TY - JOUR
T1 - Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure
AU - Adams, Kirkwood F.
AU - Mehra, Mandeep R.
AU - Oren, Ron M.
AU - O'Connor, Christopher M.
AU - Chiong, Jun R.
AU - Ghali, Jalal K.
AU - Lenihan, Daniel J.
AU - Dunlap, Stephanie
AU - Patterson, J. Herbert
AU - Schwartz, Todd A.
AU - Felker, G. Michael
N1 - Funding Information:
The registry was funded by an investigator-initiated grant from Amgen Inc (Thousand Oaks, CA). The sponsor participated in discussions concerning original study design; but the sponsor had no role in any aspect of the conduct of the study, including data collection and study management. The sponsor also had no role in the data analysis and preparation of the current manuscript. All authors had full access to the study data that were stored at the UNITE-HF Coordinating Center at the University of North Carolina at Chapel Hill. As the lead author, Dr. Adams takes responsibility for the content of the manuscript.
PY - 2010/12
Y1 - 2010/12
N2 - Background: Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure. Methods: Data were analyzed from 254 patients in the UNITE-HF Biomarker Registry, a prospective, observational, multicenter study of the clinical and biomarker correlates of anemia in heart failure. Logistic regression modeling assessed relationships between detectable troponin T and indices of hematologic function including anemia and red cell distribution width. Results: Anemia (hemoglobin ≤12 g/dL) was present in 65 of the 254 study patients, and detectable troponin T was found in 39. Anemia was a significant independent predictor of detectable troponin T in models that considered a number of clinical characteristics including renal function, functional class, heart rate, and systolic blood pressure (odds ratio 2.57, 95% CI 1.09-6.09, P = .032). Likewise, detectable troponin T was directly and independently related to red cell distribution width in similar multivariable analyses (odds ratio 1.36 per unit increase, 95% CI 1.08-1.71, P = .008). Conclusions: Anemia and increasing red cell distribution width were independently associated with elevated troponin T, a marker of cardiomyocyte injury or death in patients with heart failure.
AB - Background: Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure. Methods: Data were analyzed from 254 patients in the UNITE-HF Biomarker Registry, a prospective, observational, multicenter study of the clinical and biomarker correlates of anemia in heart failure. Logistic regression modeling assessed relationships between detectable troponin T and indices of hematologic function including anemia and red cell distribution width. Results: Anemia (hemoglobin ≤12 g/dL) was present in 65 of the 254 study patients, and detectable troponin T was found in 39. Anemia was a significant independent predictor of detectable troponin T in models that considered a number of clinical characteristics including renal function, functional class, heart rate, and systolic blood pressure (odds ratio 2.57, 95% CI 1.09-6.09, P = .032). Likewise, detectable troponin T was directly and independently related to red cell distribution width in similar multivariable analyses (odds ratio 1.36 per unit increase, 95% CI 1.08-1.71, P = .008). Conclusions: Anemia and increasing red cell distribution width were independently associated with elevated troponin T, a marker of cardiomyocyte injury or death in patients with heart failure.
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U2 - 10.1016/j.ahj.2010.07.033
DO - 10.1016/j.ahj.2010.07.033
M3 - Article
C2 - 21146670
AN - SCOPUS:78650112979
SN - 0002-8703
VL - 160
SP - 1142
EP - 1148
JO - American Heart Journal
JF - American Heart Journal
IS - 6
ER -