 95{\%} CI 1.08-1.71, P = .008). Conclusions: Anemia and increasing red cell distribution width were independently associated with elevated troponin T, a marker of cardiomyocyte injury or death in patients with heart failure.",
author = "Adams, {Kirkwood F.} and Mehra, {Mandeep R.} and Oren, {Ron M.} and O'Connor, {Christopher M.} and Chiong, {Jun R.} and Ghali, {Jalal K.} and Lenihan, {Daniel J.} and Stephanie Dunlap and Patterson, {J. Herbert} and Schwartz, {Todd A.} and Felker, {G. Michael}",
year = "2010",
month = "12",
day = "1",
doi = "10.1016/j.ahj.2010.07.033",
language = "English (US)",
volume = "160",
pages = "1142--1148",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure

AU - Adams, Kirkwood F.

AU - Mehra, Mandeep R.

AU - Oren, Ron M.

AU - O'Connor, Christopher M.

AU - Chiong, Jun R.

AU - Ghali, Jalal K.

AU - Lenihan, Daniel J.

AU - Dunlap, Stephanie

AU - Patterson, J. Herbert

AU - Schwartz, Todd A.

AU - Felker, G. Michael

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background: Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure. Methods: Data were analyzed from 254 patients in the UNITE-HF Biomarker Registry, a prospective, observational, multicenter study of the clinical and biomarker correlates of anemia in heart failure. Logistic regression modeling assessed relationships between detectable troponin T and indices of hematologic function including anemia and red cell distribution width. Results: Anemia (hemoglobin ≤12 g/dL) was present in 65 of the 254 study patients, and detectable troponin T was found in 39. Anemia was a significant independent predictor of detectable troponin T in models that considered a number of clinical characteristics including renal function, functional class, heart rate, and systolic blood pressure (odds ratio 2.57, 95% CI 1.09-6.09, P = .032). Likewise, detectable troponin T was directly and independently related to red cell distribution width in similar multivariable analyses (odds ratio 1.36 per unit increase, 95% CI 1.08-1.71, P = .008). Conclusions: Anemia and increasing red cell distribution width were independently associated with elevated troponin T, a marker of cardiomyocyte injury or death in patients with heart failure.

AB - Background: Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure. Methods: Data were analyzed from 254 patients in the UNITE-HF Biomarker Registry, a prospective, observational, multicenter study of the clinical and biomarker correlates of anemia in heart failure. Logistic regression modeling assessed relationships between detectable troponin T and indices of hematologic function including anemia and red cell distribution width. Results: Anemia (hemoglobin ≤12 g/dL) was present in 65 of the 254 study patients, and detectable troponin T was found in 39. Anemia was a significant independent predictor of detectable troponin T in models that considered a number of clinical characteristics including renal function, functional class, heart rate, and systolic blood pressure (odds ratio 2.57, 95% CI 1.09-6.09, P = .032). Likewise, detectable troponin T was directly and independently related to red cell distribution width in similar multivariable analyses (odds ratio 1.36 per unit increase, 95% CI 1.08-1.71, P = .008). Conclusions: Anemia and increasing red cell distribution width were independently associated with elevated troponin T, a marker of cardiomyocyte injury or death in patients with heart failure.

UR - http://www.scopus.com/inward/record.url?scp=78650112979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650112979&partnerID=8YFLogxK

U2 - 10.1016/j.ahj.2010.07.033

DO - 10.1016/j.ahj.2010.07.033

M3 - Article

C2 - 21146670

AN - SCOPUS:78650112979

VL - 160

SP - 1142

EP - 1148

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 6

ER -