Protective effect of Clerodendron glandulosum extract against experimentally induced metabolic syndrome in rats

Ravirajsinh N. Jadeja, Menaka C. Thounaojam, Ansarullah, Vaibhav B. Patel, Ranjitsinh V. Devkar, A. V. Ramachandran

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Context: Metabolic syndrome (MetS) has become one of the major health burdens worldwide. To date, no single pharmacological agent has been developed to correct metabolic abnormalities associated with MetS. Use of indigenous medicinal plants as alternative medicines against MetS could be beneficial due to multiple therapeutic usage, easy availability, and relatively few side effects. Objective: To investigate the protective effect of Clerodendron glandulosum Coleb. (Verbenaceae) aqueous leaf extract (CgE) against experimentally induced MetS in rats. Methods: Changes in body weight, food and fluid intake, plasma glucose, insulin, fasting insulin resistance index (FIRI), plasma total lipid profile, free fatty acids (FFA), oral glucose tolerance test (OGTT), blood pressure and vascular reactivity have been investigated in various experimental groups. Results: FructoseCgE groups recorded significant decrement (P <0.05) in plasma glucose, insulin, FIRI, total cholesterol, triglycerides, LDL, VLDL and FFA, whereas plasma HDL level was significantly increased (P <0.05) along with an efficient clearance of glucose during OGTT and lowered area under curve values. FRUCgE groups also showed significantly decreased (P <0.05) mean arterial blood pressure along with decreased vasoconstriction and increased vasorelaxation in response to administration of various pharmacological agents. These results were comparable with metformin treated rats. Discussion: C. glandulosum leaf extract ameliorates experimentally induced MetS by improving dyslipidemia and insulin resistance. Conclusion: This study provides the first pharmacological evidence for the protective role of C. glandulosum leaves against experimentally induced MetS. Thus, therapeutic use of C. glandulosum in controlling MetS is indicated.

Original languageEnglish (US)
Pages (from-to)1312-1319
Number of pages8
JournalPharmaceutical Biology
Volume48
Issue number12
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

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Keywords

  • Charles foster rats
  • Clerodendron glandulosum aqueous extract
  • Dyslipidemia
  • Insulin resistance
  • Metabolic syndrome

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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