Abstract
Background: Reduced hemoglobin has been associated with adverse outcomes in heart failure, but the relationship of hemoglobin to health-related quality of life in outpatients with this syndrome has not been well studied. Methods: We used data from the prospective, observational Study of Anemia in a Heart Failure Population Registry, which randomly selected outpatients with heart failure from specialty or community cardiology clinics. Hemoglobin was determined by finger stick at baseline and during medically indicated follow-up visits. Health-related quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire and the Minnesota Living with Heart Failure Questionnaire at 3-month intervals for 12 months. Results: Adjusted regression analysis demonstrated a significant, direct, linear relationship between hemoglobin and health-related quality of life from baseline through 12 months follow-up on all Kansas City Cardiomyopathy Questionnaire domains (all P < .001) and the Summary and Physical domains of the Minnesota Living with Heart Failure Questionnaire (all P < .05). Adjusted categorical analysis of the change in Kansas City Cardiomyopathy Questionnaire Clinical scores associated with change in hemoglobin from baseline to 6 months also showed a significant relationship between increasing hemoglobin and improved health status (5.9 ± 1.8 units for a hemoglobin increase of ≥1 g/dL, 0.7 ± 1.2 units for change in hemoglobin <1 g/dL, and -2.6 ± 1.4 units for a ≥1 g/dL decrease in hemoglobin, P < .001). Conclusions: These prospective, observational results indicate that reduced hemoglobin is associated with poorer quality of life in patients with heart failure. Additional studies will be required to establish if this is a cause-and-effect relationship.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 965-971 |
| Number of pages | 7 |
| Journal | American Heart Journal |
| Volume | 158 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure. / Adams, Kirkwood F.; Piña, Ileana L.; Ghali, Jalal K.; Wagoner, Lynne E.; Dunlap, Stephanie; Schwartz, Todd A.; Stough, Wendy Gattis; Mehra, Mandeep R.; Felker, Gary Michael; Chiong, Jun R.; Patterson, James Herbert; Kim, John; Butler, Javed; Oren, Ron M.
In: American Heart Journal, Vol. 158, No. 6, 01.12.2009, p. 965-971.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure
AU - Adams, Kirkwood F.
AU - Piña, Ileana L.
AU - Ghali, Jalal K.
AU - Wagoner, Lynne E.
AU - Dunlap, Stephanie
AU - Schwartz, Todd A.
AU - Stough, Wendy Gattis
AU - Mehra, Mandeep R.
AU - Felker, Gary Michael
AU - Chiong, Jun R.
AU - Patterson, James Herbert
AU - Kim, John
AU - Butler, Javed
AU - Oren, Ron M.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Background: Reduced hemoglobin has been associated with adverse outcomes in heart failure, but the relationship of hemoglobin to health-related quality of life in outpatients with this syndrome has not been well studied. Methods: We used data from the prospective, observational Study of Anemia in a Heart Failure Population Registry, which randomly selected outpatients with heart failure from specialty or community cardiology clinics. Hemoglobin was determined by finger stick at baseline and during medically indicated follow-up visits. Health-related quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire and the Minnesota Living with Heart Failure Questionnaire at 3-month intervals for 12 months. Results: Adjusted regression analysis demonstrated a significant, direct, linear relationship between hemoglobin and health-related quality of life from baseline through 12 months follow-up on all Kansas City Cardiomyopathy Questionnaire domains (all P < .001) and the Summary and Physical domains of the Minnesota Living with Heart Failure Questionnaire (all P < .05). Adjusted categorical analysis of the change in Kansas City Cardiomyopathy Questionnaire Clinical scores associated with change in hemoglobin from baseline to 6 months also showed a significant relationship between increasing hemoglobin and improved health status (5.9 ± 1.8 units for a hemoglobin increase of ≥1 g/dL, 0.7 ± 1.2 units for change in hemoglobin <1 g/dL, and -2.6 ± 1.4 units for a ≥1 g/dL decrease in hemoglobin, P < .001). Conclusions: These prospective, observational results indicate that reduced hemoglobin is associated with poorer quality of life in patients with heart failure. Additional studies will be required to establish if this is a cause-and-effect relationship.
AB - Background: Reduced hemoglobin has been associated with adverse outcomes in heart failure, but the relationship of hemoglobin to health-related quality of life in outpatients with this syndrome has not been well studied. Methods: We used data from the prospective, observational Study of Anemia in a Heart Failure Population Registry, which randomly selected outpatients with heart failure from specialty or community cardiology clinics. Hemoglobin was determined by finger stick at baseline and during medically indicated follow-up visits. Health-related quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire and the Minnesota Living with Heart Failure Questionnaire at 3-month intervals for 12 months. Results: Adjusted regression analysis demonstrated a significant, direct, linear relationship between hemoglobin and health-related quality of life from baseline through 12 months follow-up on all Kansas City Cardiomyopathy Questionnaire domains (all P < .001) and the Summary and Physical domains of the Minnesota Living with Heart Failure Questionnaire (all P < .05). Adjusted categorical analysis of the change in Kansas City Cardiomyopathy Questionnaire Clinical scores associated with change in hemoglobin from baseline to 6 months also showed a significant relationship between increasing hemoglobin and improved health status (5.9 ± 1.8 units for a hemoglobin increase of ≥1 g/dL, 0.7 ± 1.2 units for change in hemoglobin <1 g/dL, and -2.6 ± 1.4 units for a ≥1 g/dL decrease in hemoglobin, P < .001). Conclusions: These prospective, observational results indicate that reduced hemoglobin is associated with poorer quality of life in patients with heart failure. Additional studies will be required to establish if this is a cause-and-effect relationship.
UR - http://www.scopus.com/inward/record.url?scp=70549096093&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70549096093&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2009.10.015
DO - 10.1016/j.ahj.2009.10.015
M3 - Article
C2 - 19958863
AN - SCOPUS:70549096093
VL - 158
SP - 965
EP - 971
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 6
ER -