Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure

Kirkwood F. Adams, Mandeep R. Mehra, Ron M. Oren, Christopher M. O'Connor, Jun R. Chiong, Jalal K. Ghali, Daniel J. Lenihan, Stephanie Dunlap, J. Herbert Patterson, Todd A. Schwartz, G. Michael Felker

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background: Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure. Methods: Data were analyzed from 254 patients in the UNITE-HF Biomarker Registry, a prospective, observational, multicenter study of the clinical and biomarker correlates of anemia in heart failure. Logistic regression modeling assessed relationships between detectable troponin T and indices of hematologic function including anemia and red cell distribution width. Results: Anemia (hemoglobin ≤12 g/dL) was present in 65 of the 254 study patients, and detectable troponin T was found in 39. Anemia was a significant independent predictor of detectable troponin T in models that considered a number of clinical characteristics including renal function, functional class, heart rate, and systolic blood pressure (odds ratio 2.57, 95% CI 1.09-6.09, P = .032). Likewise, detectable troponin T was directly and independently related to red cell distribution width in similar multivariable analyses (odds ratio 1.36 per unit increase, 95% CI 1.08-1.71, P = .008). Conclusions: Anemia and increasing red cell distribution width were independently associated with elevated troponin T, a marker of cardiomyocyte injury or death in patients with heart failure.

Original languageEnglish (US)
Pages (from-to)1142-1148
Number of pages7
JournalAmerican Heart Journal
Volume160
Issue number6
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure'. Together they form a unique fingerprint.

Cite this