Prostate cancer gene therapy and the role of radiation

Joseph Michael Kaminski, K. Nguyen, M. Buyyounouski, A. Pollack

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Even though prostate cancer is detected earlier than in the pre-PSA era, prostate cancer is the second leading cause of cancer mortality in the American male. Prostate cancer therapy is not ideal, especially for high-risk localized and metastatic cancer; therefore, investigators have sought new therapeutic modalities such as angiogenesis inhibitors, inhibitors of the cell signaling pathway, vaccines, and gene therapy. Gene therapy has emerged as potential therapy for both localized and systemic prostate cancer. Gene therapy has been shown to work supra-additively with radiation in controlling prostate cancer in vivo. With further technological advances in radiation therapy, gene therapy, and the understanding of prostate cancer biology, gene therapy will potentially have an important role in prostate cancer therapy.

Original languageEnglish (US)
Pages (from-to)49-64
Number of pages16
JournalCancer Treatment Reviews
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2002

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Neoplasm Genes
Genetic Therapy
Prostatic Neoplasms
Radiation
Active Immunotherapy
Angiogenesis Inhibitors
Therapeutics
Neoplasms
Radiotherapy
Research Personnel
Mortality

Keywords

  • Gene therapy
  • Prostate cancer
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Kaminski, J. M., Nguyen, K., Buyyounouski, M., & Pollack, A. (2002). Prostate cancer gene therapy and the role of radiation. Cancer Treatment Reviews, 28(1), 49-64. https://doi.org/10.1053/ctrv.2002.0250

Prostate cancer gene therapy and the role of radiation. / Kaminski, Joseph Michael; Nguyen, K.; Buyyounouski, M.; Pollack, A.

In: Cancer Treatment Reviews, Vol. 28, No. 1, 01.01.2002, p. 49-64.

Research output: Contribution to journalArticle

Kaminski, JM, Nguyen, K, Buyyounouski, M & Pollack, A 2002, 'Prostate cancer gene therapy and the role of radiation', Cancer Treatment Reviews, vol. 28, no. 1, pp. 49-64. https://doi.org/10.1053/ctrv.2002.0250
Kaminski JM, Nguyen K, Buyyounouski M, Pollack A. Prostate cancer gene therapy and the role of radiation. Cancer Treatment Reviews. 2002 Jan 1;28(1):49-64. https://doi.org/10.1053/ctrv.2002.0250
Kaminski, Joseph Michael ; Nguyen, K. ; Buyyounouski, M. ; Pollack, A. / Prostate cancer gene therapy and the role of radiation. In: Cancer Treatment Reviews. 2002 ; Vol. 28, No. 1. pp. 49-64.
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