TY - JOUR
T1 - Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure
AU - Adams, Kirkwood F.
AU - Piña, Ileana L.
AU - Ghali, Jalal K.
AU - Wagoner, Lynne E.
AU - Dunlap, Stephanie
AU - Schwartz, Todd A.
AU - Stough, Wendy Gattis
AU - Mehra, Mandeep R.
AU - Felker, Gary Michael
AU - Chiong, Jun R.
AU - Patterson, James Herbert
AU - Kim, John
AU - Butler, Javed
AU - Oren, Ron M.
N1 - Funding Information:
This study was solely funded by Amgen, Inc (Thousand Oaks, CA) through a research grant to the University of North Carolina at Chapel Hill (Chapel Hill, NC). The authors had full and independent access to the study data as it was stored at the UNITE-HF Coordinating Center at the University of North Carolina at Chapel Hill. All analyses presented in this article were performed by the authors. As agreed in the study publication contract, the sponsors had the right to review the final manuscript and offer comments, which they exercised, but control of the final content of the manuscript was the sole responsibility of the authors.
PY - 2009/12
Y1 - 2009/12
N2 - Background: Reduced hemoglobin has been associated with adverse outcomes in heart failure, but the relationship of hemoglobin to health-related quality of life in outpatients with this syndrome has not been well studied. Methods: We used data from the prospective, observational Study of Anemia in a Heart Failure Population Registry, which randomly selected outpatients with heart failure from specialty or community cardiology clinics. Hemoglobin was determined by finger stick at baseline and during medically indicated follow-up visits. Health-related quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire and the Minnesota Living with Heart Failure Questionnaire at 3-month intervals for 12 months. Results: Adjusted regression analysis demonstrated a significant, direct, linear relationship between hemoglobin and health-related quality of life from baseline through 12 months follow-up on all Kansas City Cardiomyopathy Questionnaire domains (all P < .001) and the Summary and Physical domains of the Minnesota Living with Heart Failure Questionnaire (all P < .05). Adjusted categorical analysis of the change in Kansas City Cardiomyopathy Questionnaire Clinical scores associated with change in hemoglobin from baseline to 6 months also showed a significant relationship between increasing hemoglobin and improved health status (5.9 ± 1.8 units for a hemoglobin increase of ≥1 g/dL, 0.7 ± 1.2 units for change in hemoglobin <1 g/dL, and -2.6 ± 1.4 units for a ≥1 g/dL decrease in hemoglobin, P < .001). Conclusions: These prospective, observational results indicate that reduced hemoglobin is associated with poorer quality of life in patients with heart failure. Additional studies will be required to establish if this is a cause-and-effect relationship.
AB - Background: Reduced hemoglobin has been associated with adverse outcomes in heart failure, but the relationship of hemoglobin to health-related quality of life in outpatients with this syndrome has not been well studied. Methods: We used data from the prospective, observational Study of Anemia in a Heart Failure Population Registry, which randomly selected outpatients with heart failure from specialty or community cardiology clinics. Hemoglobin was determined by finger stick at baseline and during medically indicated follow-up visits. Health-related quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire and the Minnesota Living with Heart Failure Questionnaire at 3-month intervals for 12 months. Results: Adjusted regression analysis demonstrated a significant, direct, linear relationship between hemoglobin and health-related quality of life from baseline through 12 months follow-up on all Kansas City Cardiomyopathy Questionnaire domains (all P < .001) and the Summary and Physical domains of the Minnesota Living with Heart Failure Questionnaire (all P < .05). Adjusted categorical analysis of the change in Kansas City Cardiomyopathy Questionnaire Clinical scores associated with change in hemoglobin from baseline to 6 months also showed a significant relationship between increasing hemoglobin and improved health status (5.9 ± 1.8 units for a hemoglobin increase of ≥1 g/dL, 0.7 ± 1.2 units for change in hemoglobin <1 g/dL, and -2.6 ± 1.4 units for a ≥1 g/dL decrease in hemoglobin, P < .001). Conclusions: These prospective, observational results indicate that reduced hemoglobin is associated with poorer quality of life in patients with heart failure. Additional studies will be required to establish if this is a cause-and-effect relationship.
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U2 - 10.1016/j.ahj.2009.10.015
DO - 10.1016/j.ahj.2009.10.015
M3 - Article
C2 - 19958863
AN - SCOPUS:70549096093
VL - 158
SP - 965
EP - 971
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 6
ER -